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Jenna Veldhuizen

Fighting disease from within the mosquito: New techniques to help halt the spread of di... - 0 views

  • When infected with the bacteria Wolbachia, mosquitoes are unable to spread viruses such as dengue
  • by introducing an insecticide resistance gene alongside the Wolbachia bacteria into the mosquito, that the insects pass on the disease-blocking bacteria to other mosquitoes faster
  • Our results show that Wolbachia-based strategies could hold the key to a cheap and sustainable approach to disease control
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    This in an interesting application in slowing the spread of diseases such as dengue and yellow fever, but one also has to wonder what this will do to the mosquito population as it reduces the mosquito's ability to lay viable eggs. How controlled will this application be and how often will it be utilized?
Casey Finnerty

Eggs, Too, May Provoke Bacteria to Raise Heart Risk - NYTimes.com - 0 views

  • The lecithin study, published Wednesday in The New England Journal of Medicine, is part of a growing appreciation of the role the body’s bacteria play in health and disease. With heart disease, investigators have long focused on the role of diet and heart disease, but expanding the scrutiny to bacteria adds a new dimension.
  • “Heart disease perhaps involves microbes in our gut,”
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    First carnitine and meat, now lecithin and eggs! Darn it! All things in moderation, I guess.
saraeberhardt

Donald R. Hopkins - How to Eradicate Guinea Worm Disease - NYTimes.com - 0 views

  • The strategy worked so well, Dr. Hopkins said, that Sierra Leone was smallpox-free in less than two years.
  • When programs are well run, he said, progress can be rapid; Ghana went from 501 cases to none in 18 months.
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    A positive article about the eradication of Guinea Worm Disease. Yet another source showing that vaccinations really do work. 
Sean Hogan

Fighting disease from within the mosquito: New techniques to help halt the spread of di... - 1 views

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    Mosquitoes infected with the Wolbachia bacteria are unable to infect humans with diseases such as dengue, yellow fever, and possibly malaria. The bacteria the amount of productive eggs the mosquitoes can lay which makes passing along the bacteria difficult. To combat this the mosquitoes that are infected with the bacteria are also given a insecticide resistance gene. Because insecticide is a common preventative measure in parts of the world where the diseases are common, only those mosquitoes that are unable to spread disease would survive and pass along the bacteria.
Katelyn Madigan

Viral reactivation a likely link between stress and heart disease - 1 views

    • Katelyn Madigan
       
      It is important not to exaggerate your findings, so I think it is good that they are honest with areas of the research that are still not definitive.
  • enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein
  • having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus
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  • looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs
  • EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors
  • Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.
  • viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease
Casey Finnerty

Panel Recommends HPV Vaccine for Boys and Young Men - NYTimes.com - 0 views

  • HPV infection is the most common sexually transmitted disease — between 75 percent and 80 percent of females and males in the United States will be infected at some point in their lives. Most will overcome the infection with no ill effects. But in some people, infections lead to cellular changes that cause warts or cancer, including cervical, vaginal and vulvar cancers in women and anal cancers in men and women. A growing body of evidence suggests that HPV also causes throat cancers in men and women as a result of oral sex. HPV infections cause about 15,000 cancers in women and 7,000 cancers in men each year. And while cervical cancer rates have plunged over the past four decades because of widespread screening, anal cancer rates in men and women have been increasing. Head and neck cancers have also been increasing, with the share associated with HPV infection increasing rapidly — perhaps because oral sex has increased in popularity.
Casey Finnerty

Molecule in meat may increase heart disease risk | Genes & Cells | Science News - 3 views

  • Hazen’s group also found that blood levels of TMAO and L-carnitine could predict heart disease risk, which they learned by collecting blood samples from 2,595 patients and tracking their health for three years.
    • Casey Finnerty
       
      That is a fairly large sample size and long term study.
  • Molecules proposed as biomarkers for heart disease often look promising in initial studies but fizzle out clinically. “We’ve been down this road so many times before.”
    • Casey Finnerty
       
