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Nathan Goodyear

Survival of cancer patients on therapy with coenzy... [Biochem Biophys Res Commun. 1993... - 0 views

www.ncbi.nlm.nih.gov/...8476426

cancer survival CoQ10

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Nathan Goodyear on 15 Feb 11
     
    CoQ10 improves cancer survival rates
Nathan Goodyear

Review: The Impacts of Circulating 25-Hydroxyvitamin D Levels on Cancer Patient Outcome... - 0 views

press.endocrine.org/...jc.2013-4320

cancer vitamin D vitamin D

shared by Nathan Goodyear on 09 Jul 14 - No Cached
  • Nathan Goodyear on 09 Jul 14
     
    meta-analysis, so take it for what it is worth; but higher vitamin D levels at the time of diagnosis were associate with better outcomes in those with cancer.  The improved outcomes included cancer mortality, disease-free survival, and overall survival.
Nathan Goodyear

PayPerView: A Randomized Study of Low-Dose Subcutaneous lnterleukin-2 Plus Melatonin ve... - 0 views

www.karger.com/...227465

IL-2 cancer melatonin colon cancer colorectal cancer

shared by Nathan Goodyear on 09 Nov 18 - No Cached
  • Nathan Goodyear on 09 Nov 18
     
    Percent survival at 1 year was significantly increased in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05) in study which suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates
Nathan Goodyear

Axillary dissection versus no axillary dissection in patients with breast cancer and se... - 0 views

www.thelancet.com/...fulltext

cancer breast cancer

shared by Nathan Goodyear on 13 Sep 18 - No Cached
  • Nathan Goodyear on 13 Sep 18
     
    study finds no disease free survival difference in those women with breast cancer and sentinel node metastasis for axillary lymph node dissection versus no disecction; no difference in overall survival at 10 years also observed.
Nathan Goodyear

The Contribution of Cytotoxic Chemotherapy to 5-year Survival in Adult Malignancies | C... - 0 views

www.scribd.com/...Survival-in-Adult-Malignancies

chemotherapy cancer

shared by Nathan Goodyear on 15 May 18 - No Cached
  • In this group, the 5-year&nbsp;survivalrateduesolelytocytotoxicchemotherapywas14%
  • There is also no convincing evidence that usingregimens with newer and more expensive drugs are anymore beneficial than the regimens used in the 1970s
  • two systematic reviews of chemotherapy inrecurrent or metastatic breast cancer have not been able toshow any survival benefit
  • ...12 more annotations...
  • The five most common adult malignancies (colorectal,&nbsp;breast, prostate, melanoma and lung cancer)
  • n breast cancer, the optimal regimen(s) for cytotoxicchemotherapy in recurrent/metastatic disease are still notdefined, despite over 30 years of ‘research’ and a plethora of&nbsp;RCTs since the original Cooper regimen was published in1969
  • The five most ‘chemo-sensitive’ cancers,namely testis, Hodgkin’s disease and non-Hodgkin’s lym-&nbsp;phoma, cervix and ovary
  • only 13 out of the 22 malignancies evaluated&nbsp;showed any improvement in 5-year survival, and theimprovement was greater than 10% in only three of those13 malignancies
  • the contribution of&nbsp;curative and adjuvant cytotoxic chemotherapy to 5-year&nbsp;survival in adults is 2.3% in Australia and 2.1% in the USA
  • a benefit of less than 2.5% is likely to&nbsp;be applicable in other developed countries
  • &nbsp; Overview The Contribution o
  • the benefit of cytotoxic chemotherapy may have&nbsp;been overestimated for cancers of oesophagus, stomach,rectum and brain.
  • this reflects the&nbsp;presentation of results as a ‘reduction in risk’ rather than asan absolute survival benefit[89,90]and by exaggerating theresponse rates by including ‘stable disease’
  • recent studies have documented impaired cognitive function inwomen receiving adjuvant treatment for breast cancer
  • the 5-year survival rate due solely to cytotoxicchemotherapy was 1.6%
  • the value of palliative chemotherapy has beenquestioned
  • Nathan Goodyear on 15 May 18
     
