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Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

www.nytimes.com/...al-of-transplanted-uterus.html

shared by Casey Finnerty on 11 Apr 16 - No Cached
  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
  • ...11 more annotations...
  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Whitney Hopfauf

Electron-beam pasteurization of raw oysters may reduce viral food poisoning - 0 views

www.sciencedaily.com/...130430151648.htm

raw food poisoning

shared by Whitney Hopfauf on 30 Apr 13 - No Cached
  • FDA already has approved the use of electron beam technology as a pathogen intervention strategy to control the naturally occurring Vibrio vulnificus bacterial pathogen in shellfish.
    • Whitney Hopfauf
      Whitney Hopfauf on 30 Apr 13
       
      Good that it has already been approved by the FDA... step in the right direction
  • Praveen said she and the other researchers also chose the viral pathogens as opposed to bacterial as they were more difficult to treat and also require a host species.
  • if a serving size of 12 raw oysters were contaminated with approximately 100 hepatitis A and human noroviruses, an e-beam dose of 5 kGy (kilograys) would achieve a 91 percent reduction of hepatitis A infection risks and a 26 percent reduction of norovirus infection risks.
  • ...6 more annotations...
    • Whitney Hopfauf
      Whitney Hopfauf on 30 Apr 13
       
      Pretty significant except it still doesn't make me want to eat raw shellfish
  • how electron-beam pasteurization of raw oysters may reduce the possibility of food poisoning through virus.
  • results of this study will be published in the June
  • using a human norovirus surrogate called murine norovirus
  • uses commercial electricity
  • green technology because no chemicals are involved."
Casey Finnerty

How Scientists Stopped Klebsiella Pneumoniae: Deadly Superbug Killed 6 At NIH Clinical ... - 1 views

www.huffingtonpost.com/...l-center-deadly_n_1822695.html

microbiology antibiotic resistance

shared by Casey Finnerty on 29 Jan 13 - No Cached
  • 18 people harbored the dangerous germ, and six died of bloodstream infections from it. Another five made it through the outbreak only to die from the diseases that brought them to NIH's world-famous campus in the first place.
  • Infections at health care facilities are one of the nation's leading causes of preventable death, claiming an estimated 99,000 lives a year.
  • KPC has emerged over the past decade to become a fast-growing threat in intensive care units, spreading easily between very ill people and killing half of those it sickens.
  • ...3 more annotations...
  • KPC was transmitted three separate times from Patient No. 1, and then spread more widely.
  • Test after test never found the bug on hospital workers' hands.
  • "There's better technology becoming available for your hospital to prevent these bacteria from spreading, and this is what you should expect from your hospital," he said.
  • Katelyn Madigan on 29 Jan 13
     
    I agree that it is wise to broaden the scope of infection control to custodial workers, since they would often be in contact with several of the inanimate objects in the room. This is really shown when they were unable to find the superbug on the "hospital workers' hands." Did they test everyone?
Megan Goldman

Preliminary Characterisation of Tumor Necrosis Factor Alpha and Interleukin-10 Response... - 0 views

www.ncbi.nlm.nih.gov/...PMC3602058

shared by Megan Goldman on 30 Apr 13 - No Cached
  • Megan Goldman on 30 Apr 13
     
    Bernhard Kaltenboeck, Editor Abstract Debilitating infectious diseases caused by Chlamydia are major contributors to the decline of Australia's iconic native marsupial species, the koala ( Phascolarctos cinereus). An understanding of koala chlamydial disease pathogenesis and the development of effective strategies to control infections continue to be hindered by an almost complete lack of species-specific immunological reagents.
Jenna Veldhuizen

