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Nathan Goodyear

Therapy in the Early Stage: Incretins - 0 views

  • Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
  • in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
  • β-cell failure
    • Nathan Goodyear
       
      and studies have shown that a reduction in insulin function will decrease LH production and thus lead to a decrease in Testosterone production in men.
  • ...2 more annotations...
  • Incretins are gut-derived hormones, members of the glucagon superfamily, released in response to nutrient ingestion (mainly glucose and fat)
  • They exert a wide range of effects, including stimulation of pancreatic insulin secretion in a glucose-dependent manner and play an important role in the local gastrointestinal and whole-body physiology
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    good discussion on incretins and their role in glucose homeostasis. 
wheelchairindia9

Easy Handicap Life By Heavy Duty Wheelchair - 0 views

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    Mobility is an important part of human life. When an affordable wheelchair becomes necessary, for whatever reason, the circumstances are often not ideal. Purchasing an affordable wheelchair starts with knowing the patient and researching the types of wheelchairs available. It is a great resource on many different types of medical wheelchairs. Bariatric wheelchair, designed for users between 18 and 26 stone. It has a padded sling and backrest to ensure the comfort of the user, and the armrests can be removed to allow easy transfer into and out of the wheelchair. The Heavy User Wheelchair is self-propelled, giving the option to either push it, or have the user move themselves. The large rear wheels make the wheelchair well-suited to outdoor use, and allow the user to change the direction they face when in social situations. It has folding frame, so it is easy for storage and transport. Interchangeable frame components allow to grow and change the chairs width and depth. There are custom frame specifications available. Maximum option choices allow chair to be built to the individual's specifications. It has folding "lockout" cross-brace. Cross-brace locks to limit flex in the frame for more efficient propelling. Double cross-brace. Allows more strength and enables greater weight capacity. Wheelchair Bariatric has Adjustable back height. Ensures optimal positioning of backrest for stability and scapular movement. Stabilizer bar to minimize flex and provides a more efficient ride. Multiple footplate options ensure optimal positioning of lower extremities. Quick-release axle allows quick removal of rear wheels for easy transport. Adjustable Axle Plate Adjustments help to maximize stability and propulsion of the chair. Allows center of gravity adjustment for more efficient ride. Also makes it possible to adjust the rear frame height when it's necessary to change the caster wheels. Description: Attendant cable brake. 14" rear wheels. Detachable and washable cu
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
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    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
wheelchairindia9

Heavy Duty Wheelchair - 0 views

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    Bariatric wheelchairs (often referred to as extra wide wheelchairs or heavy duty wheelchairs) are strong enough to accommodate almost any user. Just like lighter manual chairs, bariatric wheelchairs are all foldable and feature armrests and swing-away footrests - but they differ quite a bit in their construction. While lightweight wheelchairs often employ materials like aluminum or titanium alloy, a bariatric wheelchair is usually fashioned from steel. Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Heavy duty wheelchairs (often referred to as extra wide wheelchairs or bariatric wheelchairs) are sturdy enough to accommodate almost any user. Just their lighter cousins, manual chairs, heavy duty models all fold and feature arm rests and swing-away footrests - but they differ quite a bit in their construction. Heavy duty wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Karma 8520 Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Features: Dual, reinforced steel cross braces. Supports individuals maximum weight. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support.
Nathan Goodyear

Effect of dietary GLA+/−tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts - Kenny - 2001 - International Journal of Cancer - Wiley Online Library - 0 views

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    GLA enhances the effectiveness of tamoxifen in the treatment of ER + breast cancer
Nathan Goodyear

Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions - 0 views

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    vitamin C and Zinc shown to improve immune system function and reduce the effects of the common cold and other illnesses
Nathan Goodyear

The effects of β-glucans on dendr... [Anticancer Agents Med Chem. 2013] - PubMed - NCBI - 0 views

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    Beta-glucans stimulate NK cells through TH1 stimulation.  This provides the immune enhancing effect that attacks cancer cells.
Nathan Goodyear

Orally Administered Particular β-Glucan Modulates Tumor-capturing Dendritic Cells and Improves Anti-tumor T Cell Responses in Cancer - 0 views

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    Beta glucans have both an innate and adaptive effect to enhance the environment in/and around tumor.  Beta glucans stimulate the immune system signaling to attack tumors.
Willow O'Donnell

Refurbished B. Braun Outlook 100 Infusion IV Pump - 0 views

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    Refurbished B. Braun Outlook 100 Infusion IV Pump equipped with a color-coded key pad and audible key clicks, the safe, reliable and easy to use Outlook 100 infusion pump provides comprehensive "at-a-glance" viewing of infusion status on a large color display. Designed to help prevent IV medication administration errors, the Outlook 100 Safety Infusion Pump System's extensive customizable DoseGuard™ drug library allows you to configure the pump to match your clinical practice. Hospitals confidently rely on the Outlook 100 Safety Infusion Pump System's: Real-time display of dose limit values during infusion for titration safety Active alphabetic matrix for quick and easy drug selection Proven delivery mechanism provides reliable and accurate operation Air trapping cassette eliminates nuisance alarms Enhanced battery life *Refurbished *1-Year Warranty
Willow O'Donnell

