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Kenuvis Romero

Journal of Cerebral Blood Flow & Metabolism - Multiple Microvascular and Astroglial 5-Hydroxytryptamine Receptor Subtypes in Human Brain[colon] Molecular and Pharmacologic Characterization - 0 views

  • Physiologic and anatomic evidence suggest that 5-hydroxytryptamine (5-HT) neurons regulate local cerebral blood flow and blood-brain barrier permeability.
  • capillary endothelial cells exhibited mRNA for the h5-HT1D and for the 5-HT7 receptors whereas microvascular smooth muscle cells, in addition to h5-HT1D and 5-HT7, also showed polymerase chain reaction products for h5-HT1B receptors. Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures. In contrast, messages for all 5-HT receptors tested were detected in human brain astrocytes with a predominance of the 5-HT2A and 5-HT7 subtypes. In all cultures, sumatriptan inhibited (35–58%, P < .05) the forskolin-stimulated production of cyclic AMP, an effect blocked by the 5-HT1B/1D receptor antagonists GR127935 and GR55562. In contrast, 5-carboxamidotryptamine induced strong increases (≥ 400%, P < .005) in basal cyclic AMP levels that were abolished by mesulergine, a nonselective 5-HT7 receptor antagonist. Only astroglial cells showed a ketanserin-sensitive increase (177%, P < .05) in IP3 formation when exposed to 5-HT. These results show that specific populations of functional 5-HT receptors are differentially distributed within the various cellular compartments of the human cortical microvascular bed, and that human brain astroglial cells are endowed with multiple 5-HT receptors. These findings emphasize the complex interactions between brain serotonergic pathways and non-neuronal cells within the CNS and, further, they raise the possibility that some of these receptors may be activated by antimigraine compounds such as brain penetrant triptan derivatives.
Kelly Boushell

GoAnimate4Schools - 103 views

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    This is a superb site for GoAnimate and is specially designed to be used in schools. Make amazing animations in minutes. The teacher account allows you to administrate your class accounts and access their work. http://ictmagic.wikispaces.com/Video,+animation,+film+&+Webcams
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    GoAnimate4Schools is an entirely private space for you and your students to let your creativity flow. A quiet place for your students to enjoy what's great about online creation tools, without the dangers of being out in the open Web. As a teacher on GoAnimate4Schools you get full access to all our tools. No virtual currency needed. And if you upgrade your School to our SchoolPlus program, all your students get the same unlimited access.
James Davis

An Apple for Your Teacher - WSJ.com - 0 views

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    Money for technology is flowing at the same time money is being pulled back from traditional programs, leaving some districts with difficult choices
Joe Wheaton

Hans Rosling | Profile on TED.com - 23 views

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    Rosling's presentations are grounded in solid statistics (often drawn from United Nations data), illustrated by the visualization software he developed. The animations transform development statistics into moving bubbles and flowing curves that make global trends clear, intuitive and even playful. During his legendary presentations, Rosling takes this one step farther, narrating the animations with a sportscaster's flair.
Jon Tanner

What's the point of media specialists...? on School Library Journal - 49 views

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    "Joyce Valenza Ph.D On the librarian: What's the point . . ? The Twitter conversation April 30, 2009 @karlfisch: What's the point of having a media specialist if they aren't specialists in the media forms of the day? I was nearly finished copying and pasting, figuring out how best to post Tuesday's Twitter conversation, when I discovered that Karl Fisch (@karlfisch), who kinda started it all, already took care of that. (You likely know of Karl's very popular and provocative videos.) I am still not sure how best to frame this conversation on the place of the information/media specialist in today's school. What is clear is that a lot of smart people--people who are out there teaching, speaking, moving, and shaking--are disappointed in what they see when they see school librarians. Either we have a perception problem or we need to do some serious retooling. I'd say we have to deal with both. In a hurry. Being an information (or media) specialist today means being an expert in how information and media flow TODAY! It is about knowing how information and media are created and communicated. How to evalute, synthesize, and ethically use information and media in all their varied forms. It is about being able to communicate knowlege in new ways for new audiences using powerful new information and communication tools. Forgive me if it hurts. In my mind, if you are not an expert in new information and communication tools, you are NOT a media specialist for today. Tuesday's conversation happened in the open, on Twitter. We need to be aware that these conversations are happening where we cannot hear them--at conferences, at Board and cabinet meetings. We also need to make sure that our voices are heard and that we hear the voices of others in places like Twitter, where so many educational leaders and thinkers are chatting about us and many other things. I've selected the remarks that resonated loudest for me. (I've shuffled a bit, but you can visit Karl'
Nichel Smith