    Incredibly low impact of cytotoxic chemotherapy despite its wide spread utilization.  This article referenced cost yet did not evaluate the cost of cytotoxic side effect.  The question to answer: is Cytotoxic chemotherapy a valid treatment, at all, for the majority of cancers.
Nathan Goodyear

A phase II study of neuroimmunotherapy with subcutaneous low-dose IL-2 plus the pineal ... - 0 views

www.ncbi.nlm.nih.gov/...10928160

melatonin IL-2 immunotherapy cancer multiple myeloma leukemia Hodgkin's disease

shared by Nathan Goodyear on 10 May 18 - No Cached
  • Nathan Goodyear on 10 May 18
     
    Abstract only here.  Immunotherapy of IL-2 + melatonin provided lack of progression of 67% of patients included with a average duration of 21+ months in patients with untreatable advanced hematologic cancer.  Again, no toxicities.  Interesting, the survival time was similar to the previously reported survival times with the highly toxic high dose IL-2 therapy.
Nathan Goodyear

Overall survival of cancer patients with serum lactate dehydrogenase greater ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5097084

LDH lactate dehydrogenase cancer

shared by Nathan Goodyear on 08 Jun 18 - No Cached
  • catalyzes the interconversion of pyruvate and lactate during glycolysis and gluconeogenesis
  • It has long been known that many human cancers have higher LDH levels than normal tissues
  • It has long been appreciated that LDH is a prognostic factor for survival
  • ...9 more annotations...
  • The serum level of LDH correlated with tumor burden and was thought to reflect the tumor’s growth and invasive potential
  • the majority of patients with advanced or metastatic disease could be detected to have extremely high serum level of LDH
  • strong evidence to support effective chemotherapy of full dose even in patients with high LDH level
  • LDH is a key enzyme in the process of energy production in cancer cells, it catalyzes the conversion of pyruvate to lactate in hypoxic conditions
  • its function in anaerobic metabolism, cancer cells grow even after their rapid proliferation that leads to low-oxygen conditions in the tumor microenvironment
  • LDH plays an important role in tumor progression and maintenance
  • inhibition of LDH inhibits tumor progression and has been considered for the therapeutic target of cancer energy metabolism
  • LDH levels are increased in response to tissue injury or during disease states
  • LDH could be a marker of tumor burden for advanced cancer patients
  • Nathan Goodyear on 08 Jun 18
     
    High LDH, defined as >1,000, found to be maker for very poor overall survival in retrospective study.
Nathan Goodyear

Induction of Heme Oxygenase-1 and Ferritin in the Kidney in Warm Antibody Hemolytic Anemia - 0 views

www.ncbi.nlm.nih.gov/...PMC2709285

ferritin HO-1 acute kidney injury heme-oxygenate-1 AKI

shared by Nathan Goodyear on 24 May 20 - No Cached
  • Nathan Goodyear on 24 May 20
     
    induction of HO-1 induces ferritin increase to counter ROS to prolong survival. This is not a bad thing, but a survival mechanism in the short term.
Nathan Goodyear

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis - 0 views

www.neurology.org/...1004.short

ALS amyotrophic lateral sclerosis LDL:HDL cholesterol neurodegenerative disease

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Correlation studies demonstrated that bearing an abnormally elevated LDL/HDL ratio significantly increased survival by more than 12 months.
  • Nathan Goodyear on 13 Jun 12
     
    high LDL:HDL ratios in ALS patients, resulted in increased survival at 12 months.
Nathan Goodyear

Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measureme... - 0 views

www.ncbi.nlm.nih.gov/...PMC2291491

CVD PCOS women female hormone hormones CAD cardiovascular disease

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    This study looked at post menopause women and found that those with PCOS had an increase in CAD and worse cardiovascular event survival.  PCOS is a metabolic syndrome, in part, driven by elevated androgens in women.
Nathan Goodyear

