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Studies have shown that eating a diet that is low in calories can lead to a longer and healthier life. This is known as the Calorie Restriction Optimal Nutrition (CRON) or Calorie Restriction diet (CR). This does not mean a starvation diet, since that would be the opposite of healthy.

A signalling pathway that influences how sensitive cancer cells are to the beneficial effects of dietary restriction is described in this week's Nature. Dietary restriction - eating less calories while maintaining essential vitamins and minerals - can extend lifespan, and reduce cancer incidence and growth. But some types of cancer cell are more sensitive to the anti-growth effects of dietary restriction than others, Nada Kalaany and David Sabatini report. The effect hinges on the activity of the phosphatidylinositol-3-kinase (PI3K) pathway. If the pathway is active, dietary restriction has no effect on cancer cells. However, if the pathway is inactive, tumours are sensitive to dietary restriction.

"Researchers from the University of Alabama at Birmingham (UAB) have discovered that restricting consumption of glucose, the most common dietary sugar, can extend the life of healthy human-lung cells and speed the death of precancerous human-lung cells, reducing cancer's spread and growth rate. The research has wide-ranging potential in age-related science, including ways in which calorie-intake restriction can benefit longevity and help prevent diseases like cancer that have been linked to aging, said principal investigator Trygve Tollefsbol, Ph.D., D.O., a professor in the Department of Biology. "These results further verify the potential health benefits of controlling calorie intake." Tollefsbol said. "Our research indicates that calorie reduction extends the lifespan of healthy human cells and aids the body's natural ability to kill off cancer-forming cells.

"ScienceDaily (Dec. 17, 2009) - Researchers from the University of Alabama at Birmingham (UAB) have discovered that restricting consumption of glucose, the most common dietary sugar, can extend the life of healthy human-lung cells and speed the death of precancerous human-lung cells, reducing cancer's spread and growth rate. The research has wide-ranging potential in age-related science, including ways in which calorie-intake restriction can benefit longevity and help prevent diseases like cancer that have been linked to aging, said principal investigator Trygve Tollefsbol, Ph.D., D.O., a professor in the Department of Biology. "These results further verify the potential health benefits of controlling calorie intake." Tollefsbol said. "Our research indicates that calorie reduction extends the lifespan of healthy human cells and aids the body's natural ability to kill off cancer-forming cells.""

Calorie Restriction Diet Plan is being promoted by many medical experts to maintain body weight and size. Calorie restriction diet seems to be one of the most popular diets and it seems to be backed up by great medical results. This is different from fads

"ScienceDaily (Dec. 26, 2009) - Going back for a second dessert after your holiday meal might not be the best strategy for living a long, cancer-free life say researchers from the University of Alabama at Birmingham. That's because they've shown exactly how restricted calorie diets -- specifically in the form of restricted glucose -- help human cells live longer. They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under these same conditions. The reduced glucose caused normal cells to have a higher activity of the gene that dictates the level of telomerase, an enzyme that extends their lifespan and lower activity of a gene (p16) that slows their growth. Epigenetic effects (effects not due to gene mutations) were found to be a major cause in changing the activity of these genes as they reacted to decreased glucose levels. "Western science is on the cusp of developing a pharmaceutical fountain of youth" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study confirms that we are on the path to persuading human cells to let us to live longer, and perhaps cancer-free, lives.""

Calorie-restricted diets are thought to protect against cancer and slow tumor growth, and a new study published in this week's Nature begins to tease out why the measure works for some tumors, and not for others. For almost a century, researchers have known that fasting helps animals live longer and avoid some cancers, "but which type of cancers would be amenable to this approach, from a therapeutic standpoint, is still an open question," said Pier Paolo Pandolfi, a cancer geneticist at Harvard Medical School and Beth Israel Deaconess Cancer Center in Boston, Mass., who was not involved in the study. The study is exciting because it is one of the first to start answering that question at the genetic level, he said.

Mango is a summer delicacy which is consumed worldwide. They are juicy, sweet and act as a natural coolant which is very effective in beating the summer heat. Many varieties of mango are available in the market which have different taste and flavors. They are usually consumed raw and are savored in fresh salads and juices. Mango shakes, pickles, sauces, ice-creams and smoothies are prepared from mangoes which provide different blend of flavor to them. Let us find out the nutritional and health benefits of mango. Nutritional Benefits of Mango Juice provides around 60 calories for 100 grams of its serving. It contains a lot of phytochemicals and nutrients and is a rich source of carbohydrates and fibre. Antioxidants and Vitamins like Vitamin-A, B, C, E and K are present in it. Mango is also a good source of various minerals like Calcium, Zinc, Potassium, Iron, Magnesium and Potassium. Some Main Benefits of Mango Juice - Beneficial for Prevents Cancer: Mangoes are rich in antioxidants which restrict the oxidation of cells in the body. These antioxidants are quercetin, isoquercitrin, astragalin, fisetin, gallic acid and methylgallat. Even Vitamin-A and flavonoids like beta-carotene, alpha-carotene, and beta-cryptoxanthin present in mango prevents lung and oral cancer. Improves Brain and Health Memory: Mango Juice in Vitamin-B6 is found in abundance in mango which helps in improving brain function. It helps in maintaining an efficient nervous system. It is a mood vitamin and enhances mood and controls stress. Beneficial for Aids Digestion: Mangoes are a rich source of dietary fibre which helps in proper digestion. Fibres help with proper bowel movement and keep the digestive tract clean. Mangoes are alkaline in nature thus reduce acidity in the stomach. Various bio-active compounds like Esters, Terpenes and Aldehydes make mangoes even more potent against indigestion. Lowering Cholesterol: Mango Juice are rich in fibre which reduce bad choleste

