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Nathan Goodyear

Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Respo... - 0 views

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    DHA shown to protect against post stroke inflammation and injury.  This has implications on any head injury.
Nathan Goodyear

Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum ... - 0 views

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    EPA and DHA have differing effects in men with Hyperlipidemia.  DHA increased LDL particle size, increased fasting insulin, but did not increase fasting glucose.
Nathan Goodyear

Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and... - 0 views

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    Only DHA, not EPA, reduced blood pressure and heart rate.
Nathan Goodyear

Adiponectin translation is increased by the PPARγ agonists pioglitazone and ω... - 0 views

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    Omeg-3, DHA and EPA, increased adiponectin production.  In addition, blockade of the PPAR-gamma resulted in a reduction in adiponectin production.  Thus PPAR gamma activation results in adiponectin production by adipocytes.
Nathan Goodyear

Prophylactic and therapeutic effects of n-3 polyunsaturated fatty acids, capsaicin, and... - 0 views

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    Rat study, but it finds that n-3, capsaicin, and curcumin can not only decrease the inflammation associatied with arthritis, but it can delay it all together.
Nathan Goodyear

ω-3 Fatty Acid Supplementation as a Potential Therapeutic Aid for the Recover... - 0 views

  • There is a growing body of preclinical literature suggesting that ω-3 FAs, and DHA in particular, may play a therapeutic role in mTBI
  • the potential for ameliorating or possibly even preventing the complications associated with concussions
  • DHA is the predominant ω-3 FA present in the brain, and, consistent with this finding, DHA, and not EPA, has been demonstrated to be critical for brain development and cognitive function throughout life
  • ...7 more annotations...
  • the concentration of EPA in the brain is negligible (77–80), suggesting that EPA plays a limited role in mediating the beneficial effects of LCPUFA supplementation on mTBI pathology
  • the current state of the science regarding LCPUFA supplementation for the treatment of concussion is based primarily on animal models
  • there is evidence that the amount of DHA in brain tissue is decreased after mTBI (65, 66), suggesting an elevated need for DHA in mTBI recovery.
  • the well-established role of DHA in supporting the structure and function of the brain throughout the lifespan (26, 27, 46, 47, 53) provides encouragement that LCPUFAs may also prove beneficial in the context of concussion recovery.
  • no therapies are currently available to aid the recovery from this injury
  • Previously discussed reports outlining the use of ω-3 FAs in the recovery from severe TBIs (reviewed in Ref. 92) described the use of very-high doses of LCPUFAs (16.2 g/d EPA plus DHA) in the recovery of these patients
  • Within the context of mTBIs/concussions, translating a DHA intake used in several rat studies of mTBI recovery (40 mg ⋅ kg−1 ⋅ d−1 DHA) (57, 63, 64) using body surface area conversion methods (93) amounts to an estimated human intake of 387 mg/d DHA
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    nice review of the evidence of n-3, particularily DHA, in concussions and concussion recovery.
Nathan Goodyear

Dietary Supplementation With the Omega-3 Fatty Acid Docosahe... : Neurosurgery - 0 views

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    Animal study finds pre-emptive DHA at 40 mg/kg reduced injury response during medically induced TBI.  Not only can DHA be used with TBI, but this study suggests it can be used in a prevention mode.
Nathan Goodyear

Higher plasma docosahexaenoic acid is associated with reduced progression of coronary a... - 0 views

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    women with higher DHA had significantly lower progression of atherosclerosis and fewer new lesions of atherosclerosis
Nathan Goodyear

ScienceDirect - Free Radical Biology and Medicine : Effect of eicosapentaenoic acid and... - 0 views

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    DHA >EPA in reducing oxidative stress in those with high blood pressure and diabetes; though both effective
Nathan Goodyear

Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment... - 0 views

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    DHA supplementation in mother increased DHA phosopholipid levels in infant; though no change in neurodevelopment was noted
Nathan Goodyear

Relationships between serum free ... [J Child Psychol Psychiatry. 1996] - PubMed - NCBI - 0 views

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    free fatty acids and zinc shown to improve symptoms of ADHD in children after testing confirmed deficiencies.
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