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Nathan Goodyear

Kent Holtorf: Long Term Weight Loss - More Than Will Power? - 0 views

  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • f greater than 10, it demonstrates there is a degree of leptin resistance contributing to an inability to lose weight
  • that it is difficult to lose weight with leptin resistance. High carbohydrate diets and in particular high-fructose corn syrup is shown to significantly increase leptin resistance and is a likely mechanism that high fructose corn syrup is associated with obesity
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  • inactive thyroid hormone called thyroxine
  • it is problem inside the cell that the inactive T4 is not converted to T3 but rather to a mirror image of T3 called reverse T3. The reverse T3 has the opposite effect of T3, blocking the effects of T3 and lowering rather than increasing metabolism.
  • Studies are showing that stress and dieting (especially yo-yo dieting) can set this hormone into action as well as chronic illness such as diabetes, chronic fatigue syndrome and fibromyalgia.
  • As soon as the body senses a reduction in calories, the production of reverse T3 is stimulated to lower metabolism
  • With chronic dieting or stress, the body often stays in this "starvation mode" with elevated levels of reverse T3 and decreased levels of T3, which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • Studies are showing that such standard testing will miss 80% of thyroid dysfunction
  • ree T3/reverse T3 ratio
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    Fantastic review by Dr. Holtorf on reverse T3, leptin, and weight loss
Nathan Goodyear

Circumventing leptin resistance for weight control - 0 views

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    how to correct leptin-resistance to improve weight loss; heavy read
Nathan Goodyear

Impaired Peripheral Conversion of Thyroxine to Trhodothyronine - Annual Review of Medic... - 0 views

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    peripheral conversion of t4 to reverse t3
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid G... - 0 views

  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
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    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
Nathan Goodyear

The Failure of Physiologic Doses of Reverse T3 to Effect Thyroid-Pituitary Function in ... - 0 views

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    reverse T3 does not block T4 to T3 converson; but occupies T3 receptors and inhibits T3 stimulating receptors
Nathan Goodyear

ScienceDirect - Journal of Psychiatric Research : Neuroendocrine effects of S-adenosyl-... - 0 views

  • Our results, at least in depressed men, seem to support the hypothesis of a stimulating effect of SAMe on the dopaminergic system
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    SAMe stimulates dopamine secretion in depressed men
Nathan Goodyear

ScienceDirect - Psychiatry Research : High reverse T3 levels in manic and unipolar depr... - 0 views

  • measurement of reverse T3 levels as a potential tool in differential diagnosis of affective disorders
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    reverse T3 tool in affective disorders
Nathan Goodyear

Reverse T3 levels in affective disorders. [Psychiatry Res. 1983] - PubMed result - 0 views

  • In the group of patients with acute major depressive disorder, however, a significant increase in reverse T3 levels and a significant decrease in T3 levels, but no significant difference in T4 or TSH levels
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    low free T3:elevated reverse T3 correlates with major depression and TSH and free T4 do not.
Nathan Goodyear

Extrathyroidal Conversion of Thyroxine to 3,3',5'-Triiodothyronine (Reverse-T3)and to 3... - 0 views

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    reverse T3 comes from peripheral conversion from free T4
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
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    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and... - 0 views

  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
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    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
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    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
Nathan Goodyear

Elsevier: Article Locator - 0 views

  • The most striking abnormality detected in 75 sick euthyroid patients was a highly significant reduction in the mean total serum-triiodothyronine (T3) levels, with most patients having total T3 levels in the hypothyroid range. The severity of the illness correlated well with the reduction in total serum-T3 levels.
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    low T3 in sick euthyroid clients; severity correlated with decreasing T3
Nathan Goodyear

Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid ... - 0 views

  • The data are consistent with the hypothesis that leptin and the pituitary–thyroid axis interact in the euthyroid state, and that hypothyroidism reversibly increases leptin concentrations
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    thyroid and leptin interact to control weight
Nathan Goodyear

Serum leptin concentrations in patients with thyroid disorders - Yoshida - 2001 - Clini... - 0 views

  • These results indicate that thyroid hormone may play an important role in the appropriate secretion of leptin in humans.
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    thyroid hormone plays role in stimulating leptin secretion
Nathan Goodyear

Diagnosis and Treatment of Hypothyroidism - 0 views

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    good overall read on hypothyroidism from Dr. Mercola
Nathan Goodyear

Low Serum Triiodothyronine (T3) and Hypothyroidism in Anorexia Nervosa -- CROXSON and I... - 0 views

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    low t3 conversion implicated in Anorexia Nervosa
Nathan Goodyear

Fortnightly review: Hypothyroidism: screening and subclinical disease -- Weetman 314 (7... - 0 views

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    TSH > 2 may not be a normal in many individuals
Nathan Goodyear

Leptin serves body as energy signal | Harvard Gazette - 0 views

  • replacing leptin to physiologically normal levels during fasting fully restored testosterone to baseline, indicating that leptin regulates the hypothalamic-pituitary- gonadal axis that controls the release of testosterone and estrogen
  • Leptin clearly has some effect on the thyroid hormone axis,
  • including thyroid-stimulating hormone and the free-circulating form of thyroid
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    Leptin regulates hypothalamic-pituitary axis; and don't forget thyroid too.
Nathan Goodyear

Study finds leptin plays a key role in women's health | Harvard Gazette - 0 views

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    Leptin improves weight and fertility in under weight women
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