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Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
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  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Casey Finnerty

Panel Recommends HPV Vaccine for Boys and Young Men - NYTimes.com - 0 views

  • HPV infection is the most common sexually transmitted disease — between 75 percent and 80 percent of females and males in the United States will be infected at some point in their lives. Most will overcome the infection with no ill effects. But in some people, infections lead to cellular changes that cause warts or cancer, including cervical, vaginal and vulvar cancers in women and anal cancers in men and women. A growing body of evidence suggests that HPV also causes throat cancers in men and women as a result of oral sex. HPV infections cause about 15,000 cancers in women and 7,000 cancers in men each year. And while cervical cancer rates have plunged over the past four decades because of widespread screening, anal cancer rates in men and women have been increasing. Head and neck cancers have also been increasing, with the share associated with HPV infection increasing rapidly — perhaps because oral sex has increased in popularity.
Jeremiah Williamson

2 dead in China from unusual bird flu strain - CNN.com - 0 views

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    The article shows a new strain of bird flu H7N9.  The virus has a hard time infecting humans, but for every one human infected there are thousands of birds infected.  This strain is less harmful than H5N1, but still one death has been reported.
Katelyn Madigan

Novel approaches needed to end growing scourge of 'superbugs' - 1 views

    • Katelyn Madigan
       
      How common are intestinal infections compared to the more well-known UTIs?
  • development of new antibiotics to treat these infections is plummeting
    • Katelyn Madigan
       
      Unable to keep up with the rapidly mutating strains?
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  • greater disinfection and less usage of invasive materials than can transmit antibiotic-resistant bacteria into the body
  • moderate the inflammatory response to infection or that limit microbial growth by blocking access to host resources without attempting to kill microbes.
    • Katelyn Madigan
       
      Are there multiple ways to provide resistance to the host cell? Would this be done only after an infection, so as to just limit the damage done?
  • If we want a long-term solution, the answer is not incremental tweaking of these policies and processes. Novel approaches, based on a reconceptualization of the nature of resistance, disease, and prevention, are needed.
    • Katelyn Madigan
       
      Well stated.
  • infect more than 2 million Americans every year and kill more than 100,000 annually,
Whitney Hopfauf

Doctors warned to be vigilant for warn new deadly virus sweeping the globe from Middle ... - 0 views

  • three confirmed infections in Britain suggests the virus can pass from person to person rather than from animal to humans
  • coronavirus, part of the same family of viruses as the common cold and the deadly outbreak of Severe Acute Respiratory Syndrome
  • 60-year-old man who had recently traveled to Pakistan and Saudi Arabia and developed a respiratory illness on January 24, 2013. Samples from the man showed he was infected with both the new virus and with H1N1
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    While the number of confirmed cases is really low, the unnerving aspect is that 8 of the 14 people infected died. 
Tiffany Arcand

Medical laboratory and biomedical science: Outbreak of hepatitis A virus infection in f... - 0 views

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    Outbreak of hepatitis A infection in Denmark, Finland, Norway, and Sweden. The exposure is taking place within the countries and may be foodborne from a persistent common source.
Jenna Veldhuizen

The use of porphyrins for eradication of Staphylococcus aureus in burn wound infections... - 0 views

  • susceptibilities of the multiple-drug resistant strain of S. aureus to deuteroporphyrin and to hemin were tested. The effect of the addition of porphyrins, separately and together, to a logarithmic culture was determined from the viable count of S. aureus over an 8 h period.
  • This work confirmed that a deuteroporphyrin-hemin complex is a potent killer of a multiple-antibiotic resistant S. aureus in culture
  • This complex was able to reduce the number of bacteria by six orders of magnitude within 8 h. By using this complex, which is light independent, we have overcome the problem of light penetration to the subeschar space.
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    Porphyrins represent a potential treatment for burn wound infections
Jenna Veldhuizen

