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Nathan Goodyear

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3369477

breast cancer Tramete versicolor turkey tail mushrooms medicinal

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Turkey tail mushrooms show positive immune stimulant activity in battle against breast cancer.
Nathan Goodyear

Progesterone metabolites in breast cancer - 0 views

erc.endocrinology-journals.org/...717.long

progesterone metabolism metabolites breast cancer hormones progesterone metabolites

shared by Nathan Goodyear on 12 Jun 14 - No Cached
  • In breast tumor tissue and tumorigenic cell lines, 5α-reductase activity and mRNA expression are significantly higher, whereas 3α- and 20α-HSO activities and mRNA expression are significantly lower than in normal breast tissue and nontumorigenic cells
  • Studies using various breast cell lines have shown that 5αP and 3αHP have opposing actions in terms of cell proliferation and adhesion; 5αP stimulates cell proliferation (through increased mitosis and decreased apoptosis) and cell detachment, whereas 3αHP suppresses cell proliferation (through decreased mitosis and increased apoptosis) and detachment
  • the paracrine/ autocrine functions of 5αP are cancer-promoting and those of 3αHP are cancer-inhibiting
  • Nathan Goodyear on 12 Jun 14
     
    Awesome article on progesterone metabolism in breast cancer.  The author, weibe, describes 2 categories of progesterone metabolites in breast tissue: 5alpha-pregnanes and 4-pregnenes.  The author describes 3 primary enzymes that control the balance between these 2 metabolites--5alpha reductase, 3alpha-HSO, and 20alpha-HSO.  The resultant balance of 5alpha-dihydroprogesterone and 3alpha-dihydroprogesterone helps to determine the cancer potential of breast tissue.
Nathan Goodyear

Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast C... - 0 views

ar.iiarjournals.org/...1163.full

vitamin D vitamin d breast cancer

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    meta-analysis finds that vitamin D improves breast cancer survival.
Nathan Goodyear

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes - 0 views

clincancerres.aacrjournals.org/...2289.abstract

vitamin D vitamin d low prostate cancer

shared by Nathan Goodyear on 10 Jun 14 - No Cached
  • Nathan Goodyear on 10 Jun 14
     
    Not only was low vitamin D associated with increased diagnosis of prostate cancer at the time of diagnosis, but it was also associated with a higher Gleason grade and stage--aggressiveness.
Nathan Goodyear

Vitamin D and Prostate Cancer Survival in Veterans: Military Medicine: Vol 179, No 1 - 0 views

publications.amsus.org/...MILMED-D-12-00540

vitamin d vitamin D prostate cancer survival

shared by Nathan Goodyear on 10 Jun 14 - No Cached
  • Nathan Goodyear on 10 Jun 14
     
    retrospective study finds low vitamin D at the time of diagnosis and at follow up is associated with shorter survival.
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

www.ccjm.org/...195.full

AST ALT liver enzymes

shared by Nathan Goodyear on 10 Jun 14 - No Cached
  • Nathan Goodyear on 10 Jun 14
     
    Nice review of elevated liver enzymes.
Nathan Goodyear

Low free testosterone levels predict disease reclass... [BJU Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24898919

prostate cancer low Testosterone free men male hormone hormones disease

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    low free Testosterone levels, not Total, are predictors of reclassification in men with prostate cancer.
Nathan Goodyear

A Case of Colorectal Cancer during Pregnancy: A Brief Review of the Literature - 0 views

www.hindawi.com/...626393

colon cancer colorectal pregnancy hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    This case study reveals the complexity of cancer.  HRT and pregnancy have generally been shown to be protective against the incidence of colorectal cancer in women.  Yet, here colorectal cancer was diagnosed in the postpartum period.  Whether the high estrogen and progesterone during pregnancy played a role here is difficult to determine.
Nathan Goodyear

http://www.turkjcancer.org/pdf/pdf_TJC_489.pdf - 0 views

www.turkjcancer.org/...pdf_TJC_489.pdf

colon colorectal cancer ER PR estrogen receptor estrogen receptors progesterone receptor progesterone receptors

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    The relationship between ER and PR and colorectal cancer is yet to be determined.  It is not outside the realm of possibility that a standardization of ER/PR in colorectal cancer is unlikely.  Each cancer is unique.  There are probably some generalizations that can be made, but complete generalizations of ER/PR in colorectal cancer in women is unlikely.
Nathan Goodyear

Efficacy of the Progesterone Receptor Antagonist Mifepristone for Palliative Therapy of... - 0 views

ar.iiarjournals.org/...623.full

progesterone receptor progesterone receptor progesterone receptors mifepristone cancer

