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Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-... - 0 views

ar.iiarjournals.org/...1867.full dihydroartimisinin vitamin C artemisinin DHA vitamin D cancer
shared by Nathan Goodyear on 13 Jun 19 - No Cached
  • Nathan Goodyear on 13 Jun 19
     
    Vitamin C, Vitamin D found to augment DHA cancer cytotoxicity effects.
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Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-... - 0 views

ar.iiarjournals.org/...1867.long one Ethan artemisinin H2O2 vitamin D DEXA Cancer vitamin C
shared by Nathan Goodyear on 25 May 19 - No Cached
  • Nathan Goodyear on 25 May 19
     
    Study finds that vitamin C, D, H2O2, and dexamethasone combine with artemisinin to increase cell death in human leukemia cell lines.
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Immunotherapy of C3H/HeJ mammary adenocarcinoma with interleukin-2, mistletoe lectin or... - 0 views

www.sciencedirect.com/...S0959804901001563 immunotherapy IL-2 mistletoe cancer
shared by Nathan Goodyear on 01 Jun 19 - No Cached
  • Nathan Goodyear on 01 Jun 19
     
    Study finds IL-2 reduces cancer proliferation and metastasis; however, mistletoe alone found to stimulate proliferation, though at very low doses i.e. 1 ng/kg, in mouse model.
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Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylg... - 0 views

pubmed.ncbi.nlm.nih.gov/19337914 nitric oxide colon cancer NO metastasis COX2 matrix metalloproteinase hyperthermia NF-KappaB heat shock proteins MMP HSP HSP70
shared by Nathan Goodyear on 25 Feb 21 - No Cached
  • Nathan Goodyear on 25 Feb 21
     
    Hyperthermia via HSP70 blocks NF-kappaB and all associated downstream signaling that favor metastasis.
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The Effect of High Dose IV Vitamin C on Plasma Antioxidant Capacity and Level of Oxidat... - 1 views

orthomolecular.org/...2007-v22n03-p153.pdf IV vitamin C vitamin C IV vitamin C antioxidant
shared by Nathan Goodyear on 05 Jun 13 - No Cached
  • Nathan Goodyear on 05 Jun 13
     
    Studies have debated on the proxidant/antioxidant effect of high dose IV vitamin C. This study finds only antioxidant effects from IV vitamin C in vivo. This study also found the antioxidant effect plateaued out at 25 grams.
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Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164 sepsis IV vitamin C vitamin C CRP
shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
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  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
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Anti-angiogenic effect of high doses of ascorbic acid - 0 views

www.ncbi.nlm.nih.gov/...PMC2562367 vitamin C angiogenesis nitric oxide NO
shared by Nathan Goodyear on 26 Aug 20 - No Cached
  • Nathan Goodyear on 26 Aug 20
     
    Vitamin C inhibits angiogenesis via suppression of NO levels.
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Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury - S... - 0 views

www.sciencedirect.com/...S0306452202002439 ROS ferritin HO-1 heme-oxygenase-1
shared by Nathan Goodyear on 24 May 20 - No Cached
  • Nathan Goodyear on 24 May 20
     
    HO-1 induces increase in ferritin to reduce ROS
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L-ascorbate Attenuates Methamphetamine Neurotoxicity Through Enhancing the Induction of... - 0 views

pubmed.ncbi.nlm.nih.gov/23022510 heme-oxygenase-1 vitamin C oxidative stress ROS reactive oxygen species
shared by Nathan Goodyear on 24 May 20 - No Cached
  • Nathan Goodyear on 24 May 20
     
    vitamin C reduces methamphetamine induced ROS view upregulation of heme-oxygenase-1 expression.
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Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevat... - 0 views

www.ncbi.nlm.nih.gov/...PMC7284353 pneumonia vitamin C
shared by Nathan Goodyear on 17 Aug 20 - No Cached
  • Nathan Goodyear on 17 Aug 20
     
    Patients with CAP found to be depleted of vitamin C...a metabolic scurvy if you will.
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Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activ... - 0 views

www.ncbi.nlm.nih.gov/...PMC7826722 TLR4 inflammation LPS metabolic endotoxemia plant-based nutrition plant-based diet plant-based
shared by Nathan Goodyear on 03 Sep 21 - No Cached
  • consumption of this particular diet for at least a 2-month period helped to reduce the outcomes of both acute and chronic inflammation induced by LPS.
  • chronic inflammation compromised both glucose and insulin tolerance, which is normally seen in certain chronic metabolic diseases
  • LPS resulted in an increase in neopterin levels, which is a marker for immune system activation
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  • diet enriched in fruits and vegetables (and consequently phytochemicals) was able to reverse the process and maintain and even elevate insulin sensitivity and glucose tolerance
  • LPS-mediated effects are related to an increase in TLR4 levels that triggers the activation of nuclear factor-kB (NF-kB), a transcription factor that activates a cascade of inflammatory mediators [41]. These factors control the transcription of inflammatory mediators, such as IL-1β, IL-6, TNF-α, TNF-β, INF-α, INFβ, INF-γ
  • Inflammation can alter insulin action and give rise to diabetes and obesity by blocking insulin receptor downstream events, impairing insulin receptor substrate 1 (IRS-1) activation and phosphatidylinositol 3-kinase-dependent (PI3K) pathways, therefore compromising insulin signaling
  • systemic inflammation (generated by LPS) also increased neopterin levels in the urine and resulted in altered neuronal activity by decreasing dopamine (DA) metabolism
  • an increase in neopterin levels has been recognized a sensitive biomarker for immune system activation
  • Our experiments denoted that these diets were able to diminish inflammatory mediators and oxidative damage
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Ozone therapy: A clinical review - 0 views

www.ncbi.nlm.nih.gov/...PMC3312702 cancer Ozone
shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Its basic function is to protect humans from harmful effects of UV radiation
  • Its effects are proven, consistent and with minimal side effects
  • Medical O3, used to disinfect and treat disease, has been around for over 150 years
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  • O3 not only remedied infection, but also had hemodynamic and anti-inflammatory properties
  • Stimulation of oxygen metabolism
  • In fungi, O3 inhibits cell growth at certain stages
  • With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
  • Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins
  • Activation of the immune system
  • 30 and 55 μg/cc
  • production of interferon and the greatest output of tumor necrosis factor and interleukin-2
  • Mechanism of action of O3 on the human lung
  • cascade of reactions like peroxidation of lipids leading to changes in membrane permeability,[41] lipid ozonation products (LOP) act as signal transducer molecules
  • Dietary antioxidants or free radical scavengers like vitamin E, C, etc., can prevent aforementioned effects of O3
  • Nathan Goodyear on 13 Apr 20
     
    Ozone therapy review
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