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Nathan Goodyear

Frontiers | Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies | Immunology - 0 views

www.frontiersin.org/...full

M2 macrophages radiation cancer chemotherapy M1 macrophages

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    Chemotherapy and radiation induce M2 macrophage polarization favoring metastasis.
Nathan Goodyear

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages | Journal of Experimental & Clinical Cancer Research | Full Text - 0 views

jeccr.biomedcentral.com/...s13046-018-0938-5

hydroxychloroquine M1 macrophages M2 macrophages TME tumor microenvironment cancer repurposed drugs

shared by Nathan Goodyear on 28 Nov 22 - No Cached
  • Nathan Goodyear on 28 Nov 22
     
    hydroxychloroquine induces chemo-sensitivity and pushes M2 to M1 macrophage polarization. Effects occur within the TME to increase CD8+ activity within the TME.
Nathan Goodyear

The Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion - 0 views

cancerres.aacrjournals.org/...10464.full

NF-KappaB inflammation Cancer breast Breast Cancer

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    NF-kappaB and the associated inflammatory pathways are associated with tumor growth, vascular growth within the tumor, and increased migration of macrophages--thus more inflammation.  When NF-kappaB inhibition was achieved, tumor macrophages and new tumor blood vessel growth was decreased.  Reduced blood vessel growth to the tumor has implications on metastasis of the tumor.
Nathan Goodyear

JCI - Inflammatory links between obesity and metabolic disease - 0 views

www.jci.org/57132

obesity overweight weight-loss inflammation metabolic disease

shared by Nathan Goodyear on 04 Jan 12 - No Cached
  • metainflammation
  • The chronic nature of obesity produces a tonic low-grade activation of the innate immune system that affects steady-state measures of metabolic homeostasis over time
  • It is clear that inflammation participates in the link between obesity and disease
  • ...25 more annotations...
  • Multiple inflammatory inputs contribute to metabolic dysfunction, including increases in circulating cytokines (10), decreases in protective factors (e.g., adiponectin; ref. 11), and communication between inflammatory and metabolic cells
  • adipose tissue macrophage (ATM)
  • Physiologic enhancement of the M2 pathways (e.g., eosinophil recruitment in parasitic infection) also appears to be capable of reducing metainflammation and improving insulin sensitivity (27).
  • increasing adiposity results in a shift in the inflammatory profile of ATMs as a whole from an M2 state to one in which classical M1 proinflammatory signals predominate (21–23).
  • The M2 activation state is intrinsically linked to the activity of PPARδ and PPARγ
  • well-known regulators of lipid metabolism and mitochondrial activity
  • Independent of obesity, hypothalamic inflammation can impair insulin release from β cells, impair peripheral insulin action, and potentiate hypertension (63–65).
  • inflammation in pancreatic islets can reduce insulin secretion and trigger β cell apoptosis leading to decreased islet mass, critical events in the progression to diabetes (33, 34)
  • Since an estimated excess of 20–30 million macrophages accumulate with each kilogram of excess fat in humans, one could argue that increased adipose tissue mass is de facto a state of increased inflammatory mass
  • JNK, TLR4, ER stress)
  • NAFLD is associated with an increase in M1/Th1 cytokines and quantitative increases in immune cells
  • Upon stimulation by LPS and IFN-γ, macrophages assume a classical proinflammatory activation state (M1) that generates bactericidal or Th1 responses typically associated with obesity
  • DIO, metabolites such as diacylglycerols and ceramides accumulate in the hypothalamus and induce leptin and insulin resistance in the CNS (58, 59)
  • saturated FAs, which activate neuronal JNK and NF-κB signaling pathways with direct effects on leptin and insulin signaling (60)
  • Lipid infusion and a high-fat diet (HFD) activate hypothalamic inflammatory signaling pathways, resulting in increased food intake and nutrient storage (57)
  • Maternal obesity is associated with endotoxemia and ATM accumulation that may affect the developing fetus (73)
  • Placental inflammation is a characteristic of maternal obesity
  • a risk factor for obesity in offspring, and involves inflammatory macrophage infiltration that can alter the maternal-fetal circulation (74
  • Of these PRRs, TLR4 has received the most attention, as this receptor can be activated by free FAs to generate proinflammatory signals and activate NF-κB
  • Nod-like receptor (NLR) family of PRRs
  • ceramides and sphingolipids
  • The adipokine adiponectin has long been recognized to have positive benefits on multiple cell types to promote insulin sensitivity and deactivate proinflammatory pathways.
  • adiponectin stimulates ceramidase activity and modulates the balance between ceramides and sphingosine-1-phosphate
  • Inhibition of ceramide production blocks the ability of saturated FAs to induce insulin resistance (101)
  • NF-κB, obesity also activates JNK in insulin-responsive tissues
  • Nathan Goodyear on 04 Jan 12
     
    must read to see our current knowledge on the link between inflammation and obesity.
Nathan Goodyear

