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katherine-medina

Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain is associated with ... - 1 views

www.science.org/...sciadv.adf6232

Alzheimer's-disease Research-idea brain HSR-2023 Human

shared by katherine-medina on 27 May 23 - No Cached
  • Genetic factors contribute substantially to the pathological process of AD as demonstrated by the fact that the genetic heritability in AD is in the range of between 60 and 80% (10).
  • however, whether the variants alter the level of 3-OST-1 enzyme activity to change the structure of HS remains unknown
    • katherine-medina
      katherine-medina on 27 May 23
       
      Good to note what exactly the article remains unsure about
  • The synthesis of additional 13C-labeled calibrants to cover these three reported 3-O-sulfated tetrasaccharides will be the subject for future study.
    • katherine-medina
      katherine-medina on 27 May 23
       
      LOOK INTO THIS PART CAYSE THEY ARE SAYING THAT THEY ARE NOT FULLY SURE
  • ...4 more annotations...
  • the elevation of total HS and the percentage of the 3-O-sulfated domain in HS.
  • HS and tau revealed that the sugar mainly interacts with the proline-rich region 2, a repeat domain 2 in tau protein
  • Further analysis of the distribution of 3-O-sulfated HS from different areas of AD brains will be of interest and the subject for a subsequent study.
  • Experimental design
    • katherine-medina
      katherine-medina on 27 May 23
       
      READ THIS IF THIS TOPIC COMES BACK UP AGAIN
  • katherine-medina on 27 May 23
     
    A interesting study about a sulfate that suggests that Alzheimer's is genetic
Isabella Tungjaroenkul

The new human pangenome could help unveil the biology of everyone - 0 views

www.sciencenews.org/...angenome-biology-dna-diversity

HSR HSR-2023 biology DNA RNA pangenome

shared by Isabella Tungjaroenkul on 13 Jun 23 - No Cached
Sean Nash liked it
  • Being able to assess where some people have extra DNA and others are missing DNA, called structural variants, adds a more nuanced view of human genetics, O’Connor says, revealing more of its complexity (SN: 4/10/09).
  • Conversely, another study found that the very short arms of certain chromosomes, including chromosomes 13, 14 and 21, are becoming more like each other as they swap DNA.
Hannah Herrera

Space travel alters gene expression in white blood cells, weakening our immune system -... - 1 views

blog.frontiersin.org/...on-leukocytes-changes-in-space

questions space physics gene alterations astronauts

shared by Hannah Herrera on 24 Jun 23 - No Cached
  • Space travel alters gene expression in white blood cells, weakening our immune system
    • Hannah Herrera
      Hannah Herrera on 24 Jun 23
       
      very interesting article, there is a conclusion with insights to this underlining issue in the "read original paper" link in red. I overall think its a ear pricking issue that has yet to be solve or given the clear conclusion as to why it happens in the first place.
  • pre-flight strength: the length of this period is likely to depend on age, sex, genetic differences, and childhood exposure to pathogens.
  • These observations suggest that our immune system might be weakened by space travel.
    • Hannah Herrera
      Hannah Herrera on 24 Jun 23
       
      could it have a possible connection with the strong gravitational pull while actually going up to space? (like the continuing feeling of a steep rollercoaster drop).
  • ...1 more annotation...
  • change in gene expression of leukocytes under microgravity is triggered by ‘fluid shift’, where blood plasma is redistributed from the lower to the upper part of the body, including the lymphatic system. This causes a reduction in plasma volume by between 10% and 15% within the first few days in space. Fluid shift is known to be accompanied by large-scale physiological adaptations, apparently including altered gene expression.
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