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in title, tags, annotations or urlThe SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling. - Abstract - Europe PMC - 0 views
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we wanted to investigate if other molecular targets and pathways may be used by SARS-CoV-2. We investigated the possibility of the spike 1 S protein and its receptor-binding domain (RBD) to target the epidermal growth factor receptor (EGFR) and its downstream signaling pathway in vitro using the lung cancer cell line (A549 cells). Protein expression and phosphorylation were examined upon cell treatment with the recombinant full spike 1 S protein or RBD. We demonstrate for the first time the activation of EGFR by the Spike 1 protein associated with the phosphorylation of the canonical Extracellular signal-regulated kinase1/2 (ERK1/2) and AKT kinases and an increase in survivin expression controlling the survival pathway.
Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach - ScienceDirect - 0 views
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Redox shift is due to Warburg effect and mitochondrial impairment.
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Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents - 0 views
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HCQ, doses for long-term use range between 200 and 400 mg per day.
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Short-term administration of CQ or HCQ rarely causes severe side effects
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Short-term administration of CQ or HCQ rarely causes severe side effects
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