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Sean Nash

Regeneron ISEF 2023 - Finalist Project Portal - 6 views

projectboard.world/...categories

fair projects ISEF ISEF2023 HSR HSR-2023 science potential research idea

shared by Sean Nash on 18 May 23 - No Cached
izzy kelly liked it
  • Choose a category to begin
    • Sean Nash
      Sean Nash on 19 May 23
       
      This is a really good way to dive into specific categories and explore the projects that made it to this year's ISEF. What I would do is start with what immediately interests you for now... and pick up some tips. You might get ideas for areas/topics to research. You might see creative methods used in various studies. Pay particular attention to the fact that some utilize equipment only available at a university or corporate lab, but... many also feature creative methods done by students at home or in school labs as well!
    • Sean Nash
      Sean Nash on 19 May 23
       
      Once you get inside projects that you get ideas from, feel free to save them in Diigo for later, or share really interesting ones with others you think might benefit from seeing it.
    • Sean Nash
      Sean Nash on 19 May 23
       
      One final thing: you might also get some tips for elements of their presentation that appeal to you.
Sean Nash

New patch might replace some finger-prick testing of blood sugar - 2 views

www.snexplores.org/...nger-prick-testing-blood-sugar

HSR-2023 HSR ISEF ISEF2023 insulin disbetes transdermal science biology projects potential research idea

shared by Sean Nash on 22 May 23 - No Cached
  • Teen’s color-changing device tests glucose in sweat to signal when insulin is needed
    • Sean Nash
      Sean Nash on 22 May 23
       
      This is from a 2023 ISEF project just last week!
ryleighnyp

BMED010 - Natural and Commercial Moisturizers on Skin Model | Regeneron ISEF 2023 - 2 views

projectboard.world/...ial-moisturizers-on-skin-model

ISEF fair project

shared by ryleighnyp on 23 May 23 - No Cached
  • ryleighnyp on 23 May 23
     
    This is a good example of data collection, experimental design, and presentation.
Sean Nash

MyCo Planet - About Us - 0 views

mycoplanetkc.com/about-us

MyCoPlanet local fungi business resource company mushrooms technology science KC KansasCity NKC HSR potential research idea biology HSR-2023

shared by Sean Nash on 20 Dec 23 - No Cached
  • Sean Nash on 20 Dec 23
     
    Local KC company growing edible fungi - bring in a rep to tell us about what they do - potential source of future research projects
Sean Nash

What Exactly Is 'New Car Smell'? - 0 views

www.mentalfloss.com/...what-exactly-new-car-smell

HSR-2023 HSR science VOCs environmental questions potential research idea chemistry car smell

shared by Sean Nash on 04 Feb 24 - No Cached
  • Sean Nash on 04 Feb 24
     
    I feel like this could form the basis of a student project if we could find a way to measure the VOCs inside the cabin of vehicles and get a dealership or two to give us access.
Sean Nash

Large Data Sets - Society for Science - 1 views

www.societyforscience.org/...large-data-sets

resources HSRTC SFS research data sets society SCI-I projectdevelopment questioning statistical analysis HSR-2023 HSR science

shared by Sean Nash on 23 Jun 23 - No Cached
  • Locate a data set that interests you, see how others students have used large data sets in their research, and learn about current scientific studies fueled by big data.
  • Sean Nash on 23 Jun 23
     
    Another really solid pathway into project development is the examination and study of already existing large data sets. I have seen excellent projects that didn't even require students to generate their own data. Instead, they utilize already existing data to answer questions others may not have posed before in relation to that data set. At the very least, becoming familiar with these lines of research can help you discover a line of research that is most compelling to you!
Sean Nash

Learning in Plants: Lessons from Mimosa pudica - 4 views

www.frontiersin.org/...full

Mimosa learning plants botany research SCI-I science student lab potential research idea biology HSR HSR-2023

