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Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
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  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Casey Finnerty

Eggs, Too, May Provoke Bacteria to Raise Heart Risk - NYTimes.com - 0 views

  • The lecithin study, published Wednesday in The New England Journal of Medicine, is part of a growing appreciation of the role the body’s bacteria play in health and disease. With heart disease, investigators have long focused on the role of diet and heart disease, but expanding the scrutiny to bacteria adds a new dimension.
  • “Heart disease perhaps involves microbes in our gut,”
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    First carnitine and meat, now lecithin and eggs! Darn it! All things in moderation, I guess.
Nellie Bogunovic

Man With Hole in Stomach Revolutionalized Medicine - 0 views

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    Pretty neat that his stomach acid acted as a natural disinfectant!
Abdirizak Abdi

Researchers Find Immunity Protein That Ramps Up Inflammation, and Agents That Can Block It - 0 views

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    Scientist have a found innate protein that increases inflammation and,agents that block it, resulting in increased in survival and improved lung function in animal models pneumonia. "The F-box protein Fbxo3, and other related proteins, represent ideal targets for treatment of acute lung injury, because it controls the innate immune response, is upstream of important inflammatory signaling pathways, and is more selective than traditional drugs that regulate protein turnover" noted Mark T Gladwin M.D., chief of the Division of Pulmonary, Allergy and Critical Care Medicine, Pitt School of Medicine.
Richard Herron

Viruses Can Have Immune System, Study Finds | Biology | Sci-News.com - 1 views

  • A new research led by Dr Kimberley Seed from the Tufts University School of Medicine provides the first evidence that bacteriophages – viruses that infect and replicate within bacteria – can acquire a wholly functional and adaptive immune system.
  • The study, published today in the journal Nature, finds that a viral predator of the cholera bacteria can steal the functional immune system of bacteria and use it against its bacterial host.
  • Developing phage therapy is particularly important because some bacteria, called superbugs, are resistant to most or all current antibiotics.
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  • This study focused on a phage that attacks Vibrio cholerae, the bacterium responsible for cholera epidemics in humans.
  • Finding a CRISPR/Cas system in a phage shows that there is gene flow between the phage and bacteria even for something as large and complex as the genes for an adaptive immune system,”
Richard Herron

Child born with HIV cured by US doctors | Society | The Guardian - 0 views

  • Doctors in the US have made medical history by effectively curing a child born with HIV, the first time such a case has been documented.
  • Dr Hannah Gay, who cared for the child at the University of Mississippi medical centre, told the Guardian the case amounted to the first "functional cure" of an HIV-infected child.
  • but it is likely that a tiny amount remains in their body.
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  • ypically, women with HIV are given antiretroviral drugs during pregnancy to minimise the amount of virus in their blood. Their newborns go on courses of drugs too, to reduce their risk of infection further. The strategy can stop around 98% of HIV transmission from mother to child.
    • Richard Herron
       
      I had no idea modern medicine was this effective against transmission from mother to child.
  • "It is far too early for anyone to try stopping effective therapy just to see if the virus comes back," she said.
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Casey Finnerty

AAP 2011: Discussing America's Anti-vaccine Movement - 0 views

  • In response to Pushpendra jain's comments... I am no longer amazed of anything in pediatrics. In 15 years of primary care suburban practice I have learned the following: I am an antibiotic nazi especially if i do not treat by telephone request, my medical expertise is compromised by my financial gains or relationships with pharmaceutical companies, my patients' parents do more "research" than I do--AKA reading a google searched internet account, I should be available at their whim and see them at a time convenient to their kid's soccer schedule as a walk-in service, and parents that think nothing of texting while driving their kids to said soccer game think that a 1 in 10,000-100,000 risk of a vaccination obviates its well documented scientific benefits. We are in a cycle where people no longer believe in science, but they'll be back when we see resurgences of diseases i haven't seen since medical school.
  • Dr. Segedy, I can assure you that your sentiments were shared by a majority of the attendees at the AAP conference. It seems as though we have gotten to a point where the element of surprise no longer exists; health care providers (for the most part) are numb to the fact that studies with ulterior motives (ie, Wakefield & vaccines/autism) and "celebrities" seem to have more of an impact on health care decisions than physicians who have dedicated their entire lives studying medicine. And when it comes to self diagnosing via Dr. Google, Offit specifically mentioned that a website like the "National Vaccine Information Center" (NCVIC.org) comes up on the first page of Google for a search for "vaccines" and yet the information on the website is extremely misleading and, in some cases, downright wrong. But that doesn't stop people from treating it as credible; after all, it's on the Internet so it must be true!
Megan Rasmussen

Bacteria help trace how alcohol binds to brain - 0 views

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    Researchers use a type of bacteria in order to study a protein that they have not been able to crystalize in the brain. This protein was thought to enable behavioral effects of alcohol and they are looking at studying where alcohol binds to this protein and the effects it has.
Abdirizak Abdi

New Insights Into Ebola Infection Pave the Way for Much-Needed Therapies - 0 views

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    Little research is available on how the Ebola virus buds from the plasma membrane of human cells, says senior study author Robert Stahelin of Indiana University School of Medicine. "By shedding light on this process, our study will help us to identify potential drug candidates that could interfere with this step in the viral life cycle.
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