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Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/1664466

rectal bioavailability 13.5%

shared by Nathan Goodyear on 15 Feb 24 - No Cached

The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/8897084

rectal bioavailability THC

shared by Nathan Goodyear on 03 Jun 21 - No Cached

Nathan Goodyear on 03 Jun 21

Rectal delivery outperforms oral

<div class="cArrow"> </div><div class="cContentInner">Rectal delivery outperforms oral</div>

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BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC3583511

supplement breast breast cancer defend'

shared by Nathan Goodyear on 26 Feb 24 - No Cached

Association of Circulating Progesterone With Breast Cancer Risk Among Postmenopausal Women - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/32329771

Progesterone breast cancer

shared by Nathan Goodyear on 26 Feb 24 - No Cached

Nathan Goodyear on 26 Feb 24

Circulating progesterone increased breast cancer risk in postmenopausal women.

<div class="cArrow"> </div><div class="cContentInner">Circulating progesterone increased breast cancer risk in postmenopausal women.</div>

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Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/29152088

ASA colorectal cancer cancer PI3K aspirin

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Aspirin and cancer: biological mechanisms and clinical outcomes - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9470249

ASA cancer aspirin

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Platelets Subvert T Cell Immunity Against Cancer via GARP-TGFβ Axis - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC5539882

tumor microenvironment ASA TGF-beta aspirin cancer TME TGF-β

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Are platelets the primary target of aspirin's remarkable anti-cancer activity? - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC6679799

cancer TME ASA tumor microenvironment platelets aspirin

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Dipyridamole prevents triple-negative breast-cancer progression - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC7654221

cancer dipyridamole

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/36939950

ASA dipyridamole aspirin cancer

shared by Nathan Goodyear on 27 Feb 24 - No Cached

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8484884

cancer Disulfiram Cu copper

shared by Nathan Goodyear on 28 Feb 24 - No Cached

The impact of PEGylation on biological therapies - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/18778113

peptides PEG polyethylene glycol

shared by Nathan Goodyear on 28 Feb 24 - No Cached

Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against Salmonella typhimurium and S. newington - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9099639

gram negative bactericidal antibiotic bacteria CBD

shared by Nathan Goodyear on 02 Mar 24 - No Cached

Fecal microbiota transplantation in metabolic syndrome: History, present and future - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC5479392

gut bacteria fecal microbiota transplant gut microbiota history fecal transplant

shared by Nathan Goodyear on 01 Mar 24 - No Cached

BRAF Modulates Lipid Use and Accumulation - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9105200

cancer lipid metabolism BRAF

shared by Nathan Goodyear on 24 Jan 24 - No Cached

Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/36132145

ivermectin metastasis cancer

shared by Nathan Goodyear on 27 Jan 24 - No Cached

Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9932048

CBD cannabidiol TBI traumatic brain injury

shared by Nathan Goodyear on 24 Jan 24 - No Cached

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC10222767

spike protein spike proteins IgG4 COVID19 COVID-19 COVID vaccination SARS-CoV-2

shared by Nathan Goodyear on 01 Jun 23 - No Cached

These mRNA vaccines represented a new type of vaccine that comprises synthetic mRNA molecules that contain the coding sequence necessary to build the SARS-CoV-2 Spike protein, which is encased in the lipid nanoparticles (LNPs) to allow for the delivery of mRNA to cells.
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proteins are synthesized within the host cells
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they can induce significant neutralizing anti-spike IgG and IgA response
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...3 more annotations...
Lethal COVID-19 cases have been linked to higher levels of IgG4 antibodies
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mRNA vaccines trigger their synthesis
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provide the scientific rationale suggesting that repeated vaccination with mRNA vaccines could generate an immune tolerance mechanism, thereby favoring unopposed SARS-CoV-2 replication.
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IgG4 Characteristics and Functions in Cancer Immunity - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC4705142

cancer immune escape IgG4

shared by Nathan Goodyear on 27 Jan 24 - No Cached

Synergistic effect of glutathione and IgG4 in immune evasion and the implication for cancer immunotherapy - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC9868885

TME IgG4 hyperprogression disease cancer tumor microenvironment glutathione

shared by Nathan Goodyear on 27 Jan 24 - No Cached

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