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Matti Narkia

Vitamin D3-Triggered Antimicrobial Response--Another Pleiotropic Effect beyond Mineral and Bone Metabolism: Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response. - J. Am. Soc. Nephrol., November 1 - 0 views

jasn.asnjournals.org/...2949

2006 November study review vitamin D vitamin_D vitamin_D3 Antimicrobial Response Pleiotropic Effect calcitriol nutrition innate immunity innate_immunity 25ohd calcidiol 1.25(OH)2d

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  • Matti Narkia on 06 Aug 09
     
    P.T. Liu, S. Stenger, H. Li, L. Wenzel, B.H. Tan, S.R. Krutzik, M.T. Ochoa, J. Schauber, K. Wu, C. Meinken, et al.\nVitamin D3-Triggered Antimicrobial Response--Another Pleiotropic Effect beyond Mineral and Bone Metabolism: Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response. Science 311: 1770-1773, 2006\nJ. Am. Soc. Nephrol., November 1, 2006; 17(11): 2949 - 2953.
Matti Narkia

Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway. - Biol Reprod. 2009 Mar - 0 views

www.biolreprod.org/...398

2009 March study research in_vitro vitamin D vitamin_D calcitriol immunology innate immunity innate_immunity cathelicidin trophoblasts placenta intracrine nutrition medline 25ohd calcidiol intracrine_synthesis Antibacterial 1.25(OH)2d

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    'Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway.\nLiu N, Kaplan AT, Low J, Nguyen L, Liu GY, Equils O, Hewison M.\nBiol Reprod. 2009 Mar;80(3):398-406. Epub 2008 Nov 12.\nPMID: 19005165DOI: 10.1095/biolreprod.108.073577
Matti Narkia

The Heart Scan Blog: Unique vitamin D observations - 0 views

heartscanblog.blogspot.com/...ue-vitamin-d-observations.html

2009 February blog_article vitamin D vitamin_D Unique observations nutrition Ankylosing spondylitis Ankylosing_spondylitis Aortic valve disease Aortic_valve_disease Chest pain Chest_pain claustrophobia viral infections immunity

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  • Matti Narkia on 06 Aug 09
     
    It seems not a single day passes that I don't learn something new about this unique hormone (mis)named "vitamin D." \nFrom its humble beginnings recognized only as the factor responsible for bone maturation (with deficiency leading to childhood rickets), vitamin D now commands a recognized role in almost every conceivable aspect of health and disease. \n
Matti Narkia

Back to the future: a new look at 'old' vitamin D. - J Endocrinol. 2008 Aug; - 0 views

joe.endocrinology-journals.org/...261

2008 August study review vitamin D vitamin_D new look innate immunity innate_immunity adaptive calcitriol nutrition medline insufficiency Vitamin_D-binding_protein DBP cathelicidin evolution VDRE-BP physiology mechanisms 1.25(OH)2d

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    Back to the future: a new look at 'old' vitamin D. Chun RF, Adams JS, Hewison M. J Endocrinol. 2008 Aug;198(2):261-9. Epub 2008 May 21. PMID: 18495944 DOI: 10.1677/JOE-08-0170
Matti Narkia

Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. - J Immunol. 2007 Aug 15 - 0 views

www.jimmunol.org/...2060

2007 August study research in_vitro vitamin D vitamin_D vitamin_D-mediated antimicrobial activity antimicrobial_activity Mycobacterium_tuberculosis TB cathelicidin nutrition medline innate immunity innate_immunity calcitriol 1.25(OH)2d tuberculosis

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    Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.\nLiu PT, Stenger S, Tang DH, Modlin RL.\nJ Immunol. 2007 Aug 15;179(4):2060-3.\nPMID: 1767546
Matti Narkia

Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). - Age Ageing. 2007 Sep - 0 views

ageing.oxfordjournals.org/...574

2007 September study research clinical_trial rct humans older old elderly aging vitamin D vitamin_D supplementation supplements supplemental infections infection prevention nutrition medline innate immunity innate_immunity

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  • Matti Narkia on 06 Aug 09
     
    Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438).\nAvenell A, Cook JA, Maclennan GS, Macpherson GC.\nAge Ageing. 2007 Sep;36(5):574-7. Epub 2007 Aug 15. No abstract available.\nPMID: 17702768 \ndoi:10.1093/ageing/afm091
Matti Narkia

