Skip to main content

Home/ Dr. Goodyear/ Group items tagged z

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras | Nature Communi... - 0 views

www.nature.com/...s41467-017-01019-z

cancer glucose sugar nutrition genetics vitamin C RAS

shared by Nathan Goodyear on 20 Oct 17 - No Cached
  • glucose deprivation triggers apoptosis47 and vitamin C treatment kills RAS-oncogene expressing tumor cells, but not wild-type RAS containing cells, by inhibition of GAPDH
  • Nathan Goodyear on 20 Oct 17
     
    New study out of the UK supports the role of glucose in cancer growth and aggressiveness.  This research found that high influx of glucose into the glycolysis pathway upregulated the RAS oncogene via accumulation of the Fructose 1,6 bisphosphonate through the enzyme phosphofructokinase..
Nathan Goodyear

Is late-night salivary cortisol a better screening... [N Z Med J. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22522271

cortisol saliva urine obese

shared by Nathan Goodyear on 22 Jun 12 - No Cached
  • Nathan Goodyear on 22 Jun 12
     
    this study of 40 obese patients found saliva cortisol testing less specific than urinary; but more than Dexamethasone suppression test.  The problem with this is several fold: first, this is done via ELIZA and not Mass Spec and second, 24 hour urine collection is hard to achieve in real life.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Dr. Jennifer Martinick

Dr Jennifer Martinick: A Review Of The Surgical Hair Restoration Solutions Provided - 0 views

www.zimbio.com/...Martinick+Review+Surgical+Hair

Dr Jennifer Martinick Hair reviews

shared by Dr. Jennifer Martinick on 07 Nov 13 - No Cached
  • Dr. Jennifer Martinick on 07 Nov 13
     
    Dr Jennifer Martinick shares her reviews on Surgical Hair Restoration Solutions Provided.
Nathan Goodyear

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with meta... - 0 views

bmccancer.biomedcentral.com/...s12885-019-5696-z

IV vitamin C cancer vitamin C

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Phase I study of vitamin C and FOLFOX or FOLFIRI. Numerous studies have shown the extremely high safety profile of IV vitamin C in cancer. The need to show the same thing time and time again borders on the insanity. The potential adverse events listed in this study is from the FOLFOX or FOLFIRI, not the vitamin C.
Nathan Goodyear

Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic pat... - 0 views

bmccardiovascdisord.biomedcentral.com/...s12872-017-0560-z

cancer red yeast rice simvastatin

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Nathan Goodyear on 01 Sep 23
     
    Less side effects with red yeast rice.
1 - 17 of 17
Showing 20▼ items per page