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Another study points to mifepristone in the benefit of progesterone receptor blockade in late stage cancer.
Nathan Goodyear

Loss of ERbeta expression as a common step in estrogen-dependent tumor progression - 0 views

erc.endocrinology-journals.org/...537.full.pdf

ER-beta ER beta estrogen cancer hormone hormones ER estrogen receptors receptor breast colon colorectal alpha ER-alpha

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    ER beta loss has been shown to contribute to tumor progression
Nathan Goodyear

Mifepristone May Halt Progression of Extensively Metastatic Human Adenocarcinoma of the... - 0 views

ar.iiarjournals.org/...1611.full

mifepristone colon colorectal cancer progesterone hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Interesting presentation of 2 case studies where by mifepristone was used in the treatment of late stage colo-rectal cancer.  The authors even propose a potential mechanism where by inhibition of progesterone signaling resulted in increased NK activity.
Nathan Goodyear

Sex Hormones and Colorectal Cancer: What Have We Learned So Far? - 0 views

jnci.oxfordjournals.org/...jnci.djq444.full

hormones colon colorectal cancer

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    This article focus' more on the risks of colorectal cancer in men.  It does perform a mini-review on risks for women.  It appears progesterone is important in prevention of colorectal cancer in women.  Post-menopause, women with HRT have a reduced risk. In contrast, men with androgen deprivation therapy, there is an increase risk of colorectal cancer.
Nathan Goodyear

Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorect... - 0 views

www.ncbi.nlm.nih.gov/...PMC3215447

estrogen progesterone ER estrogen receptor estrogen receptors ER alpha ER beta ER-alpha ER-beta PR progesterone receptor progesterone receptors

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Study finds ER and PR increase along the timeline of tumor initiation.  The authors point to likely association that ER and PR expression is associated with and key to initiating colorectal transformation.  A lot to be determined from this study.  IF this were entirely true, then what to explain the 35% lower colorectal cancer risk in women vs men?  Likely ER and PR pertubance plays a significant role is likely, but the mere expression--yet to be determined.
Nathan Goodyear

Control of Colon Cancer Development and Progression: Role of Estrogens in Colorectal Ca... - 0 views

www.medscape.com/...576817_3

colon colon cancer cancer estrogen ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Estrogens decrease colon cancer risk likely via ER beta activity.
Nathan Goodyear

Estrogen receptor acts as a dominant regulator of estrogen signaling - 0 views

www.nature.com/...1203828a.html

ER beta ER-beta ER alpha ER-alpha ER estrogen receptor estrogen receptors estrogen

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    ER-beta expression appears to regulate estrogenic activity through ER-alpha expression.  Co-expression of ER-alpha and ER-beta is associated with reduced estrogenic signaling, indicating a significant counter regulatory role for ER-beta.
Nathan Goodyear

Opposing Action of Estrogen Receptors α and β on Cyclin D1 Gene Expression - 0 views

www.jbc.org/24353

ER beta ER-beta ER estrogen receptor beta estrogen receptor estrogen receptors cancer ER-alpha ER alpha estrogen

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    ER-beta inhibits ER-alpha activation of cell proliferation via cyclin D1 gene expression.  This points to ER-beta as a counter regulatory receptor to ER-alpha.  This explains how a loss of ER-beta expression is found to be associated with increased cancers.  
Nathan Goodyear

Loss of expression of oestrogen receptor beta in c... [Oncol Rep. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15944762

ER beta ER-beta colon cancer estrogen receptor estrogen receptors estrogen receptor beta colorectal

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Loss of ER beta associated with higher risk of colon cancer.  ER beta has been shown to be highly expressed in health colons.  It has been proposed that loss of this ER beta expression is associated with carcinogenesis.
Nathan Goodyear

Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucos... - 0 views

www.ejcancer.com/...abstract

ER estrogen receptor estrogen receptors ER beta ER-beta colon colorectal cancer estrogen receptor beta women hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    ER beta expression is dominantly expressed in normal, healthy colon cells/tissue.  However, like in breast and prostate cancer, ER beta expression is lost in the dedifferentiation of colorectal transformation.
Nathan Goodyear

ERβ Has Nongenomic Action in Caveolae: Molecular Endocrinology: Vol 16, No 5 - 0 views

press.endocrine.org/...mend.16.5.0827

ER estrogen receptor estrogen receptors ER-alpha ER alpha ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Estrogen receptors are primarily located inside the nucleus and in the cytoplasm; not on the cell membrane surface. This article specifically focus' on the non-genomic action of ER-beta.  ER-alpha and ER-beta are classic transcription factors.
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