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. - FASEB J. 2005 Jul - 0 views

www.fasebj.org/...1067

2005 July FASEB study research in_vitro vitamin D vitamin_D 1.25-dihydroxyvitamin_D calcitriol nutrition antimicrobial peptides defensins cathelicidins cathelicidin medline sepsis wound_healing monocytes VDRE innate immunity innate_immunity

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  • Matti Narkia on 06 Aug 09
     
    Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.\nGombart AF, Borregaard N, Koeffler HP.\nFASEB J. 2005 Jul;19(9):1067-77.\nPMID: 15985530
Matti Narkia

The antibiotic vitamin: deficiency in vitamin D may predispose people to infection | Science News | Find Articles at BNET - 0 views

findarticles.com/...ai_n16865477

2006 November news vitamin D vitamin_D deficiency low_levels low levels infection influenza epidemic Cannell cathelicidin nutrition antimicrobial immunity immune_system supplementation calcitriol

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  • Matti Narkia on 06 Aug 09
     
    In the July 2005 FASEB Journal, Adrian F. Gombart of the University of California, Los Angeles (UCLA) and his colleagues reported that vitamin D boosts production in white blood cells of one of the antimicrobial compounds that defends the body against germs.\n\nImmediately, Cannell says, the proverbial lightbulb went on in his head: Maybe the high doses of vitamin D that he had been prescribing to virtually all the men on his ward had boosted their natural arsenal of the antimicrobial, called cathelicidin, and protected them from flu. Cannell had been administering the vitamin D because his patients, like many other people in the industrial world, had shown a deficiency:
Matti Narkia

Vitamin D deficiency linked to more colds and flu: Scientific American Blog - 0 views

www.sciam.com/...post.cfm

2009 February sciam news vitamin D vitamin_D deficiency levels low_levels 25ohd calcidiol flu common cold colds common cold upper_respiratory_tract_infection URTI nutrition sunshine immunity immune_system

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  • Matti Narkia on 06 Aug 09
     
    Is sunshine more than just a home remedy for a cold? New research suggests it may be: In a study that will be published tomorrow, people with low levels of vitamin D - also known as the "sunshine vitamin" - were more likely to catch cold and flu than folks with adequate amounts. The effect of the vitamin was strongest in people with asthma and other lung diseases who are predisposed to respiratory infections.
Matti Narkia

Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey, February 23, 2009, Ginde et al. 169 (4): 384 Arch Intern Med -- Abstract: - 0 views

archinte.ama-assn.org/...384

2009 February study research epidemiological humans vitamin D vitamin_D status level 25ohd calcidiol Upper_Respiratory_Tract_Infection URTI flu nutrition medline common cold common_cold innate immunity innate_immunity

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    Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection. \nAdit A. Ginde, MD, MPH; Jonathan M. Mansbach, MD; Carlos A. Camargo Jr, MD, DrPH . \nArch Intern Med. 2009;169(4):384-390\n
Matti Narkia

Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostomy tubes. - .[Ann Otol Rhinol Laryngol. 2008] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...18998501

2008 October study research Case_series humans children young vitamin D vitamin_D status levels 25ohd calcidiol tympanostomy tubes medline ear infection antimicrobial peptides ear_infection immunity ears Holick epidemiological nutrition

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    Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostomy tubes.\nLinday LA, Shindledecker RD, Dolitsky JN, Chen TC, Holick MF.\nAnn Otol Rhinol Laryngol. 2008 Oct;117(10):740-4.\nPMID: 18998501
Matti Narkia

Vitamin D -- Dusso et al. 289 (1): F8 -- AJP - Renal Physiology - 0 views

ajprenal.physiology.org/...F8

metabolism receptor calcium homeostasis transcriptional regulation rapid steroid actions nutrition sun sunlight sunshine medicine medline science study review peer-reviewed VDR calcitriol immunomodulation immune system imported delicio vitamin_D

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    Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28. Review. PMID: 15951480 [PubMed - indexed for MEDLINE]
Matti Narkia

Vitamin D - Linus Pauling Institute at Oregon State University - 0 views

lpi.oregonstate.edu/...vitaminD

vitamin D nutrition Linus Pauling Institute Pauling vitamin_D info reference Calcium_Balance Cell_Differentiation Immunity Insulin_Secretion Blood_Pressure bp Deficiency rickets Osteoporosis cancer Autoimmune_Diseases safety Sunlight diabetes CVD MS

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  • Matti Narkia on 06 Aug 09
     
