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Jadibuti jadibuti.net

Shatavari - 0 views

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Shatavari Asparagus racemosus

shared by Jadibuti jadibuti.net on 29 May 16 - No Cached
  • Jadibuti jadibuti.net on 29 May 16
     
    Shatavari is recommended in Ayurvedic texts for the prevention and treatment of gastric ulcers, dyspepsia and as a galactogogue. Shatavari, Asparagus racemosus, is a climbing plant which grows in low jungles areas throughout India. This sweet ...
  • Jadibuti jadibuti.net on 29 May 16
     
    Shatavari is recommended in Ayurvedic texts for the prevention and treatment of gastric ulcers, dyspepsia and as a galactogogue. Shatavari, Asparagus racemosus, is a climbing plant which grows in low jungles areas throughout India. This sweet ...
Jadibuti jadibuti.net

Bhumi Amla - 0 views

jadibuti.net/bhumi-amla

Bhumi Amla Phyllanthus Niruri

shared by Jadibuti jadibuti.net on 29 May 16 - No Cached
  • Jadibuti jadibuti.net on 29 May 16
     
    Phyllanthus niruri, also known as Bhumi Amla. Phyllanthus niruri is an annual herbaceous plant which grows to life in the terrain regions of Jharkhand Chhattisgarh, Bihar and other states of India. It is common to the rainy forests of the ...
  • Jadibuti jadibuti.net on 29 May 16
     
    Phyllanthus niruri, also known as Bhumi Amla. Phyllanthus niruri is an annual herbaceous plant which grows to life in the terrain regions of Jharkhand Chhattisgarh, Bihar and other states of India. It is common to the rainy forests of the ...
Nathan Goodyear

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Tr... - 0 views

ajp.amjpathol.org/...fulltext

Lyme Lyme disease borrelia burgdorferi

shared by Nathan Goodyear on 14 Dec 17 - No Cached
  • In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
  • Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
  • in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
  • ...41 more annotations...
  • colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
  • The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
  • The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
  • In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
  • Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
  • We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
  • The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
  • The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
  • Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
  • we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
  • Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
  • In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
  • This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
  • The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
  • Lyme, Connecticut.
  • Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
  • approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
  • Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
  • ‘post-treatment Lyme disease syndrome’ (PTLDS)
  • host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
  • inflammatory responses to residual antigens from dead organisms
  • residual tissue damage following pathogen clearance;
  • autoimmune responses, possibly elicited by antigenic mimicry
  • Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
  • Ten male rhesus macaques
  • half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
  • Minimal and focal lymphoplasmacytic inflammation
  • inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
  • Minimal localized lymphoplasmacytic choroiditis
  • Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
  • Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
  • For all animals, inflammation was reserved to perineural tissue
  • The treatment lasted 28 days
  • Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
  • A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
  • mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
  • three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
  • 10% to -20% of human patients treated
  • Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
  • and the rapid clearance of dead spirochetes in a murine model
  • higher doses may be needed to combat neuroborreliosis
  • Nathan Goodyear on 14 Dec 17
     
    persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
market reports

North America Injectable Drug Delivery Market - 0 views

www.marketsandmarkets.com/...drug-delivery-market-1109.html

North America Injectable Drug Delivery Market

shared by market reports on 14 May 13 - No Cached
  • market reports on 14 May 13
     
    North American injectable drug delivery technologies market was valued at $9.3 billion in 2012 and is estimated to grow at a CAGR of 12.3% from 2012 to 2017 to reach $16.6 billion by 2017
market reports

China consumed around 34.8% of the global n-butanol demand in 2012. - 0 views

www.facebook.com/photo.php

market research reports company

shared by market reports on 29 Apr 13 - No Cached
  • market reports on 29 Apr 13
     
    N-butanol market is witnessing an increase in demand on account of growing butyl acrylate industry, which is a major consumer of n-butanol.
Nathan Goodyear

The 20-Year Public Health Impact and Direct Cost of Testosterone Deficiency in U.S. Men... - 0 views

onlinelibrary.wiley.com/...48D8B444401449DB28B6867.d03t01

low T low testosterone cost costs low testosterone deficiency

shared by Nathan Goodyear on 16 Feb 13 - No Cached
  • Nathan Goodyear on 16 Feb 13
     
    This study assumes a 13% low T prevalence.  Probably too low.  This will only grow.  Low T contributes to many disease states in men. This study showed a cost of 190-525$ billion in cost from these disease states over a 20 year time period.
Nathan Goodyear

