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Nathan Goodyear

Access : Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrom... - 1 views

www.nature.com/...ncpendmet0837.html

saliva salivary testing hormone evaluation diagnosis cushing's syndrome

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    late-night salivary cortisol yields sensitivity of 92-100% and specificity of 93-100%.  Wow!  not much in medicine even approaches this kind of validity.
Nathan Goodyear

The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline - 1 views

www.ncbi.nlm.nih.gov/...PMC2605410

salivary saliva cortisol testing cushing's disease syndrome

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • the diagnostic sensitivity and specificity is said to be excellent (92–100%)
  • Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States
  • Nathan Goodyear on 27 Nov 11
     
    Endocrine society clinical  practice guideline's state proves validity of salivary cortisol testing.  Statement: "the diagnostic sensitivity and specificity is said to be excellent (92-100%)" and " Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States"
Nathan Goodyear

A single sleeping midnight cortisol ha... [Clin Endocrinol (Oxf). 1995] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...8548938

salivary cortisol saliva testing evaluation sensitivity cushing's syndrome

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    salivary cortisol testing shown to be 100% sensitive for the diagnosis of Cushing's syndrome
Nathan Goodyear

Midnight Salivary Cortisol for the Initial Diagnosis of Cushing's Syndrome of Various C... - 1 views

jcem.endojournals.org/...3345

saliva salivary testing evaluation cortisol hormone hormones BHRT Cushing's syndrome

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Measuring midnight salivary cortisol is an easy and noninvasive means of diagnosing hypercortisolism
  • Its diagnostic accuracy is identical to, if not better than, that of previously described gold standards.
  • Nathan Goodyear on 28 Nov 11
     
    midnight salivary cortisol said to be diagnostically as accurate if not better than previous gold standards
Nathan Goodyear

Late-night salivary cortisol in normal subjects and in patients with Cushing's syndrome... - 1 views

pmj.bmj.com/...399.abstract

saliva salivary cortisol testing test evaluation Cushing's syndrome

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    specificity of saliva/salivary cortisol testing for Cushing's syndrome is 100%; but sensitivity was 69%.  Testing not done via LC-MS which is the gold standard.  This could explain the low sensitivity as compared to other studies.
Nathan Goodyear

ScienceDirect - Clinical Biochemistry : Advantage of salivary cortisol measurements in ... - 1 views

www.sciencedirect.com/...S000991200800043X

Saliva salivary testing test cortisol hormone hormones evaluation BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome
  • Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease
  • Nathan Goodyear on 28 Nov 11
     
    salivary cortisol is shown to be reliable for both Addison's and Cushing's Syndrome
Nathan Goodyear

Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in... - 1 views

onlinelibrary.wiley.com/...abstract

saliva salivary test testing evaluation cortisol BHRT LC-MS

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    LC-MS/MS shows excellent sensitivity and specificity for cortisol evaluation
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 1 views

www.eje-online.org/...9.short

saliva salivary testing test evaluation cortisol hormone hormones BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    salivary cortisol testing said to be "first-line" and preferable to serum cortisol evaluation
Nathan Goodyear

Utility of Salivary Cortisol Measurements in Cushing's Syndrome and Adrenal Insufficiency - 1 views

jcem.endojournals.org/...3647.abstract

saliva salivary cortisol hormone hormones test testing evaluation adrenal HPA axis BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • It is expected that the use of the measurement of salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis.
  • Nathan Goodyear on 28 Nov 11
     
    Salivary cortisol testing shown to have sensitivity and specificity that exceeds 90%.  Final Quote: "salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis
Nathan Goodyear

Clinical accuracy of midnight salivary cortisol measured by automated electrochemilumin... - 1 views

acb.rsmjournals.com/...228.abstract

saliva salivary cortisol hormone hormones BHRT cushing's syndrome

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    midnight salivary cortisol by electrochemiluminescence immunoassay shown to have sensitivity of 100% and specificity of 97.4% in Cushing's syndrome
Nathan Goodyear

AACE - Journal Article - 1 views

aace.metapress.com/...45rnu666q7530601

saliva salivary cortisol hormone hormones BHRT evaluation cushing's syndrome

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    meta-analysis reveals specificity of 96% and sensitivity of 92% for late-night cortisol diagnosis of Cushing's syndrome 
Nathan Goodyear

Late-night and low-dose dexamethasone-suppressed cortisol in saliva and serum for the d... - 1 views

www.eje.org/...747.short

saliva salivary cortisol testing test evaluation BHRT adrenal HPA axis adenoma serum diagnosis

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    diagnostic accuracy again proven for salivary cortisol. So why does BCBS consider this experimental?  Maybe they just don't read research.
Nathan Goodyear

Percutaneous administration of progesterone: blood levels an... : Menopause - 1 views

journals.lww.com/...of_progesterone__blood.19.aspx

progesterone serum testing test evaluation transdermal blood levels

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    serum evaluation of progesterone is not reliable method of testing following transdermal progesterone
Nathan Goodyear

EDTA Chelation Therapy: A Retrospective Study of 470 Patients - 1 views

www.drcranton.com/...study6.htm

EDTA chelation arteriosclerosis atherosclerosis CVA therapy

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    study of EDTA chelation in arteriosclerosis in retrospective study.
Nathan Goodyear

Hypocortisolism: An Evidence-based Review - 1 views

dl-web.dropbox.com/...3_Hypocortisolism_3%5B1%5D.pdf

adrenal fatigue hypocortisolism saliva salivary coritsol testing test hormone

shared by Nathan Goodyear on 04 Jan 12 - No Cached
  • Nathan Goodyear on 04 Jan 12
     
    Fantastic review of the literature as it relates to hypocortisolism. This paper reviews the various proposed pathophysiologic mechanisms for the development of hypocortisolism. It also discusses the proper diagnostic test of choice: salivary cortisol testing.
Nathan Goodyear

The Metabolic Syndrome - 1 views

edrv.endojournals.org/...777.full

metabolic syndrome

shared by Nathan Goodyear on 09 Jan 12 - No Cached
  • Nathan Goodyear on 09 Jan 12
     
    good review on Metabolic Syndrome
Nathan Goodyear

metabolic endotoxemia - 1 views

dl-web.dropbox.com/...metabolic%20endotoxemia.pdf

metabolic endotoxemia inflammation insulin resistance obesity overweight LPS

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    great read on the current understanding on metabolic endotoxemia.
Nathan Goodyear

Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challengi... - 1 views

www.ncbi.nlm.nih.gov/...PMC497621

EBV virus Epstein-Barr

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Everything you ever wanted to know about EBV.
Nathan Goodyear

Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Ca... - 1 views

circ.ahajournals.org/...2694.short

low T Testosterone mortality cardiovascular disease cancer men

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Low T is associated with increased risk of all cause mortality, including cardiovascular and Cancer in men.
Nathan Goodyear

Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis - 1 views

jcem.endojournals.org/...3007

low T testosterone mortality rate men

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Low T is shown to increase mortality rate, due to all causes, in men.  This was a meta-analysis of 820 studies from 1988 to 2010.
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