      Very true.
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    This is an interesting story on how the microbiota of our gut may play an indirect role in cardiovascular disease.
Whitney Hopfauf

Lyme disease vaccine? Tick saliva found to protect mice from Lyme disease - 0 views

  • antibodies against a protein in the saliva of a pathogen's transmitting agent
  • has been shown to confer immunity when administered protectively as a vaccine.
  • Lyme bacterium known as
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  • Borrelia burgdorferi
  • combined with outer surface proteins of B. burgdorferi, the protection was even greater.
  • injected Salp15 into healthy mice and found that it significantly protected them from getting Lyme disease
  • . When it moves through the tick, it is coated with a tick salivary protein known as Salp15
  • Lyme vaccine on the market that utilized just the outer surface proteins of the bacteria. It was taken off the market in 2002
  • targeting the saliva -- the "vector molecule" that a microbe requires to infect a host -- may be applicable not just to Lyme disease but to other insect-borne pathogens
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    This is slightly out of date but very interesting
Casey Finnerty

A New Germ Theory - 99.02 - 0 views

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    The recent papers from the Cleveland Clinic on the role of microbiome in heart disease jogged my memory of Paul Ewald's work on this subject. In a way, he predicted the papers that appeared this week over 15 years ago. Put succinctly, "big, old, diseases are infectious." If they weren't, natural selection would have reduced their incidence. Fascinating theory, worth a read.
Alletia DeMartino

Human brain cells developed in lab, grow in mice - 0 views

  • The researchers generated and transplanted a type of human nerve-cell progenitor called the medial ganglionic eminence (MGE) cell, in experiments describe
  • The researchers generated and transplanted a type of human nerve-cell progenitor called the medial ganglionic eminence (MGE) cel
  • Kriegstein sees MGE cells as a potential treatment to better control nerve circuits that become overactive in certain neurological disorders.
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  • Kriegstein sees MGE cells as a potential treatment to better control nerve circuits that become overactive in certain neurological disorders.
  • , the human MGE-like cells survived within the rodent forebrain, integrated into the brain by forming connections with rodent nerve cells, and matured into specialized subtypes of interneurons.
  • To generate MGE cells in the lab, the researchers reliably directed the differentiation of human pluripotent stem cells -- either human embryonic stem cells or induced pluripotent stem cells derived from human skin
  • unlimited potential to become any human cell type.
  • To generate MGE cells in the lab, the researchers reliably directed the differentiation of human pluripotent stem cells -- either human embryonic stem cells or induced pluripotent stem cells derived from human skin.
  • These findings may serve as a model to study human diseases in which mature interneurons malfunction,
  • These findings may serve as a model to study human diseases in which
  • mature interneurons malfunction,
  • Nicholas utilized key growth factors and other molecules to direct the derivation and maturation of the human MGE-like interneurons
  • Nicholas utilized key growth factors and other molecules to direct the derivation and maturation of the human MGE-like interneurons. He timed the delivery of these fa
  • "The hope is that we can deliver these cells to various places within the nervous system that have been overactive and that they will functionally integrate and provide regulated inhibition," Nicholas said.
  • The researchers also plan to develop MGE cells from induced pluripotent stem cells derived from skin cells of individuals with autism, epilepsy, schizophrenia and Alzheimer's disease, in order to investigate how the development and function of interneurons might become abnormal -- creating a lab-dish model of disease.
  • One mystery and challenge to both the clinical and pre-clinical study of human MGE cells is that they develop at a slower, human pace, reflecting an "intrinsic clock." In fast-developing mice, the human MGE-like cells still took seven to nine months to form interneuron subtypes that normally are present near birth.
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    pretty interesting that there wasnt rejection from the mice immune system. very cool for furthering research 
Jenna Veldhuizen

Assembly of a protein degradation machine could lead to treatments in cancer, neurologi... - 0 views