Fighting disease from within the mosquito: New techniques to help halt the spread of di... - 0 views

phys.org/...-mosquito-techniques-halt.html

mosquito disease

shared by Jenna Veldhuizen on 12 Apr 13 - No Cached
  • When infected with the bacteria Wolbachia, mosquitoes are unable to spread viruses such as dengue
  • by introducing an insecticide resistance gene alongside the Wolbachia bacteria into the mosquito, that the insects pass on the disease-blocking bacteria to other mosquitoes faster
  • Our results show that Wolbachia-based strategies could hold the key to a cheap and sustainable approach to disease control
  • Amy Jorgenson on 12 Apr 13
     
    This in an interesting application in slowing the spread of diseases such as dengue and yellow fever, but one also has to wonder what this will do to the mosquito population as it reduces the mosquito's ability to lay viable eggs. How controlled will this application be and how often will it be utilized?
Casey Finnerty

'We Have a Limited Window of Opportunity': CDC Warns of Resistance 'Nightmare' | Wired ... - 0 views

www.wired.com/...cre-cdc

microbiology antibiotic resistance

shared by Casey Finnerty on 07 Mar 13 - No Cached
  • “We have a very serious problem, and we need to sound an alarm.”
  • Healthcare institutions in 42 states have now identified at least one case of CRE. The occurrence of this resistance in the overall family of bacteria has risen at least four-fold over 10 years. In the CDC’s surveillance networks, 4.6 percent of hospitals and 17.8 percent of long-term care facilities diagnosed this bug in the first half of 2012.
  • CRE stands for “carbapenem-resistant Enterobacteriaceae.” Enterobacteriaceae are a family of more than 70 bacteria which share the characteristic of being gut-dwelling (“entero”)
  • ...3 more annotations...
  • the CDC reviewed six steps that they first published last year in a CRE Toolkit and want health care facilities to take:
  • But an important point is that none of this is required, and none of this is funded.
  • There are no reimbursements, under Medicare, for infection-control as a hospital task
  • Casey Finnerty on 07 Mar 13
     
    This article does a good job summarizing this week's announcement by the CDC director on the gravity of the CRE problem.
Casey Finnerty

Malaria and HIV Spike as Greece Cuts Healthcare Spending - Michael Scaturro - The Atlantic - 0 views

www.theatlantic.com/...275836

public health economics microbiology HIV malaria

shared by Casey Finnerty on 17 May 13 - No Cached
  • "After mosquito spraying programs were cut, we've seen a return of malaria, which the country has kept under control for the past four decades. New HIV infections have jumped more than 200 percent," he noted.
  • "Greece is an example of perhaps the worst case of austerity leading to public health disasters," Mr. Stuckler explained in a telephone interview.
  • HIV spiked because government needle exchange programs ran out of clean syringes for heroin addicts. By Stuckler's estimate, the average Greek junkie requires 200 clean needles in a given year. "But now they're only getting three a year each," Stuckler said.
Megan Rasmussen

Scientists Use Nature Against Nature to Develop an Antibiotic With Reduced Resistance - 0 views

www.sciencedaily.com/...130410201828.htm

microbiology resistance antibiotic

shared by Megan Rasmussen on 14 Apr 13 - No Cached
  • Megan Rasmussen on 14 Apr 13
     
    Researchers have applied knowledge about bacteria phages in order to develop a new antibiotic. They studied the enzyme 2-epimerase, which controls the formation Bacillus anthracis cell wall. Researchers used an inhibitory molecule that would bind to the allosteric site* site of this enzyme. They tested this antibiotic called Epimerox in mice infected with Ballcillus anthracis and found that it protected the mice from anthrax. It also showed that the bacteria did not develop a resistance to this inhibitory molecule. Although this is just a start, it could change so much in the quest for effective antibiotics!
Charles Bach

Denmark's Noma loses world restaurant crown after outbreak - 0 views

www.google.com/...M5jJwrifSt5mTGh5TuonzfEkyDoz1w

shared by Charles Bach on 30 Apr 13 - No Cached
  • Charles Bach on 30 Apr 13
     
    Good food doesn't mean good infection control!!
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