Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.
Journal of Child Neurology - Amplitude-Integrated EEG is useful in predicition of Neurodevelopmental Outsome in Full-Term Infants with Hypoxic-Ischemic Encephalopathy: A Meta-Analysis
Imperial College London sponsored trial in newborn infants with perinatal asphyxial encephalopathy assessing whether a combination of hypothermia and inhaled xenon preserve cerebral metabolism and structure.
Completed Zhengzhou University study to investigate whether systemic hypothermia induced up to 10 hrs after birth would improve the neurodevelopmental outcome at 18 months in infants with moderate or severe HIE.
Hundreds of babies in the world are being treated with brain cooling to prevent brain injury after they lose oxygen at birth. This study will use the newly developed information from the magnet resonance image to determine the actual temperature of the brain. This will enable researchers to determine if the brain is being uniformly cooled and if techniques that provide cooling need to be changed to improve the injury prevention from cooling
New England Journal of Medicine abstract of study to evaluate the effects of induction of moderate hypothermia in infants who had perinatal asphyxia. Study concluded that Induction of moderate hypothermia for 72 hours in infants who had perinatal asphyxia did not significantly reduce the combined rate of death or severe disability but resulted in improved neurologic outcomes in survivors. (Current Controlled Trials number, ISRCTN89547571 [controlled-trials.com] .)
Objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy.
PubMed Study Abstract: Ten indicators available during the first two hours of life, such as clinical criteria of neonatal distress and postnatal arterial blood gases, were compared
with the neonatal neurological course in sixty full term newborns with significant birth asphyxia in order to test their value for the diagnosis and the short-term prognosis of severe birth asphyxia. Birth asphyxia was defined as severe when it was followed by symptoms of moderate or severe post-asphyxial encephalopathy.
First and original facility to specialize in the neurologic applications of hyperbaric oxygenation and the potentially recoverable brain, treating stroke, coma, traumatic brain injury, Cerebral Palsy, anoxic encephalopathy and multiple sclerosis patients.
Clinical trial being sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD to evaluate whether induced whole-body hypothermia initiated between 6-24 hours of age and continued for 96 hours in infants ≥ 36 weeks gestational age with hypoxic-ischemic encephalopathy will reduce the incidence of death or disability at 18-24 months of age.
Future planned study being conducted by the University of California to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
NIH PUbMed Abstract of Russian study documenting the Physical and neurological state of the newborn afer perinatal asphyxia.This paper is presented as modern conceptions about asphyxia origin, risk factors, neurological and systemic complications for child nervous system and organism.
Trakya University School of Medicine, Turkey study to evaluate the impact of the Neonatal Resuscitation Program (NRP) on morbidity and mortality of newborn infants with perinatal asphyxia. The study concluded that after Neonatal resuscitation (RP) courses, the number of patients with perinatal asphyxia and with no resuscitation and also the duration of hospitalization decreased significantly, whereas the first minute Apgar scores increased significantly.
PEDIATRICS Journal Abstract of study to determine whether serial head circumference measurements and decreased rate of head growth in asphyxiated full-term newborns during the first few months of life may predict the development of eventual microcephaly.
PubMed Abstract of study to assess the relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy
PubMed Abstract of study to determine whether hyperoxaemia and/or hypocapnia during the first 2 hours of
life add to the risk of brain injury after intrapartum asphyxia"