  • Scientists believe that disruption of two key particles—and consequently a proteasome's ability to work correctly—has implications for cancers as well as various neurological degenerative diseases, such as Parkinson's and Huntington's diseases.
  • "In the assembly process there is only one tail that actually determines how the core particle and regulatory particle bind together," Roelofs said. "That's surprising because there are six tails, but only one is needed to give specificity, and the docking into the pocket is controlled by the chaperone."
  • the findings may reveal new targets for anticancer drugs
Nate Scheibe

Caltech Wins Toilet Challenge | Caltech - 0 views

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    "According to the World Health Organization, 2.5 billion people around the globe are without access to sanitary toilets, which results in the spread of deadly diseases. Every year, 1.5 million people-mostly those under the age of five-die from diarrhea."
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    This is the infrastructure side of many of the microbes (and more importantly the diseases associated with them) we learned about.
Amy Jorgenson

Coccidioidomycosis-A Fungal Disease of the Americas - 0 views

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    This paper is an overview of Coccidioidomycosis. The explains the demographics, the life cycle, history, immunology, and treatment. The hope for a vaccine is also prevalent in this paper.  The paper summarizes Coccidioidomycosis and gives quick details about it.  Excellent paper on learning about the disease without diving in too deeply.
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    This article discusses the etiology and epidemiology of coccidiodiomycosis as well as the potential for a vaccine to treat the devastating symptoms brought about by this disease.
Jeremiah Williamson

How Parkinson's disease protein acts like a virus - 0 views

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    This finding could possibly lead to new treatment remedies, slowing the onset of Parkinson's disease. Parkinson's works like the cold virus, the protein alpha synuclein breaks out of the lysosome and enters a neuron. The protein aggregates and clumps, causing cell death.
Casey Finnerty

Disappearing Seagrass Protects Against Pathogens, Even Climate Change, Scientists Find ... - 0 views

  • Seagrass meadows, among the most endangered ecosystems on Earth, play an outsize role in the health of the oceans.
  • The plants also fight disease, it turns out. A team of scientists reported on Thursday that seagrasses can purge pathogens from the ocean that threaten humans and coral reefs alike.
  • But the meadows are vanishing at a rate of a football field every 30 minutes.
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  • In one survey, they collected seawater and put it in petri dishes to see if colonies of disease-causing bacteria known as Enterococcus grew from the samples.
  • In a second search, the scientists grabbed fragments of DNA floating in seawater.
  • Water from the seagrass meadows had only half the level of this DNA, compared with water collected at other sites.
  • Reefs next to seagrass meadows, they found, were half as diseased as those without meadows.
  • Seagrass meadows can release so much oxygen that the surrounding water fizzes like champagne. That oxygen might be able to kill pathogens, Dr. Lamb realized. The plants also host fungi, which are known to producing bacteria-killing compounds.
  • Their research points to two main culprits. Eroded dirt washes into the Chesapeake, making the water cloudy. Seagrass get so little sunlight that the resulting dimming can be deadly.
  • Seagrass is also being pummeled by climate change. Warmer summer temperatures in Chesapeake Bay cause the plants to lose much of their oxygen through their leaves. With less oxygen to pump into their roots, they are poisoned by toxic sediments.
Casey Finnerty

Probiotic Logic vs. Gut Feelings - NYTimes.com - 1 views

  • Still, he added, taking them doesn’t seem harmful. “It’s a relatively low-cost treatment worth trying if you have a condition like Crohn’s disease,” he said. “But for most conditions, the potential benefit is uncertain.”
  • There is growing evidence for the role of the appendix in restoring a healthful balance of microbes in the body.
  • The challenge in taking probiotics is to get the microbes past the stomach, where most are killed by gastric acid, said Robert Dunn, a biologist at North Carolina State University. Once in the intestines, they must compete effectively with the microbes already present.
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    I always wondered how the probiotics we get from yogurt etc. were supposed to make it past the stomach. If the stomach does indeed neutralize probiotics, does eating yogurt to prevent antibiotic associated diarrhea (for instance) really help?
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
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