Pesticides disrupt the testicular function, in part, through oxidative damage. This study found Alpha lipoic acid to be a promising, effective mechanism to reduce the oxidative stress. They also found tocopherols to be effect, but to a lesser extent.
Many pesticides function as androgen receptor antagonists. Others as Xenoestrogens. Estrogen-like toxins and androgen receptor antagonists...a potent cocktail to disrupt male androgen signaling.
Hard to show causation here, but volume of environmental toxicants associated with shortening of Telomeres. Mechanism? Increased free radical induced mitochondrial disruption resulting in relocation of the Telomerase enzyme from the mitochondria to the nuclei. This has been shown to occur in cancer pathogenesis.
These results suggest that self-reported neurologic symptoms are associated with cumulative exposure to moderate levels of fumigants and organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning.
low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls. In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.
children that eat organic have 6 times lower levels of organophosphate (pesticide) metabolites excreted on testing compared children eating non-organic diet