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Nathan Goodyear

Mitochondria: a therapeutic target in neurodegener... [Biochim Biophys Acta. 2010] - Pu... - 0 views

  • mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
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    mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
Nathan Goodyear

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis - 0 views

  • Correlation studies demonstrated that bearing an abnormally elevated LDL/HDL ratio significantly increased survival by more than 12 months.
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    high LDL:HDL ratios in ALS patients, resulted in increased survival at 12 months.
Nathan Goodyear

Oxidative stress, mitochondrial dysfunction and ce... [J Neurol Sci. 2005] - PubMed result - 0 views

  • There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple sclerosis and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) associated with mitochondrial dysfunction
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    Mitochondrial dysfunction at heart of diseases such as Parkinson's, Alzheimers, MS, ALS..
Nathan Goodyear

The development of mitochondrial medicine - 0 views

  • n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and diabetes mellitus.
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    good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction
Nathan Goodyear

Vitamin E Intake and Risk of Amyotrophic Lateral Sclerosis: A Pooled Analysis of Data F... - 0 views

  • In this large, pooled prospective study, long-term vitamin E supplement use was associated with lower ALS rates
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    long-term Vitamin E intake associated with lower ALS rate
Nathan Goodyear

Vitamin E Intake and Risk of Amyotrophic Lateral Sclerosis: A Pooled Analysis of Data F... - 0 views

  • In this large, pooled prospective study, long-term vitamin E supplement use was associated with lower ALS rates
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    vitamin E reduces ALS rates
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