Refurbished B. Braun Outlook 100 Infusion IV Pump - 0 views

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    Refurbished B. Braun Outlook 100 Infusion IV Pump equipped with a color-coded key pad and audible key clicks, the safe, reliable and easy to use Outlook 100 infusion pump provides comprehensive "at-a-glance" viewing of infusion status on a large color display. Designed to help prevent IV medication administration errors, the Outlook 100 Safety Infusion Pump System's extensive customizable DoseGuard™ drug library allows you to configure the pump to match your clinical practice. Hospitals confidently rely on the Outlook 100 Safety Infusion Pump System's: Real-time display of dose limit values during infusion for titration safety Active alphabetic matrix for quick and easy drug selection Proven delivery mechanism provides reliable and accurate operation Air trapping cassette eliminates nuisance alarms Enhanced battery life *Refurbished *1-Year Warranty
Nathan Goodyear

Metabolic Treatment of Cancer: Intermediate Results of a Prospective Case Series - 0 views

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    advanced, end-stage cancer treated in few patients with IV alpha lipoic acid, oral LDN, and hydroxycitrate--case study presentation.  The therapies were well tolerated without toxicity.  The authors concluded that the therapy "enhances the efficacy" of the chemotherapy.
Willow O'Donnell

We buy your Refurbished LifeCare Hospira PCA 3 Infusion IV Pump - 0 views

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    Refurbished LifeCare Hospira PCA 3 Infusion IV Pump designed specifically to help prevent medication errors that commonly arise in patient-controlled analgesia, the LifeCare PCA pump features an integrated bar code reader and other features to enhance safe delivery.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease - 0 views

  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
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    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Effects of thyroid hormones on hu... [J Steroid Biochem Mol Biol. 2008] - PubMed - NCBI - 0 views

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    T3 may promote cancer cell proliferation says study.  Triiodothyronine was found to enhance the MCF-7 and T47-D breast cancer cell lines.  The conclusion of the abstract discusses a role of T3 in breast cancer development and progression.  This likely has more to do with progression than development through increased metabolism of the cell lines.
Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women | Regulatory, Integrative and Comparative Physiology - 0 views

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    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
wheelchairindia9

Easy Handicap Life By Heavy Duty Wheelchair - 0 views

  •  
    Mobility is an important part of human life. When an affordable wheelchair becomes necessary, for whatever reason, the circumstances are often not ideal. Purchasing an affordable wheelchair starts with knowing the patient and researching the types of wheelchairs available. It is a great resource on many different types of medical wheelchairs. Bariatric wheelchair, designed for users between 18 and 26 stone. It has a padded sling and backrest to ensure the comfort of the user, and the armrests can be removed to allow easy transfer into and out of the wheelchair. The Heavy User Wheelchair is self-propelled, giving the option to either push it, or have the user move themselves. The large rear wheels make the wheelchair well-suited to outdoor use, and allow the user to change the direction they face when in social situations. It has folding frame, so it is easy for storage and transport. Interchangeable frame components allow to grow and change the chairs width and depth. There are custom frame specifications available. Maximum option choices allow chair to be built to the individual's specifications. It has folding "lockout" cross-brace. Cross-brace locks to limit flex in the frame for more efficient propelling. Double cross-brace. Allows more strength and enables greater weight capacity. Wheelchair Bariatric has Adjustable back height. Ensures optimal positioning of backrest for stability and scapular movement. Stabilizer bar to minimize flex and provides a more efficient ride. Multiple footplate options ensure optimal positioning of lower extremities. Quick-release axle allows quick removal of rear wheels for easy transport. Adjustable Axle Plate Adjustments help to maximize stability and propulsion of the chair. Allows center of gravity adjustment for more efficient ride. Also makes it possible to adjust the rear frame height when it's necessary to change the caster wheels. Description: Attendant cable brake. 14" rear wheels. Detachable and washable cu
wheelchairindia9