Blogging Process - Find Your Flow - 35 views

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    Brian Grenier wrote a blog post back in 2007 that I think I missed where he asks the question how do you write a blog post?Miguel Guhlin just wrote a great post in response to Brian's thoughts. In my COETAIL course yesterday we had a great discussion around how blogging was going for those in the cl
Nigel Coutts

Hold your ideas lightly - The Learner's Way - 35 views

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    The history of teaching is littered with ideas that have come and gone. In their day each was the new bright hope, set to transform what we do as teachers and how our students learn. Each new idea had its supporters and detractors and each in turn was replaced by an alternative or simply disappeared from view. Those who have experienced this ebb and flow of ideas have learned to approach the shiny and the new with caution and yet we have all encountered ideas that are so compelling it is difficult to ignore. How might we approach new ideas and innovative practices in ways that ensure our students benefit?
Martin Burrett

Planning Flow - 53 views

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    "An editable planning template with question prompts. Use to ensure your planning includes everything and replace the default with your answers to the questions to make a quick lesson plan."
Michele Brown

Poetry Idea Engine | Writing with Writers | Scholastic.com - 46 views

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    Get your poetry juices flowing with the Poetry Idea Engine. Created with GoCyberCamp, this activity will allow you to write haikus, free verse, limericks, and more!
Lauren Rosen

Flow Chart Maker & Online Diagram Software | Lucidchart - 10 views

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    Great tool for all sorts of charts and diagrams built collaboratively. Free for K-12 educators. Integrates with google drive.
Roland Gesthuizen

True believer keen on spreading the social media word - 19 views

  • ''Trying to take all of what is happening on Twitter in is like drinking from a fire hydrant,'' he says. ''So you end up thinking of it as a stream that's flowing past you; you throw your hook in and pull out an idea and if it's good then you let it go and let other people share in it.''
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    "ROLAND Gesthuizen describes himself as a social media evangelist. His passion for social media and Twitter in particular extends beyond the global power of tapping into and sharing ideas. For his students it has brought the outside world to his classroom in a way that could never be imagined."
Marc Patton

G.A.M.E. Kae Novak - YouTube - 2 views

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    Channel for G.A.M.E. and Games Based Learning MOOC
Michele Brown

mathispower4u - Math Tutorials - YouTube - 6 views

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    Collection of tutorial videos primarily covering topics found in middle school and high school math courses. 
Dan Bench

Dan Pink's Drive: A Scholarly Book Review - 20 views

  • we have a responsibility to ensure that our students develop skills to perform heuristic tasks in order to compete in the job market.
  • According to SDT the three basic psychological needs for motivation are competence, where one feels effective and efficacious; relatedness, where one feels close and connected to others; and autonomy, where one feels causation and ownership of one’s behavior
  • Starkey (2011) suggests that creativity is the penultimate learning experience and that sharing the knowledge is the ultimate goal (p. 25), a concept supported by Siemen’s (2004) connectivism learning theory, where learning and knowledge rests on a number of opinions that when connected allows us to know more (2004).
  • ...2 more annotations...
  • Overall, promoting mastery through flow-friendly classrooms is certainly a reality and adds weight to the Motivation 3.0 model
  • So as Lent (2010) suggests, providing opportunities for students to be part of something larger than themselves is clearly a viable proposition where students pursue “purpose” goals that serve others as opposed to “profit” goals, such as good grades, that only serve themselves (Pink, 2011, p. 142).
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