Dr. Goodyear

administration of a potent and selective aromatase antagonist reduces estradiol and elevates mean LH concentrations equivalently in young and older men. The low estrogen-feedback state in elderly men unmasks diminished incremental LH pulse amplitude and area; absence of further acceleration of LH pulse frequency; impaired regulation of the orderliness of LH release; and reduced testosterone to SHBG ratios

aromatase inhibition increases serum bioavailable and total testosterone levels to the youthful normal range in older men with mild hypogonadism

the congenital lack of estrogen activity seems to be associated with a slightly impaired secretion of PRL and TSH

There is substantial evidence that mitochondria are involved in the aging process

abnormal mitochondrial dynamics relevant to neuronal synaptic loss and cell death in neurodege

Taken together, these observations and our previous findings that mtDNA mutations and oxidative damage are increased in aging human tissues suggest that mitochondrial theory of aging is mature.

abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes

Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva:

The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.

It seems probable that measurement of salivary E3 could adequately replace that of plasma unconjugated E3 in the assessment of fetoplacental function.

Our work confirms the feasibility of collecting samples for salivary steroid assay in field situations