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Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...

PET has been in use from quite a long time, but recent years showed a great surge in the demand worldwide. Easy availability of the PET material has great emphasis on packaging due to high-quality production with reduced costs. According to a forecast from Smithers Pira, there will be a sustained annual growth of 4.6 percent year-on-year basis in next five years. Other than established economies, transitional and emerging ones become prominent players in the marketplace.

New cohort study finds increased risk of Testosterone in men > 65 and those : these are based in marketing-based medicine not evidence based medicine.

Nice review of Testosterone levels and some of the evidence linking Diabetes with low T.  However, the conclusion by the authors regarding what is causing the low T in men with Diabetes is baffling.  The literature does not point to one cause, it is clearly multifactorial--obesity, inflammation, high aromatase activity...I would suggest the authors continue their readings in the manner.

This study reveals what is wrong with a lot of the "standard practice" and literature in medicine today.  At 5 years, almost 50% of weight loss with gastric sleeve is regained--defined as excess weight loss (only 50% weight loss of excess weight).  That is a terrible 5 year outcome; not to mention the definition of success.  Even at 3 years, 31% had regained their "excess weight".  Add to that, the numbers of patients that followed up was terrible.  This poor follow up points to worse data outcomes than this study claims.

Community pharmacies played a central role in the government's response to the Covid-19 pandemic, delivering more than 22 million jabs in the past 12 months. Besides delivering millions of jabs, latest figures from NHS England and NHS Improvement (NHSE&I) revealed a 50 per cent increase in the number of pharmacies delivering Covid boosters compared from October 2021 to January 2022. NHSE&I released the data on Friday (January 14) to thank community pharmacy teams for their work during the crisis time. Lauding the efforts made by community pharmacy teams during the pandemic, Pharmaceutical Services Negotiating Committee (PSNC) director of NHS Services Alastair Buxton said: "Just over a year ago we were fighting for Government recognition of the part community pharmacy could play in administering Covid vaccines, so a year later it is great to see the efforts of the pharmacy vaccination sites being praised by NHSE&I, with recognition of the significant role they have played in the overall programme.

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This report suggests that the average clinician is practicing at a level 17 years behind the current science.  Better stated, it takes an AVERAGE of 17 years for new science to reach a clinical practice.  Scary!  Though, I am opposed to their proposed resolutions to the problem, the statistic is eye-opening.

study finds Testosterone therapy in men with low T, as defined as < 350 ng/dl and symptoms, does not increase prostate cancer sick.   Follow up was median of 5 years and maximum of 17 years.

Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.

Why has this study not received major press?  Study finds that 10+ year users of statin therapies have an 83% increased risk of invasive ductal carcinoma of the breast, a 97% increase in invasive lobular carcinoma of the breast.  In women with elevated cholesterol, the data gets worse.  There is a 204% increased risk of invasive ductal carcinoma of the breast and a 243% increased risk of invasive lobular carcinoma of the breast in women with elevated lipids and on statins 10+ years.  No matter how  you try to slice this data, this is not good news for a large sub set of women.

interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.

Testosterone levels fluctuate seasonally, with the peak production in the fall of the year.  Contrast that with LH, with it's peak in the spring of the year.  This study found that men with Klinefelter's syndrome had only seasonal fluctuations of testosterone, suggesting a testicular independent role.  This is a small study.  

Study reveals that death rate increased per year post-Bariatric surgery.  Up to 6.4% at 5 years.  This study did not follow up on additional procedures/surgeries.  The re-operation rate is 50%.

early study looking at saliva testing in infertility treatment.  This goes back almost 33 years.  But of course, it took medicine 176 years to recommend that Vitamin C help prevent scurvy on long sea journeys.

This study from 2004 reveals the marketing-based medicine era that we live in.  This meta-analysis of studies conducted for 5 year survival benefit found the contribution of chemotherapy was 2.3% in Australia and 2.1% in America.  The authors conclusion: "it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival".  Compare this to the chemotherapy harm and the balance of benefit versus harm reveals a complete lack of evidence with regards to how therapy is practiced in Cancer

Study doesn't find alot of "good" evidence to support Chinese herbal medicine in BPH.  However, the author states: "Before the introduction of conventional medication and surgery to China, the Chinese had solely relied on CHM to treat BPH for more than three thousand years".  That is 3,000 years of observational data that is being tossed out the window.

Restoration of Testosterone to normal, based on serum hypogonadism, found to significantly aid weight loss, decrease waist circumference and BMI.  This study followed men over 5 years, though by year 5 they were following roughly 50% of the original 261.

Study finds that HRT is associated with a 35% reduction in relative risk of colorectal cancer in postmenopausal women.  Even use within the previous 5 years was associated with reduced risk.  This benefit is lost at 5 years..

Observational study finds BMI increase of 0.375 in both men and women per year.  The waist circumference also increased by 0.37% per year in women compared to 0.27% in men.  There was a significant reduction in physical activity over the same time period.  In women, the reporting of physical inactivity increased to 52% FROM 19% compared to 44% FROM 11% in men.  The authors found no association with change in calories.  However, an assessment in quality of calories would have likely shown a glaring difference.  Clear causation can not be concluded due to the fact that the study was observational.