shared by Sean Nash on 23 Jun 23 - No Cached
  • there is a lack of observational data on the behavior of plants
  • Observational research allows the researcher to establish baseline activity and response levels of the subject
  • Perhaps the first study of learning in plants was a habituation experiment reported by Pfeffer (1873) using the sensitive plant Mimosa. In this experiment, repeated mechanical stimulation of leaflets led to a decrease in sensitivity
  • ...12 more annotations...
  • the question naturally arises as to whether Mimosa can discriminate between stimuli. This was answered in the affirmative by Holmes and Gruenberg (1965) whose experimental design included a drop of water and finger touch as stimuli
  • the results suggest that Mimosa can discriminate between stimuli
  • Thomas performed an experiment on classical conditioning in Mimosa that took advantage of the finding that, under field conditions, the leaflets of Mimosa slowly drop as dusk approaches and slowly rise at dawn (personal communication). In the experiment, the CS was turning on the light in the growth chamber and the US was touching selected leaflets. Thomas found that leaflets in the paired condition showed conditioning compared to a light only or alternating stimulation condition. This finding should be replicated with controls for pseudoconditioning.
  • Given the importance of the Gagliano et al. (2014) experiment and the failure to replicate some previous experimental results it is critical that the Gagliano et al. (2014) results be repeated by an independent laboratory.
  • In addition to Mimosa, habituation has been found in the carnivorous plant Drosera (sundew
  • Applewhite (1975) cites an experiment by Darwin reportedly showing habituation in the passion flower (Passiflora gracilis). During this experiment, when Darwin mechanically stimulated the passion flower tendrils, the tendrils no longer responded after 54 h of training.
  • Abramson et al. (2002) investigated the use of bioelectrical potentials as a method to explore plant behavior.
  • In an interesting article, Karpinski and Szechynska-Hebda (2010) discuss the intellect of plants from memory to intelligence. By studying recall, the researcher investigates a host of independent variables and that are solidly anchored to a set of dependent variables. This study focused on recall at the cellular level rather than as an externally observable behavior. The discussion of plant learning at various levels, from cellular to organismal and from different scientific fields is exactly what is advocated for in this article
  • There is also interest from behavioral scientists seeking to determine whether the similarities and differences in learning found among invertebrates and vertebrates could also be found in plants (Warden et al., 1940; Applewhite, 1975; Abramson et al., 2002; Guiguet, 2013).
  • The majority of early plant studies used the Sensitive plant (M. pudica). Mimosa has much to recommend it for learning studies. They are easy to maintain, much is known about its natural history, and they have a visible leaf closure response to external stimuli. However, there are drawbacks in the use of Mimosa, for example, it takes about 15 min for a leaf to recover (Holmes and Gruenberg, 1965) and not much is known about its genome in contrast to model species such as Arabidopsis thaliana whose entire genome is known.
  • In the following section we will focus on methods to develop studies utilizing habituation, sensitization, and classical conditioning techniques. Instrumental and operant conditioning will not be covered because at this time there are no Mimosa studies in these areas; although one can envision a situation where the opening and closing of a leaf can be detected electronically. Once detected, the response would produce a consequence such as an airpuff or changes in light intensity.
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      The remainder of this comprehensive article is to outline the main lines of research in this area:
  • Learning in Plants: Lessons from Mimosa pudica
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      This well-compiled article does a really nice job of outlining the history of study regarding plant behavior. It also suggests model organisms for study. Mimosa is a favorite of mine as their response is VERY rapid and quite visible for a plant! There are all sorts of feasible project ideas that could arise from this area of research.
Sean Nash

Hand dryers can infect clean hands with bathroom germs - 3 views

www.snexplores.org/...rs-paper-towels-bathroom-germs

ISEF2023 ISEF HSR HSR-2023 hands science biology germs microbes

shared by Sean Nash on 22 May 23 - No Cached
  • In tests, the hot-air machines spread far more microbes than paper towels
    • Sean Nash
      Sean Nash on 22 May 23
       
      Another ISEF project from just last week!
ryleighnyp

The effects of grounding (earthing) on inflammation, the immune response, wound healing... - 2 views

www.ncbi.nlm.nih.gov/...PMC4378297

potential research idea HSR HSR-2023

shared by ryleighnyp on 23 May 23 - No Cached
  • ryleighnyp on 23 May 23
     
    This is something I'm interested in and it has lots of potential for projects.
ryleighnyp

Electrical grounding technique may improve health outcomes of NICU babies -- ScienceDaily - 2 views

www.sciencedaily.com/...170803120627.htm

HSR HSR-2023 potential research idea

shared by ryleighnyp on 07 Jun 23 - No Cached
Sean Nash liked it
  • "What we can conclude is that a baby's autonomic nervous system is able to sense the electrical environment and it seems as though a baby is more relaxed when grounded,"
  • redesigning incubators to ground babies and cancel out the electrical field
  • ryleighnyp on 07 Jun 23
     
