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This study found that Huperzine A improved memory deficits in elderly and those with Alzheimer's disease.  Huperzine A is an acetylcholinisterase inhibitor, thereby increasing the neurotransmitter acetylcholine.  Huperzine A has also been shown to be neuroprotective through its antagonistic action with the NMDA receptors. Huperzine A has been shown to be protective from organophosphate toxicity.

meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.   There are a lot of animal studies that point out benefits of Huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  

Huperzine A is a great neuroprotector.  Huperzine A is a acetycholinesterase inhibitor. But, Huperzine A also reduces oxidative stress, reduces beta-Amyloid, protects mitochondria, antagonizes NMDA receptors and thus reduces excitotoxicity, and regulates apoptosis.

Huperzine A reduces EAE, an experimental MS model.  Thus, huperzine A has a anti-inflammatory effect in the brain.  

Huperzine reduces CNS iron.  This is in addition to the other neuroprotective effects of Huperzine A

small study, but well designed that showed that huperzine A supplementation improved executive function in Alzheimer's patients. huperzine A is an acetylcholinesterase inhibitor.

Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.

8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.

Huperzine A increases production of Nerve Growth Factor and Brain derived growth Factor.

Huperzine A increases hippocampal neural stem cell proliferation--neurogenesis.  This study an animal study.

Huperzine A shown to improve cognition in Alzheimer's disease.  This was a meta-analysis.

Good review of the data on Huperzine A and Alzheimer's dementia.

Huperzine A at doses up to 400 mcg shown to benefit people with Alzheimer's disease, with no significant side effects.

Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?

Huperzine A improved cognition and behavior in Alzheimer's disease

good review of treatment for Alzheimer's, both prescription and natural.

Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.

Great review of the literature supporting herbal therapies in the treatment of dementia.

I like the inclusion of western medicine and more "natural" medicine in the biochemical treatment of Alzheimer's disease. Brief review of BDNF.