DIM's anti-estrogenic effect is found through its increased stimulation for ER beta expression. ER beta has been shown to be both anti-proliferative and anti-inflammatory.
DIM is naturally found in cruciferous vegetables
Working Women Skincare Tips If you are able to run away from fast food fast sufficient, you might be doing a enormous favour to your skin. The ingredients in fast food can damage your health and your skin too. At work, have a some of almonds, berries or some fruits handy. You need habitually eat all types and colours of organic, fresh vegetables, particularly green and leafy ones. Be necessary at least one cup of two-three dissimilar types of berries thrice a week. Take in veggie juices in your diet. These types of foods are sure to improvement your antioxidant
Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle. Translation: many don't want health even when presented with evidence of its benefits and the means to achieve it.
This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.
Study finds that 5+ daily servings of fruits/vegetables and 30 mins walking 6 days/week is associated with improved survival in women with breast cancer.
Unfortunately, on the summary is available to public, but review of nutrition for Diabetes points to Mediterranean diet, high vegetable intake, olive oil, and non-red meat intake for protein--particularily beans and legumes. Compare this to the average counseling for those with Diabetes today.
A Homeopatia é um método terapêutico baseado na prescrição de medicamentos produzidos a partir de substâncias extraídas da natureza e que podem ser de origem vegetal, mineral e animal. Cerca de 3.000 substâncias denominadas cepas, são a base dos medicamentos homeopáticos.
DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the
upper gut
Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming
capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
Main sources of soluble
DF are fruits and vegetables
n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
consumption of insoluble DF increased whole
body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible
DF polysaccharides in the colon
increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid
homeostasis
a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat
diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
malnutrition progressing to cachexia is another common manifestation of cirrhosis
Malnutrition can be mitigated with BCAA supplementation
Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
BCAAs metabolites inhibit proteolysis
Patients with cirrhosis have both insulin deficiency and insulin resistance
BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
Coadministration of BCAAs and glucose has been found to be particularly useful
BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
BCAA administration has also been shown to have a positive effect on liver regeneration
A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
patients taking BCAA supplementation report improved quality of life
BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
BCAAs make up 20-25% of the protein content of most foods
Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
In addition to BCAAs from diet, oral supplements of BCAAs can be used
Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
hyperglucagonemia results in a catabolic state eventually producing anorexia and cachexia
BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
the serum BCAA concentration is strongly correlated with the serum albumin level
Polyphenols are the most abundant antioxidants in the diet.
main dietary sources are fruits and plant-derived beverages such as fruit juices, tea, coffee, and red wine. Vegetables,
cereals, chocolate, and dry legumes also contribute to the total polyphenol intake
decreased risk of coronary heart disease with dietary
fiber consumption
Good sources of dietary fiber include
whole grains, legumes, vegetables, nuts and seeds, and fruits
most experts recommend that fiber should be obtained through the consumption of foods, because
this form allows consumption of many micronutrients and bioactive compounds contained in high-fiber foods, which provide their
own nutritional benefits.
increase in the consumption of foods containing fiber to reduce obesity, cardiovascular
disease, type 2 diabetes, and some cancers.
One of the products of fermentation, butyrate, is able to regulate
gene transcription through its actions as a histone deacetylase inhibitor, which affects cell proliferation, differentiation,
and apoptosis of colon cells