    I think a possible research idea could be redesigning NICU incubators to allow for less electromagnet interference with the babies with the use of grounding.
  • Sean Nash on 07 Jun 23
     
    Interesting, for sure. Two things... the actual measurements they made on children (skin tests, etc.) are a no-go for us. I'm not sure what our model system could be for checking the electrical outputs of whatever design changes were made. We would need to know a lot more about the current setup in NICUs. There is no doubt a lot of design in how things are currently set up. Essentially: why things are set up the way they are right now? You would have to know every variable currently considered, and then look for spots where simple changes can be made. Second thing: go back to the ISEF categories in Engineering and check out how those projects look at the national level. Just go get a feel. Engineering is a bit different from typical "hypothesis testing" seen in most natural sciences. Very cool, but different. Give it a look.
katherine-medina

In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC9697812

potential research idea HSR-2023 rat-experiments Amygdalin cancer-fighting Natural-remides

shared by katherine-medina on 11 Jun 23 - No Cached
Sean Nash liked it
  • ]. Approximately 80% of all medications approved by the FDA in the last three decades have been derived from natural sources
  • Transdermal drug delivery is a promising route for cancer treatment compared with the oral route due to its low side effects and improved efficacy and selectivity
  • All ALN formulations containing DDP exhibited a higher percent of EE and smaller particle size and PDI than those that did not have DDP at the molar ratio investigated.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      If I am to do my research project over the affects of amygdalin patches on cancer, I will need to keep this section of text in mind.
  • ...9 more annotations...
  • The optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) at a higher rate (p < 0.05) compared with free amygdalin solution and free tamoxifene suspension.
  • that the optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) compared with the DMBA control.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      reduced carcinoma in comparison to control group
  • . The value of the zeta potential indicated a negative surface charge, which is considered advantageous for transdermal drug delivery and for electrostatic stabilization due to the electrostatic repulsions between vesicles
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Good to note.
  • 3. Materials and Methods3.1. MaterialsAmygdalin was attained from Nature’s Only Choice Company (Tbilisi, GA, USA). Sigma Aldrich (Agitech Company, Cairo, Egypt) provided Tween 60, Span 60, cholesterol, 7, 12-dimethylbenz[a] anthracene (DMBA), triethanolamine, and dihexadecyl phosphate. Carbopol 934, methanol, acetone, and chloroform were attained from Corner-Lab Company (Cairo, Egypt).
  • Histological examination of the oral tamoxifen suspension treated group (Figure 7C) revealed the presence of hyperkeratosis and acanthosis in the surface epithelium of the epidermis with signs of a diffuse inflammatory response and edema in the dermis and sub-cutaneous tissue.
  • Histological examination of the optimum ALN gel treated group (Figure 7F) showed clearly healed skin with normal covering epithelium and marked improvement in all signs of the epidermis and dermis that were better than those of the oral amygdalin solution. These results confirmed the effectiveness of amygdalin loaded niosomes gel as a cancer therapy in vivo.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Cool, so they tested and confirmed that ALN gel does work to treat cancer of the skin.
  • Histological examination of the optimum ALN gel-treated group (Figure 8B) showed clearly healed skin with normal covering epithelium.
  • The group treated with plain niosomes gel showed MCV nearly similar to that of the DMBA control group.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      SO the niosome gel doesn't do much.
  • The optimum ALN gel enhanced the permeation of amygdalin into deep skin layers and showed significant anti-tumor activity compared with oral tamoxifen.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      I think that Amygdalen could be one of my research topics for this upcoming year.
  • katherine-medina on 11 Jun 23
     
    A really cool study that showed that Amygdalin in a gel form can prove to be very sucsessful at healing tumors from the epidermis.
Sean Nash

Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relativ... - 1 views

genesenvironment.biomedcentral.com/...s41021-018-0114-3

radiation cancer genes environment fulltext research paper SCI-I potential research idea biology chemistry physics statistical analysis questions HSR HSR-2023 environmental

shared by Sean Nash on 23 Jun 23 - No Cached
  • individuals
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      These "individuals" could just as easily be plants of lower invertebrates (as model organisms at this level). This is fascinating to me. There is no doubt that we would be limited in our ability to work with ionizing radiation, but that's not to say a project couldn't be developed along these lines. I never cease to be amazed at what a motivated student can resourcefully come up with when their passion for a particular line of research is so high.
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