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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294

Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. Serhan CN. J Periodontol. 2008 Aug;79(8 Suppl):1520-6. Review. PMID: 18673006 doi:10.1902/jop.2008.080231

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Serhan CN. Pharmacol Ther. 2005 Jan;105(1):7-21. Review. PMID: 15626453 doi:10.1016/j.pharmthera.2004.09.002

Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Serhan CN. Anesthesiol Clin. 2006 Jun;24(2):341-64. Review. PMID: 16927933

Another of my new Year's resolutions put into an informative article! Read this to learn why, it may save your life.

Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation. They are abbreviated as LX, an acronym for lipoxygenase (LO) interaction products. At present two lipoxins have been identified; lipoxin A4 (LXA4) and lipoxin B4 (LXB4)

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN. J Immunol. 2008 Dec 15;181(12):8677-87. PMID: 19050288

While you don't need a New Year as an excuse to begin new or better habits…it seems that a fresh start is easier to accomplish at the beginning of a new year.

Every year we make new resolutions about getting healthier. But at the middle of the first month of the New Year, we lose our motivation and interest towards exercising. Losing weight is every one's dream. However, only few of us stay in shape. Others just curse them and get distracted. In fact, they start making new plans. So, let us take a quick look at the weight loss routine of a passionate and consistent health enthusiast. First Tip: Exercising is not a joke. If you choose a set of exercises that are too much for your present physical condition then you could end up in the hospital. In fact, something worse can happen too. So, preparing a list of exercises before trying them is a wise idea. You can also ask for help from a professional in this regard. An expert can teach you to perform best weight loss exercises.

Cal us now on the Windows support phone number 1-800-261-4071 and get a speedy resolution to any issues bedeviling your windows computer.You can also visit our websites as http://technicalsupportnumberforwindows.com/

March 7, 2005 Boston, MA - The anti-inflammatory effect of fish oils appears to be due to a powerful anti-inflammatory compound called resolvin (resolution-phase interaction product) E1, which is produced from eicosapentaenoic acid (EPA), Dr Makoto Arita (Brigham and Women's Hospital and Harvard Medical School, Boston, MA) and colleagues report in the March 7, 2005 issue of the Journal of Experimental Medicine [1]. Arita writes, "At nanomolar levels, resolvin E1 dramatically reduced dermal inflammation, peritonitis, dendritic cell migration, and interleukin (IL)-12 production.

"Scientists at the University of Granada have identified and characterized for the first time different antioxidant compounds from foods such as olive oil, honey, walnuts and a medicinal herb called Teucrium polium. They have used two new techniques, capillary electrophoresis and high resolution liquid chromatography, that have enabled them to identify and quantify a great part of the phenolic compounds contained in these foods."

15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW. J Exp Med. 2004 Jul 5;200(1):69-78. PMID: 15238606

The relationship between the fatty acid composition of immune cells and their function. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. Epub 2008 Oct 23. Review. PMID: 18951005 doi:10.1016/j.plefa.2008.09.016

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Arita M, Clish CB, Serhan CN. Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. Epub 2005 Aug 10. Review. PMID: 16112645 doi:10.1016/j.bbrc.2005.07.181    

Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. Gangemi S, Pescara L, D'Urbano E, Basile G, Nicita-Mauro V, Davì G, Romano M. Exp Gerontol. 2005 Jul;40(7):612-4. PMID: 15935589 doi:10.1016/j.exger.2005.04.004

Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. Romano M. Inflamm Allergy Drug Targets. 2006 Apr;5(2):81-90. Review. PMID: 16613567

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko R. Br J Pharmacol. 2008 Dec;155(8):1214-23. Epub 2008 Sep 22. PMID: 18806821

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. J Exp Med. 2009 Jan 16;206(1):15-23. Epub 2008 Dec 22. PMID: 19103881 doi:10.1084/jem.20081880

Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. J Immunol. 2007 Mar 15;178(6):3912-7. PMID: 17339491