Serum progesterone and prognosis in operable breast cancer. - 0 views

www.ncbi.nlm.nih.gov/...PMC2074551

progesterone breast cancer breast cancer survival

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    progesterone levels at the time of surgery predict outcome.  Higher progesterone levels associated with increased longevity.  progesterone > 4 ng/ml associated with 65% survival at 18 years versus 35% with those women and low progesterone.
Nathan Goodyear

The role of physical activity in c... [Oncology (Williston Park). 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23909073

breast cancer colon rectal colorectal exercise survival rates

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Increased survival seen in those with breast cancer that walk 3 hours weekly.  In colorectal cancer, a decrease in mortality was seen in walking 6 hours weekly.
Nathan Goodyear

Exercise improves survival rates for colorectal cancer patients - Dana-Farber Cancer In... - 0 views

www.dana-farber.org/...olorectal-cancer-patients.aspx

cancer colorectal exercise survival rates

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Men with colorectal cancer that engage in "moderate" exercise live longer than those that don't.  Moderate was described as 1 hour of walking 6 days weekly.
Nathan Goodyear

Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast C... - 0 views

ar.iiarjournals.org/...1163.full

vitamin D vitamin d breast cancer

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    meta-analysis finds that vitamin D improves breast cancer survival.
Nathan Goodyear

Low serum testosterone and increased mortality in men with coronary heart disease -- Ma... - 0 views

heart.bmj.com/...1821.abstract

low testosterone heart disease

shared by Nathan Goodyear on 21 Jan 11 - No Cached
  • n patients with coronary disease testosterone deficiency is common and impacts significantly negatively on survival
  • Nathan Goodyear on 21 Jan 11
     
    Low Testosterone decreases survival in those with heart disease
Nathan Goodyear

Vitamin supplement use during breast cancer treatment and survival: a prospective cohor... - 0 views

cebp.aacrjournals.org/...1055-9965.EPI-10-1072.abstract

breast cancer vitamin supplement

shared by Nathan Goodyear on 23 Jan 11 - No Cached
  • Nathan Goodyear on 23 Jan 11
     
    amazing study: vitamins as a part of treatment for breast cancer reduces recurrence and increases survival
Nathan Goodyear

Greater survival after breast cancer in physically active women wit... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17557947

breast cancer nutrition cancer diet exercise

shared by Nathan Goodyear on 06 Jan 15 - No Cached
  • Nathan Goodyear on 06 Jan 15
     
    Study finds that 5+ daily servings of fruits/vegetables and 30 mins walking 6 days/week is associated with improved survival in women with breast cancer.
Nathan Goodyear

PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice wit... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0065522

hyperbaric therapy hyperbaric ketogenic diet ketogenic cancer

shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • Nathan Goodyear on 12 Nov 14
     
    Hyperbaric therapy improved glucose, tumor growth rate, and increased survival time of mice from 56.7% to 77.9%.
Nathan Goodyear

Anemia as an independent prognostic factor for survival in patients with cancer - Caro ... - 0 views

onlinelibrary.wiley.com/...full

anemia cancer

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is common in cancer patients,1, 20 and it has been associated with lower survival
  • median survival was reduced by 20–43%
  • Nathan Goodyear on 30 Mar 15
     
    anemia is a poor prognostic biomarker in cancer.  But is it simply a biomarker of more advanced disease and thus merely the result of poor health?
Nathan Goodyear

Corticosteroids compromise survival in glioblastoma in part through their elevation of ... - 0 views

academic.oup.com/...2715227

glioblastoma glioblastoma multiforme "brain cancer" cancer glucose

shared by Nathan Goodyear on 23 Dec 18 - No Cached
  • Nathan Goodyear on 23 Dec 18
     
    Corticosteroids elevate glucose in patients with glioblastomas, compromising treatment and shortening survival.
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