Discovery holds potential in destroying drug-resistant bacteria - 0 views

  • Dr. Montelaro and his colleagues found that a particular sequence of amino acids on the tail end of HIV allow the virus to "punch into" and infect cells. The team manufactured a synthetic and more efficient version of this sequence -- called engineered cationic antimicrobial peptides, or "eCAPs" -- that laboratory tests have shown to rapidly destroy bacteria that are otherwise resistant to most standard antibiotics.
  • Traditional antibiotics typically work by poisoning important metabolic processes after being taken up by the target bacteria, a process that may take hours, or days, to clear a bacterial infection. In contrast, the eCAPs are specifically attracted to the surface of target bacteria where they disrupt the bacterial membrane, causing death within seconds, or minutes.
  • eCAPs work well against biofilms
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    very interesting...the same mechanism HIV uses to infect cells can be manufactured and used to destroy antibiotic-resistant bacteria
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Alison Prodzinski

Brand-New Vaccine Strategy Works Against Herpes, And Potentially HIV | Popular Science - 0 views

  • The Yale team’s “prime and pull” method is focused on exactly that. Working with mice, the researchers found a way to “prime” T cells to fight a certain kind of infection
  • through conventional vaccination that causes a system-wide immune response.
  • The “prime and pull” technique could potentially be used to combat any infectious agent that enters the body through any specific tissue--agents like the human immunodeficiency virus (HIV) that causes AIDS.
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    Manipulating T-Cells to fight certain infections, then pulling them out of the body as to not harm anything - because they can spread nasty diseases in places like the central nervous system.  They are now testing these T-cells against HIV. This could be revolutionary - in that the 'Prime and Pull' method could be used over and over without harming the person.  Just proof of how cool T-cells are!! Both useful and harmful if used inappropriately.
Katelyn Madigan

Potential novel treatment for influenza discovered: Scientists pursue new therapies as ... - 0 views

  • latest deadly strain of flu, H7N9, is spreading in China -- 82 people in China had been infected with the new strain of flu virus as of April 26, and 17 had died.
  • result of an immune reaction mediated by a protein called Toll-like receptor 4 (TLR4).
  • Currently, vaccines and antiviral medications are the two main approaches to preventing influenza
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    I thought it was interesting that antiviral medications should be administered within two days of infection in order to be effective. This really outlines the need for more effective treatments since this is a very short time frame and there is an increasing resistance to these antiviral therapies in general.
Megan Goldman

Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia ... - 0 views

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    Abstract While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined. This investigation thus used peripheral blood mononuclear cells and endometrial tissue from women with or without Chlamydia genital tract infection to better define this response.... The focus paper of me and Samantha Mishall's presentation on Tuesday April 30th.
Whitney Hopfauf

Electron-beam pasteurization of raw oysters may reduce viral food poisoning - 0 views

  • FDA already has approved the use of electron beam technology as a pathogen intervention strategy to control the naturally occurring Vibrio vulnificus bacterial pathogen in shellfish.
    • Whitney Hopfauf
       
      Good that it has already been approved by the FDA... step in the right direction
  • Praveen said she and the other researchers also chose the viral pathogens as opposed to bacterial as they were more difficult to treat and also require a host species.
  • if a serving size of 12 raw oysters were contaminated with approximately 100 hepatitis A and human noroviruses, an e-beam dose of 5 kGy (kilograys) would achieve a 91 percent reduction of hepatitis A infection risks and a 26 percent reduction of norovirus infection risks.
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    • Whitney Hopfauf
       
      Pretty significant except it still doesn't make me want to eat raw shellfish
  • how electron-beam pasteurization of raw oysters may reduce the possibility of food poisoning through virus.
  • results of this study will be published in the June
  • using a human norovirus surrogate called murine norovirus
  • uses commercial electricity
  • green technology because no chemicals are involved."
Alletia DeMartino

Pseudomonas aeruginosa Turns Protein Into a Virulence Factor in One Easy Step - 0 views

