Only abstract available here: compound resistance treaining in highly trained young men found to increase GH and Testosterone over isolation exercises. Those that trained > 2 years had significnt increase in Testosterone pre/post exercise compared to no statistical change in those traing < 2 years.
IV vitamin C found to significantly increased serum levels beyond that of oral. IV vitamin C is the only route that should be administered for patients with cancer. IVC at 50 grams showed peak C concentration at 13,400 micromol/L. Levels of at least 400-600 are required for tumorcidal effects. In addition, IV vitamin C increased NO release and decreases b/p
Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
non-calcified (NCP), mixed (MP), or calcified (CP) plaque
statin use was each associated with a significantly higher prevalence of NCP, MP and CP
statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
North America, Europe and Asia
A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
we identified a strong association of statin use to coronary artery plaque features
statin use was associated with a differentially increased prevalence and extent of MP and CP
one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
Coronary computed tomographic angiography (CCTA)
Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
“Intrinsic processes” include those that result in mutations due to random errors in DNA replication whereas “extrinsic factors” are environmental factors that affect mutagenesis rates (such as UV radiation, ionizing radiation, and carcinogens
intrinsic factors do not play a major causal role.
intrinsic cancer risk should be determined by the cancer incidence for those cancers with the least risk in the entire group controlling for total stem cell divisions
if one or more cancers would feature a much higher cancer incidence, for example, lung cancer among smokers vs. non-smokers, then this most likely reflects additional (and probably extrinsic) risk factors (smoking in this case)
Particularly, for breast and prostate cancers, it has long been observed that large international geographical variations exist in their incidences (5-fold for breast cancer, 25-fold for prostate cancer)14, and immigrants moving from countries with lower cancer incidence to countries with higher cancer rates soon acquire the higher risk of their new country
Colorectal cancer is another high-incidence cancer that is widely considered to be an environmental disease17, with an estimated 75% or more colorectal cancer risk attributable to diet
melanoma, its risk ascribed to sun exposure is around 65–86%
non-melanoma basal and squamous skin cancers, ~90% is attributable to UV
75% of esophageal cancer, or head and neck cancer are caused by tobacco and alcohol
HPV may cause ~90% cases in cervical cancer23, ~90% cases in anal cancer24, and ~70% in oropharyngeal cancer
HBV and HCV may account for ~80% cases of hepatocellular carcinoma
H pylori may be responsible for 65–80% of gastric cancer
While a few cancers have relatively large proportions of intrinsic mutations (>50%), the majority of cancers have large proportions of extrinsic mutations, for example, ~100% for Myeloma, Lung and Thyroid cancers and ~80–90% for Bladder, Colorectal and Uterine cancers, indicating substantial contributions of carcinogen exposures in the development of most cancers
onsistent estimate of contribution of extrinsic factors of >70–90% in most common cancer types. This concordance lends significant credibility to the overall conclusion on the role of extrinsic factors in cancer development