Li N, Sood S, Wang S, Fang M, Wang P, Sun Z, Yang CS, Chen X.
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Clin Cancer Res. 2005 Mar 1;11(5):2089-96.
PMID
Cyclooxygenase (COX) is an enzyme (EC 1.14.99.1) that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the
Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines.
Scheckel KA, Degner SC, Romagnolo DF.
J Nutr. 2008 Nov;138(11):2098-105.
PMID: 18936204
Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells.
Subbaramaiah K, Michaluart P, Sporn MB, Dannenberg AJ.
Cancer Res. 2000 May 1;60(9):2399-404.
PMID: 10811116
Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X.
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge
Thromboxane A2 (TXA2) is a thromboxane. It is generated from prostaglandin H2 by thromboxane-A synthase. It is also a major component of blood clots. Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane A2.
TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2. Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.