Easy Handicap Life By Heavy Duty Wheelchair - 0 views

  •  
    Mobility is an important part of human life. When an affordable wheelchair becomes necessary, for whatever reason, the circumstances are often not ideal. Purchasing an affordable wheelchair starts with knowing the patient and researching the types of wheelchairs available. It is a great resource on many different types of medical wheelchairs. Bariatric wheelchair, designed for users between 18 and 26 stone. It has a padded sling and backrest to ensure the comfort of the user, and the armrests can be removed to allow easy transfer into and out of the wheelchair. The Heavy User Wheelchair is self-propelled, giving the option to either push it, or have the user move themselves. The large rear wheels make the wheelchair well-suited to outdoor use, and allow the user to change the direction they face when in social situations. It has folding frame, so it is easy for storage and transport. Interchangeable frame components allow to grow and change the chairs width and depth. There are custom frame specifications available. Maximum option choices allow chair to be built to the individual's specifications. It has folding "lockout" cross-brace. Cross-brace locks to limit flex in the frame for more efficient propelling. Double cross-brace. Allows more strength and enables greater weight capacity. Wheelchair Bariatric has Adjustable back height. Ensures optimal positioning of backrest for stability and scapular movement. Stabilizer bar to minimize flex and provides a more efficient ride. Multiple footplate options ensure optimal positioning of lower extremities. Quick-release axle allows quick removal of rear wheels for easy transport. Adjustable Axle Plate Adjustments help to maximize stability and propulsion of the chair. Allows center of gravity adjustment for more efficient ride. Also makes it possible to adjust the rear frame height when it's necessary to change the caster wheels. Description: Attendant cable brake. 14" rear wheels. Detachable and washable cu
wheelchairindia9

Round Ring Pillow For Bed Sores - 0 views

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    Round Ring Pillow providing effective relief to pressure sores, the rendered round ring pillow is procured from reliable source. In additions to this, the round ring pillow provides effective cushioned seating and effectively enhances the healing process. Round Ring Pillow Specifications Provideds relief to pressure sores. Provides orthopaedic cushioned seating and encourages healing. Construction with soft PVC material. Maximum weight of patient 75kgs. Round Ring Pillow Features Provides even weight bearing Renders stability while seating Easy to use
wheelchairindia9

Ergo Lite 2 - 0 views

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    Lightweight Ergonomic Wheelchair is designed to cradle patients in comfort while reducing risk of pressure sores, relieving pressure, dispersing weight evenly and improving stability. The Ergo Lite Wheelchair is easy to lift and its small size makes it ideal for travel. Weighing only 19.8 lbs., the chair is easy to store and transport. The chair folds down the middle like a standard wheelchair and the backrest also folds down to make the wheelchair even more compact. The Karman wheelchairs are exceptional in both their function and style. With comfort built right into the frame of a wheelchair eliminating the need for a "thick cushion" to add comfort, S-Shape seat allows the wheelchair to be "ergonomically correct" putting into a seating position and comfort conforming to natural body's curves. These chairs are built for comfort and quality to stand the test of time. Karma S Ergo 305 Wheelchair: The Karma S Ergo 305 Wheelchair weighs only 13 kg, has a 115 kg weight capacity and is available in 16" and 18" seat widths. With wheels and footrest removed this chair weighs 10 kg. Karma S Ergo 305 Wheelchair Features: Only 10 kg. (w/ wheels & footrests removed) Folding backrest, for transporting chair in car, bus, trips, ect. Swing in & away footrest for maximum safety while entering or exiting the chair 24" Quick Release rear spoke/polyurethane/high profile/flat free wheels & 7×1" front casters Seat Width: 18"x17" OR 16" x 17" Upholstery: Silver/Black mesh AEIGIS back and seat cushion Height Adjustable Armrest Factory Height Settings should be selected at time of purchase for convenience High strength, weighs only 13 kg. (w/o footrests) Anti-Bacterial Upholstery/Cushion Flip back armrests w/ wider contoured arm pads for maximum comfort "Tube-in Center" foot-plate, assures better side leg support Frame Color: Pearl Silver & Rose Red Axle Adjustable Seat Height ( 18", 19", 20") Weight Capacity: 115 kg. Karma KM 2512 Ergo Lite 2 Wheel
wheelchairindia9

Large Electric Scooters LY-EW415 - 0 views

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    Large Electric Scooters LY-EW415 Large Electric Scooters LY-EW415 with CTS Suspension offers a smooth ride with performance to match. Comfort-Trac Suspension (CTS) is the next generation in mobility scooter ride comfort. Large Electric Scooters LY-EW415 first technology incorporates advanced suspension components for improved absorption over rough surfaces, and a more comfortable ride experience over various terrains. Large Electric Scooters LY-EW415 Features Comfort-Trac front and rear suspension. Feather-touch disassembly permits simple frame separation with only one hand. Delta tiller with wraparound handles. Crush Proof Front Basket. Black, non-scuffing tires. Back-lit battery gauge. Full LED lighting package that includes curb and rear lights, directional signals and courtesy light under tiller. Auto connecting front to rear harness. Easy Grip Tiller adjustment knob. Easy access tiller-mounted charger port. Storage compartment below tiller. Enhanced flush-mounted horn buttons. Large Electric Scooters LY-EW415 Specifications Large medium scooter 450W motor(Optional 550W/750W)? 50AH battery Max speed: 12 km/h Max loading: 150 kg Suspension in front and rear wheels
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