  • To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells.
  • P. aeruginosa, one of the most common causes of hospital-acquired pneumonia.
  • P. aeruginosa mostly uses this protein called elongation factor-Tu (EF-Tu) inside the cel
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  • but she and her collaborators have learned that as a virulence factor, it could represent a vulnerability for the bacterium
  • EF-Tu is presumed to be an essential protein, and it's performing these moonlighting functions as well. If we figured out how it was doing that, we could devise strategies to inhibit it," says Goldberg.
  • acquired pneumonia and is the leading cause of death among critically ill patients whose airways have been damaged by ventilation, trauma, or other infections.
  • P. aeruginosa takes
  • the protein EF-Tu, which was generally thought to exist only inside the cell, and decorates the exterior of the cell with it, but in a modified form.
  • EF-Tu is modified somehow to mimic ChoP, allowing P. aeruginosa to enjoy the benefits of ChoP.
  • , ChoP carries out a crucial step for setting up an infection for a number of different types of respiratory pathogens.
  • Using a host of techniques, including mass spectrometry, site directed mutagenesis of key residues in the protein, and genetic loss of function/gain of function studies, they found that P. aeruginosa only makes small changes to EF-Tu to get it to mimic this powerful ligand. P. aeruginosa transfers three methyl groups to a lysine on EF-Tu, giving it a structure similar to ChoP and allowing it to fit in the PAFR receptor in the way ChoP does.
  • "It allows [P. aeruginosa] to adhere to the cells and invade,"
  • "Its interaction with humans is accidental. It's an opportunist. The fact that it has this novel modification on this protein that is inherent in the bacterium that enables it to attach and persist and cause disease is exciting,"
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    Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!
Sean Hogan

Fighting disease from within the mosquito: New techniques to help halt the spread of di... - 1 views

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    Mosquitoes infected with the Wolbachia bacteria are unable to infect humans with diseases such as dengue, yellow fever, and possibly malaria. The bacteria the amount of productive eggs the mosquitoes can lay which makes passing along the bacteria difficult. To combat this the mosquitoes that are infected with the bacteria are also given a insecticide resistance gene. Because insecticide is a common preventative measure in parts of the world where the diseases are common, only those mosquitoes that are unable to spread disease would survive and pass along the bacteria.
Casey Finnerty

How Scientists Stopped Klebsiella Pneumoniae: Deadly Superbug Killed 6 At NIH Clinical ... - 1 views

  • 18 people harbored the dangerous germ, and six died of bloodstream infections from it. Another five made it through the outbreak only to die from the diseases that brought them to NIH's world-famous campus in the first place.
  • Infections at health care facilities are one of the nation's leading causes of preventable death, claiming an estimated 99,000 lives a year.
  • KPC has emerged over the past decade to become a fast-growing threat in intensive care units, spreading easily between very ill people and killing half of those it sickens.
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  • KPC was transmitted three separate times from Patient No. 1, and then spread more widely.
  • Test after test never found the bug on hospital workers' hands.
  • "There's better technology becoming available for your hospital to prevent these bacteria from spreading, and this is what you should expect from your hospital," he said.
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    I agree that it is wise to broaden the scope of infection control to custodial workers, since they would often be in contact with several of the inanimate objects in the room. This is really shown when they were unable to find the superbug on the "hospital workers' hands." Did they test everyone?
Casey Finnerty

Antiseptics Used to Prevent Health Care Infections Might Cause Them. Oops. | Wired Scie... - 0 views

  • pre-operative antiseptics have never been examined for infection risk. They were grandfathered into FDA approval because they were on the market long before the FDA began assessing such products, as a result of expert testimony that they would kill any microbes that contaminated them.  That assumption turns out to have been incorrect.
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
Katelyn Madigan

First documented case of child cured of HIV - 0 views

  • i diagnosed with HIV at birth and immediately put on antiretroviral therapy.
  • brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral load
  • d today no signs of HIV infection in the child can be detected by the most sensitive means available.
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  • physician was able to treat his leukemia with a stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease
  • achieved by antiretroviral therapy alone
Richard Herron

Child born with HIV cured by US doctors | Society | The Guardian - 0 views

  • Doctors in the US have made medical history by effectively curing a child born with HIV, the first time such a case has been documented.
  • Dr Hannah Gay, who cared for the child at the University of Mississippi medical centre, told the Guardian the case amounted to the first "functional cure" of an HIV-infected child.
  • but it is likely that a tiny amount remains in their body.
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  • ypically, women with HIV are given antiretroviral drugs during pregnancy to minimise the amount of virus in their blood. Their newborns go on courses of drugs too, to reduce their risk of infection further. The strategy can stop around 98% of HIV transmission from mother to child.
    • Richard Herron
       
      I had no idea modern medicine was this effective against transmission from mother to child.
  • "It is far too early for anyone to try stopping effective therapy just to see if the virus comes back," she said.
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