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O2-O3 triggers tumoricidal immune response after application of a repetitive highly oxidative stimulus by insufflation of a medical O3/O2 gas mixture into the peritoneal cavity in animal model. O3/O2-PP treatment, indicates an enhanced activation of the innate and adaptive arms of the immune system, implicating a role of activated TILs In the anti cancer effects of the O3. Interestingly, COX2 expression was decreased.

To be read review of O3 in the treatment of Hodgkin's lymphoma.

Study hints at adjunctive benefit of O3 therapy with radiation therapy

Study finds that O2-O3 therapy can be useful as adjunct therapy in the treatment of Glioblastoma.