Hara hatchi bu, the Okinawan people's habit of eating only till they are 80 percent full, is thought to be one of the secrets of their extraordinary health and longevity. In addition to one of the highest percentages of people in the world who live past 100, Okinawans appear to be less prone to heart disease, diabetes and obesity. Indeed, ever since it was discovered in the 1930s that laboratory rats fed a caloric-restricted (CR) diet lived almost twice as long as their well fed counterparts, scientists have pursued caloric restriction research in the hopes of finding novel strategies for extending human life and preventing disease. Given the growing older population at risk for memory problems and the rising rates of obesity, the role of diet in maintaining peak brain performance has taken on added importance.

ScienceDaily (May 26, 2009) - A protein that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that extends lifespan by dietary restriction. The finding, which appears in the May 22, 2009 edition of the online journal PLoS Genetics, provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.

Mangoes are the richest source of most important vitamins (A, C, B, E, K), minerals, dietary fibbers, electrolytes and iron which are mostly required by the for better growth and development as well as being healthy and live life without any diseases and infections. It is liked by all people due to its nice color, taste, flavor and quality health aspects. I have mentioned below the few beneficial aspects of the mangoes which you must know to enhance your interest while eating mangoes: Benefits of Mango juice for Cancer Prevention Mango fruit has antioxidant compounds (such as quercetin, fisetin, astragalin, gallic acid, isoquercitrin, methyl gallate and etc) and lots of enzymes which help in protecting against various body organs cancers like colon, leukemia, breast, stomach, prostate, lungs, cervical, oral cavity cancers and etc. These compounds include, as well as the abundant. Polyphenols found in it acts as an anti inflammatory agent and restricts the growth of cancerous cells. The soluble dietary fibers, pectin found in it has property of decreasing the action of protein (galectin) found in the cancerous cells. Benefits of Mango juice for Heart health It contains highest level of soluble dietary fibers (pectin) and vitamin C which involves in lowering the bad serum cholesterol levels means Low-Density Lipoproteins as well as enhancing the good serum cholesterol levels means High-Density Lipoproteins thus keeps the heart healthy by keeping all the heart problems away. It is the rich source of potassium which involves in controlling the blood pressure thus heart rate. Benefits of Mango juice for Skin It is beneficial for the skin in both ways whether it is eaten or applied externally on the skin. It India juice has antioxidants which make the skin healthy, smooth, glowing and wrinkles free. It clear out the blocked pores and provides solution to get free from the pimples if applied on the face. It makes the skin glowing by reducing the dark spot

Tumours with PI3K activation are resistant to dietary restriction. Nada Y. Kalaany & David M. Sabatini Nature. Published online 11 March 2009 doi:10.1038/nature07782

Avocados may hold a key to longer, better health

Increased dietary protein consumed at breakfast leads to an initial and sustained feeling of fullness during energy restriction compared to other meal times. Heather J. Leidy, Mandi J. Bossingham, Richard D. Mattes and Wayne W. Campbell British Journal of Nutrition (2009), 101:798-803 Cambridge University Press doi:10.1017/S0007114508051532

Its been two days in Oprah aired her special about the amazing anti-aging and weight loss properties of Resveratrol and the results have been amazing. We have had over 500 requests for our free sample bottle of Resveratrol and every day demand continues to grow. Many of our visitors didn't seem to know that Resveratrol not only will give you loads of energy and promote younger looking skin, but it also is amazing for weight loss. As Dr.Oz said on Oprah just a few days ago Resveratrol promotes Calorie restriction naturaly. This means that just by taking a reveratrol supplement or by drinking 12 bottles of red wine a day. You can help promote natural weightloss with one simple pill, its really just that simple. But don't just take our word for it. See what Dr.Oz said about Resveratrol Here.

"My goal is to gather the basic science and apply it to nutrition - NUTRIGENOMICS. What do I mean? How does what we eat signal our genes in the nucleus. By our food choices, we are sending different signals to our genes. High carbohydrate and high fructose intake signals it is summer time and winter is coming -- grow and store the energy (insulin). High fat, low carbohydrate diet with calorie restriction signals our genes that winter is here -- use the stored energy, repair the genes, and slow down growth (i.e. Sirt1/Foxo pathway). The Sirt1/FoxO1 pathway is important as it aids in repairing DNA. Damaged DNA can lead to uncontrolled cellular replication (i.e. cancers). The immune system (phagocytes) has a mechanism to remove old and unwanted cells called apoptosis (cellular death). "

A diet is something that we eat or drink normally, and in some definition it becomes something that is provided for or enjoyed regularly. Diet can also mean restriction of a meal, or reducing calories for purpose of weight loss. While some of us live to eat, others may eat to live, especially those in famine wrought countries.

The HCA Diet, The Human Conjugated Collagen Diet, is an effective and fast-acting weight loss program that is combined with moderate calorie restriction with the administration of human choroidal gonadotropin (HCA). The aim of the HCA Diet is to reduce body fat and improve insulin sensitivity while increasing lean body mass and decreasing total cholesterol. For this reason, many people who are overweight or obese choose to use the HCA Diet to meet their weight loss goals.

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nunn AV, Bell JD, Guy GW. Nutr Metab (Lond). 2009 Apr 16;6:16. PMID: 19371409 doi:10.1186/1743-7075-6-16