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Low-dose methotrexate is anti-angiogenic.

Low dose cytoxan effects both local and systemic immune system.

low dose of BPA in rat model finds delayed sexual maturation.

Testosterone shown to improve GLUT 4 and IRS-1 expression with low dose short term therapy; in contrast, high dose, prolonged therapy shown to down regulate IRS-1 and GLUT 4 expression.  This shows the importance of using saliva for evaluation versus serum.  Serum testing routinely leads to over treatment with high dosages of testosterone.

Low dose ketoconazole @ 200 mg + hydrocortisone provides effects in androgen resistant prostate cancer.

This study reveals CFS to be low adrenal cortisol output problem. In this study, low dose cortisol (hydrocortisone) therapy improved symptoms of fatigue and improved the CRH adrenal stimulation of adrenal cortisol production.

low dose testosterone replacement reduces heart ischemia in those with angina, improving myocardial performance.

Master's thesis reviews Testosterone therapy in women.  The evidence is poor.  What is seen is that low SHBG and increasing Testosterone in the long term appears to be associated with adverse CV effects. Otherwise, the effects of Testosterone are negligible if negative at all.   High dose studies did find increased CVD in women. The dosing here was at 40 mg.

Study looked at aromatase activity in androgen production in older men.  The study found that aromatase inhibition with arimidex increased Testosterone production.  PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.

Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.

low dose vitamin D plus higher dose of calcium reduced stress fractures in female military recruits.

Low dose IL-2 + high dose melatonin increases 1 year survival in the treatment of solid tumors in pilot study.

Increased disease stabilization and lack of progression of solid tumor disease with low dose IL-2 and high dose melatonin.

High dose IV vitamin C effective against melanoma review finds. Low dose appears to promote melanoma.

Hermetic response: low dose suppresses growth, yet high dose propagates metastasis.

to be read

Testosterone therapy in men with low T to restore physiologic Testosterone levels found to reduce mortality, MI, and stroke risk.

Study of 209 men > 65 on Testosterone therapy was stopped early due to increase cardiovascular adverse events  The likely reason was the amazingly high dosing.  The men in this study were just doped.  The dosing was 100 mg + which is in stark contrast to the 5-10 mg daily production of a young man at 22.

DCA as proposed therapy in cancer.

synopsis of a previously posted article on LDN and OGF in the potential use in cancer.