    Vitamin D is a fat-soluble vitamin that is essential for maintaining normal calcium metabolism (1). Vitamin D3 (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight, or it can be obtained from the diet. Plants synthesize ergosterol, which is converted to vitamin D2 (ergocalciferol) by ultraviolet light. Vitamin D2 is less active in birds than vitamin D3 and may also be less active in humans (2). When exposure to UVB radiation is insufficient for the synthesis of adequate amounts of vitamin D3 in the skin, adequate intake of vitamin D from the diet is essential for health.
Matti Narkia

Evolution and function of vitamin D. [Recent Results Cancer Res. 2003] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...12899511

2003 study review humans Holick vitamin_D evolution function plankton zooplankton phytoplankton sunlight diet VDR 25ohd calcitriol immune system regulation renin-angiotensin MS diabetes nutrition medline latitude PTH hypertension CVD

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  • Matti Narkia on 05 Sep 09
     
    Evolution and function of vitamin D. Holick MF. Recent Results Cancer Res. 2003;164:3-28. Review. PMID: 12899511
Matti Narkia

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? - Nutrition & Metabolism | Full text - 0 views

www.nutritionandmetabolism.com/...16

2009 April study review humans lifestyle-induced metabolic inflexibility accelerated ageing syndrome aging insulin_resistance medline mitochondria hormesis metabolic_syndrome redox-thriftiness calorie restriction caloric CR immune system inflammation

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    Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nunn AV, Bell JD, Guy GW. Nutr Metab (Lond). 2009 Apr 16;6:16. PMID: 19371409 doi:10.1186/1743-7075-6-16
Matti Narkia

Vitamin D treatment in multiple sclerosis - ScienceDirect - Journal of the Neurological Sciences - 0 views

www.sciencedirect.com/science

2009 June study review humans multiple sclerosis multiple_sclerosis MS vitamin_D treatment prevention supplementation disease modifying nutrition medline immunomodulation immune sun sunlight exposure

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  • Matti Narkia on 23 Sep 09
     
    Vitamin D treatment in multiple sclerosis. Myhr KM. J Neurol Sci. 2009 Jun 22. [Epub ahead of print] PMID: 19549608 doi:10.1016/j.jns.2009.05.002 Epidemiological evidence combined with clinical and laboratory analyses, and experimental animal models, suggest a possible influence of vitamin D on MS susceptibility as well as clinical disease activity. Supplement with vitamin D may reduce the risk of developing MS. An intervention may also reduce the risk of conversion from a first clinical event suggestive of MS to clinical definite MS, as well as reduce the relapse rate among patients with relapsing remitting MS. More studies are, however, needed to determine optimal dose and serum level for vitamin D, as well as target populations and optimal timing for intervention.
Matti Narkia

Vitamin D and autoimmune rheumatic diseases -- Cutolo 48 (3): 210 -- Rheumatology - 0 views

rheumatology.oxfordjournals.org/...210

2009 March rheumatology study editorial review humans vitamin_D utoimmune rheumatic diseases RA VDR immunomodulation immune immunosuppressive arthritis SLE 25OHD nutrition rheumatoid rheumatoid_arthritis immunosuppression medline

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  • Matti Narkia on 26 Sep 09
     
    Vitamin D and autoimmune rheumatic diseases. Cutolo M. Rheumatology (Oxford). 2009 Mar;48(3):210-2. Epub 2008 Oct 17. PMID: 18930963 doi:10.1093/rheumatology/ken394
Matti Narkia

Lipoxins and resolvins in inflammatory bowel disease. - Inflamm Bowel Dis. 2007 Jun - 0 views

www3.interscience.wiley.com/...HTMLSTART

2007 June study review inflammatory_bowel_disease IBS lipoxins lipoxin resolvins resolvin inflammation immunology dendritic_cells omega-3 omega-6 T-regs Tregs T_cells nutrition medline anti-inflammatory lipid_mediators immune system immune_system

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    Lipoxins and resolvins in inflammatory bowel disease. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC. Inflamm Bowel Dis. 2007 Jun;13(6):797-9. Review. PMID: 17262807
Matti Narkia

Immunomodulation by omega-3 fatty acids - Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec - 0 views

www.plefa.com/...abstract

2007 November study review immunomodulation omega-3 EPA DHA docosanoids resolvins resolvin immune cells cell membrane membranes anti-iflammatory lipid_mediators nutrition medline omega-6 AA eicosanoids

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    Immunomodulation by omega-3 fatty acids. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. Epub 2007 Nov 26. Review. PMID: 18032006 doi:10.1016/j.plefa.2007.10.015
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