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Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer ... - 0 views

clincancerres.aacrjournals.org/...2580.abstract sulforaphane breast cancer broccoli
shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • sulforaphane, a natural compound derived from broccoli/broccoli sprouts
  • Sulforaphane inhibits breast CSCs
  • These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells
  • Nathan Goodyear on 18 Mar 11
     
    Sulforaphane, naturally found in broccoli  inhibits breast CSCs
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Regulation of estrogen receptor α expression in human breast cancer cells by ... - 0 views

www.jnutbio.com/...abstract sulforaphane ER alpha breast cancer cruciferous vegetables cancer estrogen
shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Sulforaphane shown to inhibit ER alpha expression in human breast cancer cell lines.  Sulforaphane is from cruciferous vegetables.
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The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arres... - 0 views

mct.aacrjournals.org/...1239.full sulforaphane cancer
shared by Nathan Goodyear on 18 Jan 13 - No Cached
  • Nathan Goodyear on 18 Jan 13
     
    Good review on the mechanism of sulforaphane in cancer treatment.
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Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role... - 0 views

www.jacionline.org/...abstract sulforaphane nrf2 Th1 Th2
shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • Nathan Goodyear on 22 Mar 11
     
    sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance
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Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotest... - 0 views

www.ncbi.nlm.nih.gov/...26923074 DHT dihdyrotestosterone sulforaphane hormones hair
shared by Nathan Goodyear on 05 Apr 16 - No Cached
  • Nathan Goodyear on 05 Apr 16
     
    sulforaphane reduces DHT through increased metabolism of DHT.
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Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts... - 0 views

www.ncbi.nlm.nih.gov/...PMC296232 sulphoraphane H. Pylori
shared by Nathan Goodyear on 24 Aug 15 - No Cached
  • Nathan Goodyear on 24 Aug 15
     
    sulforaphane proves to have activity against H. pylori.
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ScienceDirect - Clinical Immunology : Oral sulforaphane increases Phase II antioxidant ... - 0 views

www.sciencedirect.com/...S1521661608008620 sulforaphane detoxification
shared by Nathan Goodyear on 24 May 11 - No Cached
  • Nathan Goodyear on 24 May 11
     
    sulphoraphane increases Phase II detoxification
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Access : Sulforaphane Inhibits Mitotic Clonal Expansion During Adipogenesis Through Cel... - 0 views

www.nature.com/...oby2011388a.html sulphoraphane obesity overweight weight-loss PPAR-gamma C_EBP-alpha
shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    sulphoraphane shown to arrest fat cell growth.  Sulphoraphane decreased PPAR-gamma and C/EBP-alpha expression as well as suppressing the cell growth cycle.  Obvious implications in weight loss
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Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

journals.plos.org/...article Niclosamide cancer cancer stem cells breast cancer
shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
  • Nathan Goodyear on 21 Mar 18
     
    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
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