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التغلب على مرض صمام القلب مع جراحة استبدال الصمام الهند - 0 views

arabhealthblogs.blogspot.com/...replacement-surgery-india.html جراحة استبدال الصمام الهند تكلفة جراحة استبدال الصمام الهند تكلفة جراحة استبدال الصمام في الهند جراحة استبدال الصمامات منخفضة التكلفة في الهند جراحة استبدال الصمامات بأسعار معقولة في الهند أفضل المستشفيات لاستبدال الصمامات في الهند جراحو القلب في دلهي أفض
shared by indian-health on 30 Sep 21 - No Cached
  • indian-health on 30 Sep 21
     
    أصبحت الهند الآن مركزًا للإجراءات الجراحية للقلب بتكلفة معقولة لجراحة القلب في جنوب شرق آسيا نظرًا لمستوى عالٍ من الفهم. اقرأ المزيد https://bit.ly/3zTnWtJ اتصل بنا + 91-9371136499. راسلنا على contact@indianhealthguru.com "جراحو القلب في دلهي" "أفضل جراحي القلب في دلهي" "جراحة استبدال الصمامات بالهند" "أفضل المستشفيات لاستبدال الصمامات في الهند" "تكلفة جراحة استبدال الصمامات في الهند"
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Ozone therapy: A clinical review - 0 views

www.ncbi.nlm.nih.gov/...PMC3312702 cancer Ozone
shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Its basic function is to protect humans from harmful effects of UV radiation
  • Its effects are proven, consistent and with minimal side effects
  • Medical O3, used to disinfect and treat disease, has been around for over 150 years
  • ...11 more annotations...
  • O3 not only remedied infection, but also had hemodynamic and anti-inflammatory properties
  • Stimulation of oxygen metabolism
  • In fungi, O3 inhibits cell growth at certain stages
  • With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
  • Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins
  • Activation of the immune system
  • 30 and 55 μg/cc
  • production of interferon and the greatest output of tumor necrosis factor and interleukin-2
  • Mechanism of action of O3 on the human lung
  • cascade of reactions like peroxidation of lipids leading to changes in membrane permeability,[41] lipid ozonation products (LOP) act as signal transducer molecules
  • Dietary antioxidants or free radical scavengers like vitamin E, C, etc., can prevent aforementioned effects of O3
  • Nathan Goodyear on 13 Apr 20
     
    Ozone therapy review
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Cardiac Surgery India Offers Viable Option for Heart Patients - 0 views

indianhealthguruconsultant.blogspot.com/...for-cardiac-surgery-india.html Cardiac surgery Cardiac Surgery India Heart Patients Top 10 heart surgeries hospitals of India best price for cardiac surgery India Top 10 heart surgeries hospitals heart surgeries Coronary artery disease
shared by indian-health on 06 Dec 22 - No Cached
  • indian-health on 06 Dec 22
     
    Best price for cardiac surgery India has the most minimal expense of heart surgery and is the least expensive alternative giving excellent treatment and exceedingly experienced specialists.
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Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5718030 chloroquine hydroxychloroquine cancer repurposed drugs
shared by Nathan Goodyear on 03 May 21 - No Cached
  • HCQ, doses for long-term use range between 200 and 400 mg per day.
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • ...24 more annotations...
  • bone marrow suppression
  • cardiomyopathy
  • irreversible retinal toxicity
  • hypoglycaemia
  • daily doses up to 400 mg of HCQ or 250 mg CQ for several years are considered to carry an acceptable risk for CQ-induced retinopathies, with the exception of individuals of short stature
  • chronic CQ or HCQ therapy be monitored through regular ophthalmic examinations (3–6 month intervals), full blood counts and blood glucose level checks
  • long-term HCQ exposure, skeletal muscle function and tendon reflexes should be monitored for weakness
  • both CQ and HCQ, specific caution is advised in patients suffering from impaired hepatic function (especially when associated with cirrhosis), porphyria, renal disease, epilepsy, psoriasis, glucose-6-phosphate dehydrogenase deficiency and known hypersensitivity to 4-aminoquinoline compounds
  • CQ and HCQ can effectively increase the efficacy of various anti-cancer drugs
  • CQ can prevent the entrapment of protonated chemotherapeutic drugs by buffering the extracellular tumour environment and intracellular acidic spaces
  • This study recommends an adjuvant HCQ dose of 600 mg, twice daily.
  • HCQ addition was shown to produce metabolic stress in the tumours
  • HCQ (400 mg/day)
  • important effects of CQ and HCQ on the tumour microenvironment
  • The main and most studied anti-cancer effect of CQ and HCQ is the inhibition of autophagy
  • the expression levels of TLR9 are higher in hepatocellular carcinoma, oesophageal, lung, breast, gastric and prostate cancer cells as compared with adjacent noncancerous cells, and high expression is often linked with poor prognosis
  • TLR9-mediated activation of the NF-κB signalling pathway and the associated enhanced expression of matrix metalloproteinase-2 (MMP-2), MMP-7 and cyclo-oxygenase 2 mRNA
  • HCQ can activate caspase-3 and modulate the Bcl-2/Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells
  • In triple-negative breast cancer, CQ was shown to eliminate cancer stem cells through reduction of the expression of Janus-activated kinase 2 and DNA methyl transferase 1 [106] or through induction of mitochondrial dysfunction, subsequently causing oxidative DNA damage and impaired repair of double-stranded DNA breaks
  • CQ or HCQ would be considered for use in combination with immunomodulation anti-cancer therapies
  • Therapies used in combination with CQ or HCQ include chemotherapeutic drugs, tyrosine kinase inhibitors, various monoclonal antibodies, hormone therapies and radiotherapy
  • Most studies hypothesise that CQ and HCQ could increase the efficacy of other anti-cancer drugs by blocking pro-survival autophagy.
  • daily doses between 400 and 1200 mg for HCQ are safe and well tolerated, but two studies identified 600-mg HCQ daily as the MTD
  • HCQ is often administered twice daily to limit plasma fluctuations and toxicity
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