A role for the body burden of aluminium in va... [Med Hypotheses. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19004564

aluminum macrophagic myofasciitis macrophagic myofasciitis chronic fatigue syndrome

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Aluminum, macrophagic myofasciitis, and chronic fatigue syndrome.
Nathan Goodyear

New Study Links Aluminum Adjuvants in Vaccines with Neurological Disorders | Health Impact News - 0 views

healthimpactnews.com/...es-with-neurological-disorders

aluminum vaccines vaccinations brain neurology inflammation Macrophagic myofasciitis Macrophagic myofasciitis

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    good review of the biochemistry of neuroinflammation and aluminum from Macrophagic myofasciitis.
Nathan Goodyear

Central nervous system disease in patients with macrop... [Brain. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11335699

aluminum macrophagic myofasciitis macrophagic myofasciitis CNS disease central nervous system brain

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Macrophagic myofasciitis and CNS disease. This study describes disease that mimics MS as a result of aluminum.
Nathan Goodyear

Long-term follow-up of cognitive dysfunction... [J Inorg Biochem. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22099155

Aluminum macrophagic myofasciitis macrophagic myofasciitis associated cognitive dysfunction MACD

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Aluminum and Macrophagic myofasciitis associated cognitive dysfunction (MACD).
Nathan Goodyear

Macrophagic myofasciitis: characterization and pathophysiology - 0 views

www.ncbi.nlm.nih.gov/...PMC3623725

Aluminum vaccines macrophage myofasciitis CNS brain neurology

shared by Nathan Goodyear on 20 Jun 13 - No Cached
  • Nathan Goodyear on 20 Jun 13
     
    Aluminum in vaccines shown to stimulate a massive autoimmune reaction.  These reactions can be localized or distant from site of injection.  Accumulation occurs in the brain and CNS.  The name give is macrophagic myofasciitis.
Nathan Goodyear

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

connection.ebscohost.com/...ione-individuals-hiv-infection

glutathione GSH Nrf2 GSSG HIV inflammation oxidative Stress

shared by Nathan Goodyear on 07 Jan 15 - No Cached
  • Nathan Goodyear on 07 Jan 15
     
    men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.
Nathan Goodyear

Glutathione supplementation improves macrophage functions in HIV. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23409922

HIV glutathione GSH NAC N-acetylcysteine macrophages

shared by Nathan Goodyear on 12 Jan 15 - No Cached
  • Nathan Goodyear on 12 Jan 15
     
    reduced glutathione, via increased oxidative stress, levels lost in HIV.  NAC and liposomal Glutathione increased innate immune function--macrophages.
Nathan Goodyear

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages: Cell - 0 views

www.cell.com/...S0092-8674(16)31162-X

inflammation LPS macrophages lipopolysaccharide mitochondria energy ATP ROS

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Fascinating study: inflammation via LPS induces pro-inflammatory move by macrophages that induces a change in mitochondria to increase inflammation and decrease ATP production.
Nathan Goodyear

Tumour-Associated Macrophages (TAMs) in Colon Cancer and How to Reeducate Them - 0 views

www.hindawi.com/...2368249

Tumor associate macrophages cancer M2 macrophages TAM M1 macrophages

shared by Nathan Goodyear on 07 Aug 19 - No Cached
  • Nathan Goodyear on 07 Aug 19
     
    Great review of TAMs and the benefit to the TME.
Nathan Goodyear

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury | Nature Immunology - 0 views

www.nature.com/...s41590-020-0764-8

macrophages immunology inflammation immune system

shared by Nathan Goodyear on 06 Apr 21 - No Cached
  • Nathan Goodyear on 06 Apr 21
     
    "The tissue niche imprints macrophage identity, phenotype and function". This quote says it all.
Nathan Goodyear

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses - 0 views

www.ncbi.nlm.nih.gov/...PMC3563931

TAMS chemotherapy Tumor associate macrophages cancer

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    Chemotherapy increases TAMs in the primary tumors. These TAMs suppresses the anti-cancer cytotoxicity of T cells. The authors here describe both TAMs and TIMs. TAMs are the M1/M2 most often discussed. M2 TAMs increase Tumor Infiltrating Macrophages (TIMs) which increase local immunosuppression and chemotherapy resistance.
Nathan Goodyear

M2 to M1; macrophage reprogramming can be done! - 0 views

acir.org/...hage-reprogramming-can-be-done

M1 macrophages M2 macrophages M1 M2

shared by Nathan Goodyear on 05 Oct 20 - No Cached
  • Nathan Goodyear on 05 Oct 20
     
    M2 to M1 polarization is possible.
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