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Nathan Goodyear

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells - Clin Cancer Res - 0 views

clincancerres.aacrjournals.org/...2580.abstract

sulforaphane breast cancer broccoli

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • sulforaphane, a natural compound derived from broccoli/broccoli sprouts
  • Sulforaphane inhibits breast CSCs
  • These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells
  • Nathan Goodyear on 18 Mar 11
     
    Sulforaphane, naturally found in broccoli  inhibits breast CSCs
Nathan Goodyear

Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane - 0 views

www.jnutbio.com/...abstract

sulforaphane ER alpha breast cancer cruciferous vegetables cancer estrogen

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Sulforaphane shown to inhibit ER alpha expression in human breast cancer cell lines.  Sulforaphane is from cruciferous vegetables.
Nathan Goodyear

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice - 0 views

mct.aacrjournals.org/...1239.full

sulforaphane cancer

shared by Nathan Goodyear on 18 Jan 13 - No Cached
  • Nathan Goodyear on 18 Jan 13
     
    Good review on the mechanism of sulforaphane in cancer treatment.
Nathan Goodyear

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells - 0 views

www.jacionline.org/...abstract

sulforaphane nrf2 Th1 Th2

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • Nathan Goodyear on 22 Mar 11
     
    sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance
Nathan Goodyear

Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26923074

DHT dihdyrotestosterone sulforaphane hormones hair

shared by Nathan Goodyear on 05 Apr 16 - No Cached
  • Nathan Goodyear on 05 Apr 16
     
    sulforaphane reduces DHT through increased metabolism of DHT.
Nathan Goodyear

Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice - 0 views

www.ncbi.nlm.nih.gov/...PMC296232

sulphoraphane H. Pylori

shared by Nathan Goodyear on 24 Aug 15 - No Cached
  • Nathan Goodyear on 24 Aug 15
     
    sulforaphane proves to have activity against H. pylori.
Nathan Goodyear

ScienceDirect - Clinical Immunology : Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway - 0 views

www.sciencedirect.com/...S1521661608008620

sulforaphane detoxification

shared by Nathan Goodyear on 24 May 11 - No Cached
  • Nathan Goodyear on 24 May 11
     
    sulphoraphane increases Phase II detoxification
Nathan Goodyear

Access : Sulforaphane Inhibits Mitotic Clonal Expansion During Adipogenesis Through Cell Cycle Arrest : Obesity - 0 views

www.nature.com/...oby2011388a.html

sulphoraphane obesity overweight weight-loss PPAR-gamma C_EBP-alpha

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    sulphoraphane shown to arrest fat cell growth.  Sulphoraphane decreased PPAR-gamma and C/EBP-alpha expression as well as suppressing the cell growth cycle.  Obvious implications in weight loss
Nathan Goodyear

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

journals.plos.org/...article

Niclosamide cancer cancer stem cells breast cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
  • Nathan Goodyear on 21 Mar 18
     
    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
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