Skip to main content

Home/ Honors Scientific Research 2023-2024/ Group items tagged hands

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Sean Nash

Hand dryers can infect clean hands with bathroom germs - 3 views

www.snexplores.org/...rs-paper-towels-bathroom-germs

ISEF2023 ISEF HSR HSR-2023 hands science biology germs microbes

shared by Sean Nash on 22 May 23 - No Cached
  • In tests, the hot-air machines spread far more microbes than paper towels
    • Sean Nash
      Sean Nash on 22 May 23
       
      Another ISEF project from just last week!
katherine-medina

Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated f... - 0 views

journal-inflammation.biomedcentral.com/...1476-9255-7-60

lupeol anti-inflammatory HSR-2023 botany rat-experiments

shared by katherine-medina on 12 Jun 23 - No Cached
Sean Nash liked it
  • The latex collected from its stem bark is used for several purposes including anti-inflammatory properties and presents among its bioactive constituents the pentacyclic triterpene lupeol.
  • administered with LA,
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      they were trying to see if it could work as a prevenatitive treatment
  • carrageenan and dextran,
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      This causes inflammation
  • ...13 more annotations...
  • the effect of a very low dose of LA (0.1 mg/kg) was potentiated by the same dose of pentoxifylline (PTX), a known TNF-alpha inhibitor. L
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      Essentially once they put pentoxifylline into the rat the LA activated.
  • The anti-inflammatory effect of LA probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      So, the LA helped the body with inflammation due to its interaction with the opioid system.
  • rich in triterpenes
  • Carrageenan-induced mice paw edema
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      Cool to understand that these next two paragraphs are about how to induce inflammation
  • LA (10, 25 and 50 mg/kg, i.p.) reduced both phases of the formalin test, and the results were significant at the two higher doses. However, the effects were mainly on the 2nd phase with 61% inhibition, whereas the 1st phase was inhibited by 41% at the LA dose of 50 mg/kg, i.p. The naloxone pretreatment completely reversed the LA effect, in the 1st and 2nd phases, indicating the participation of the opioid system in LA antinociceptive and anti-inflammatory actions.
  • LA injected 30 min before carrageenan significantly decreased the carrageenan-induced neutrophil migration in a dose-dependent manner. The LA inhibitory effect against carrageenan-induced migration was about 52, 79 and 90%, at the doses of 1, 10 and 20 mg/kg, i.p., respectively
  • On the other hand, while no significant enzyme release was observed with LA at the concentrations of 1, 10 and 25 μg/mL, a small but significant LDH release (around 2 times) was detected with the higher LA concentration (50 μg/mL), probably related to the presence of 0.2% Tween 80.
  • The results show that LA at the concentrations of 50, 100 and 200 μg/mL presents no radical scavenging capacity. On the contrary, vitamin E used as the reference drug significantly decreased the absorbance value, as related to controls
    • katherine-medina
      katherine-medina on 12 Jun 23
       
      LA can sadly not kill the free radicals that tend to disrupt and kill DNA and other parts of the cell.
  • In the carrageenan-treated groups pretreated with LA (50 mg/kg, i.p.) or indomethacin (10 mg/kg, i.p.), there were significant reductions of iNOS expressing cells.
  • Lupeol is found in several other species and its antinociceptive and anti-inflammatory activities have been already demonstrated [24–28]. It is accepted that the anti-inflammatory property of lupeol often accompany its immune modulatory and anti-tumor action
  • lupeol acetate presents an anti-inflammatory activity by regulating TNF-alpha and IL-2 specific mRNA, besides upregulating the synthesis of IL-10 mRNA [31].
  • In the present work, we showed that lupeol acetate (LA, 93.2% purity) isolated from the H. drasticus latex presented a potent anti-inflammatory action, in several models of inflammation in mice
  • These authors concluded that lupeol possessed an anti-inflammatory activity which is probably related to its ability to prevent the production of pro-inflammatory mediators, such as TNF-α and IL-1β.
  • katherine-medina on 12 Jun 23
     
    This study is a good one to go back to if you are curious about alternative types of anti-inflammatory plants.
  • Sean Nash on 15 Jun 23
     
    The carrageenan here (and the fact that you seem interested in the biochemical realm) made me think of a supplement my mom recently asked me to scope out for her (Arteriosil). It also contains a seaweed extract (rhamnan sulfate) Her doctor was recommending it for macular degeneration. Here is the product: https://shop.calroy.com/product/arterosilhp/?gclid=Cj0KCQjw7aqkBhDPARIsAKGa0oKoQchIRSlzL1_PikNwT71f1BmUVgbIM7sXUQS_lJKaGVSCT4O5R7EaAmaUEALw_wcB Here is one study from the NIH: https://pubmed.ncbi.nlm.nih.gov/32344720/
Sean Nash

Study shows experimental evidence of an altruistic nature in small convict cichlid fish - 0 views

phys.org/...e-altruistic-nature-small.html

ethology behavior behavioralscience convictcichlid cichlid fish research SCI-I model organism study nature science potential research idea biology HSR HSR-2023

shared by Sean Nash on 23 Jun 23 - No Cached
  • Study shows experimental evidence of an altruistic nature in small convict cichlid fish
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      This is a big favorite model organism for me and for a handful of former students. They are fascinating little fish with complex behaviors. However, the struggle is always: studies with vertebrate model organisms are always subject to far more scrutiny and paperwork. You have to prove beyond the shadow of a doubt that your study is not invasive, and you have a proper plan for their care before/during/after experimentation. I am actually switching out the back aquarium (that previously had African Cichlids) for these in August.
1 - 4 of 4
Showing 20▼ items per page