Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignan... - 0 views
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Thymidine kinase 1 (TK1) is a proliferation biomarker
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TK1 LI was found to be a more reliable prognostic marker for 5-year survival than pathological stages, FIGO stages and Ki-67,
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nuclear TK1 expression is a reliable prognostic factor in CIN patients, a group of cervical lesion patients that respond positively to treatment
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low TK1 expression in the tumors in these patients might indicate that these tumors have a lower proliferation rate
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TK1 is a key kinase in the one-step salvage pathway by which thymidine is introduced into DNA via the salvage pathway
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TK1 participates in DNA synthesis and is therefore closely related to the S-phase of the cell cycle, and is correlated with proliferation
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TK1 intensity (TK1 synthesis rate) increases from CIN grade I to CIN grade III, but does not further increase in invasive cervical carcinomas.
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TK1 intensity seems to be a prognostic factor particularly when pre-malignant cervical lesions progress to malignancy