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We compare the experts' advice and save you the time. Current Evidence for the Benefits of Melatonin, Dosage, Cautions and Interactions, Buyers Guide, Sleep Tips, Jet Lag Remedies, Seasonal Affective Disorder, Current News and Books.

Benefits of Vitamin D Supplementation Joel M. Kauffman, Ph.D. Journal of American Physicians and Surgeons Volume 14 Number 2 - Summer 2009 Clinical trials show that vitamin D supplementation at higher levels than previously recommended is beneficial for many conditions. It decreases the frequency of falls and fractures, helps prevent cardiovascular disease, and reduces symptoms of colds or influenza. Benefits are also seen in diabetes mellitus, multiple sclerosis, Crohn disease, pain, depression, and possibly autism. Sunlight does not cause an overdose of vitamin D production, and toxicity from supplementation is rare. Dose recommendations are increasing, but appear to be lagging the favorable trial results. A number of common drugs deplete vitamin D levels, and others may limit its biosynthesis from sunlight. People with adequate levels from sun exposure will not benefit from supplementation. While dietary intake is helpful, supplementation is better able to raise serum 25-hydroxyvitamin D , the major circulating metabolite, to the level now thought adequate, 30-50 ng/mL. Where there is inadequate daily sun exposure, oral doses of 1,000-2,000 IU/d are now considered routine, with much higher doses (up to 50,000 IU) for rapid repletion now considered safe.

Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. Jiang F, Bao J, Li P, Nicosia SV, Bai W. J Biol Chem. 2004 Dec 17;279(51):53213-21. Epub 2004 Oct 12. PMID: 15485861 doi: 10.1074/jbc.M410395200 Overall, the study suggests that the down-regulation of telomerase activity by 1,25(OH)2VD3 and the resulting cell death are important components of the response of OCa cells to 1,25(OH)2VD3-induced growth suppression. Progressive shortening of telomere associated with cell divisions limits the life span of normal cells and eventually leads to senescence. To become immortal, human cancers including OCa are invariably associated with activation of mechanism that maintains telomere length. Approximately 85-90% of cancers show reactivation of telomerase. The present study shows that telomerase in OCa cells is down-regulated by 1,25(OH)2VD3. Down-regulation of telomerase is due to decreased stability of hTERT mRNA rather than VDRE-mediated transcriptional repression through the putative VDRE present in the regulatory region of the hTERT gene. It is known that the inhibition of telomerase may lead to a phenotypic lag during which cells would continue to divide until the point at which the telomeres became critically short. This phenomenon may explain why the apoptotic induction by 1,25(OH)2VD3 needs the treatment for more than 6 days. As mentioned in the results, no detectable shortening of telomeric repeats was observed in parental OVCAR3 cells after 9 days of treatment with 1,25(OH)2VD3 (Fig. 4D). This is likely due to the fact that the short telomere (about 3 kb) in OVCAR3 cells is very close to the minimal length required for survival and that cells with detectably shorter telomere may have been selected against apoptosis. It has been shown that transformed human cells enter crisis once the terminal restriction fragment of the telomere reaches a length of about 4 kb. This is insufficient to protect chro

Mango juice is a known health drink and Mango Drinks is also popular all over the world. Mangoes are an excellent source of Vitamins A and C. Mangoes are very rich in fiber content. Mango Juice contain vitamin E which works to regulate and boost you Health hormones. Vitamin E is said to be one of the most beneficial vitamins in order to boost your Health Performance life. SO in order to boost your Health Performance, eat plenty of mangoes regularly. High in vitamins: If you're looking to stave off illness, mango juice has you covered. A cup of mango contains anywhere from 60 to 100 per cent of your daily recommended vitamin C, and about 40-50 per cent of your daily recommended vitamin A. Together, these vitamin complexes also benefit teeth and gums, eye function, neurologic function and better nutrient absorption. Stable blood sugar: Because mangoes and mango juice are so high in natural sugars and fibre, it can work to sustain healthy blood sugar levels. Consider the way you feel in the late afternoon - tired and worn out. This can be a sign of low blood sugar as a result of poor dietary choices or not eating often enough. Drive and performance: One of the known benefits of mango juice is the mango's known ability to help increase Health drive and performance. It's still unknown just how mangoes can boost a lagging Health drive, but it's thought that the fruit's high amount of vitamin E might be what does the trick. Improved libido: What's more, eating a diet high in whole, healthy foods can also help improve libido and Performance, so mango Juice can further add to a better healthy life through a healthier diet overall. How to enjoy this libido food: Peel the mango juice, cut the peach and slice up some strawberries, and feed your woman while she's giving you oral Health Performance . Mango juice contains Vitamin E which helps the hormonal system to function in a better manner. This improves of the your life also Health Performa