Lifestyle and nutritional imbalances associated with Western diseases: causes and conse... - 0 views

www.jnutbio.com/...fulltext

lifestyle inflammation diet nutrition disease

shared by Nathan Goodyear on 24 Jun 13 - No Cached
  • Nathan Goodyear on 24 Jun 13
     
    This study finds most "western" diseases are the result of environment and only <5% genetic. Evidence is growing that the environment is the largest contributor to disease.  The greatest environment contributor is diet. This is great, because we can change diet...if one wants too. This article also shows are current understanding on how dietary inflammation results in insulin/glucose disruption.
Nathan Goodyear

Widely used pesticides with previous... [Environ Health Perspect. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21310686

pesticides low T Testosterone anti-androgens antiandrogens health men's

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    commonly used pesticides are found to be anti-androgens.  This is growing problem in men today. 
Nathan Goodyear

Pathogenesis of non-alcoholic fatty liver disease - 0 views

qjmed.oxfordjournals.org/...71.full

NAFLD non-alcoholic fatty liver obesity overweight weight-loss inflammation

shared by Nathan Goodyear on 09 Jan 12 - No Cached
  • Nathan Goodyear on 09 Jan 12
     
    The fastest growing liver disease today is NAFLD, which is a direct result of the rising obesity epidemic.  This is a good review of the current understanding on the pathophysiology of NAFLD.
Nathan Goodyear

JCI - Inflammation and insulin resistance - 0 views

www.jci.org/29069

inflammation insulin resistance obesity IR overweight weight-loss

shared by Nathan Goodyear on 10 Jan 12 - No Cached
  • Nathan Goodyear on 10 Jan 12
     
    How does inflammation cause insulin resistance?  This in-depth paper helps to explain the current understanding.   More and more obesity is part of a growing inflammatory epidemic.
Nathan Goodyear

Do Parabens Have the Ability to Interfere with Steroidogenesis? - 0 views

toxsci.oxfordjournals.org/...206.short

parabens butyl-paraben endocrine disruptor

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • Nathan Goodyear on 02 Feb 12
     
    There is growing evidence that some parabens have endocrine disrupting effects.  IN this study, they found that butyl paraben acted as an endocrine disruptor.
Nathan Goodyear

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy... - 1 views

www.nature.com/...nm.2890.html

chemotherapy cancer CA WNT16B prostate tumor resistance

shared by Nathan Goodyear on 11 Aug 12 - No Cached
  • Nathan Goodyear on 11 Aug 12
     
    study shows how chemotherapy can contribute to treatment resistance by the growing cancer.  This is done through the secretion of a protein called WNT16B.  This protective protein increases tumor growth.
Nathan Goodyear

http://www.europeanurology.com/article/S0302-2838(08)01435-8/pdf/Oestrogens+and+Prostat... - 0 views

www.europeanurology.com/...el+Concepts+about+an+Old+Issue

prostate cancer estrogen 3-beta androstanediol DHT androgens Testosterone male men hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached
  • Nathan Goodyear on 20 Jan 14
     
    Nice review of the proposed complex interaction between hormones and prostate cancer.  The complex nature of the development of cancer will likely eliminate the complete elucidation of the mechanism of prostate cancer.  However, there are many pieces that would favor: increased aromatase activity appears to play a significant role int he development of prostate cancer, clearly intraprostatic hormones are different than serum making serum evaluation of sex hormones irrelevant--the move should be to salivary hormones, and the growing knowledge of DHT metabolites in the protection of prostate cancer--3 beta androstanediol.
Amelie warner

Dragon Gorge - 0 views

www.haocha.co.uk/...dragon-tea-1

Oolong Tea Dragon Gorge Mountain teas

shared by Amelie warner on 23 Jan 14 - No Cached
  • Amelie warner on 23 Jan 14
     
    This tea, which grows in one of the premier mountain where is over 1800 meters from sea level, delivers on its extreme fresh fragrance... #haocha http://bit.ly/1feEDAX
  • Amelie warner on 11 Feb 14
     
    This tea, which grows in one of the premier mountain where is over 1800 meters from sea level, delivers on its extreme fresh fragrance and taste. After the gentle... #tea #greentea #oolongtea #dranontea #mountintea http://bit.ly/1feEDAX
Nathan Goodyear

PLOS ONE: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Ther... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0085805

Testosterone therapy cardiovascular disease men male hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • For all TT prescription subjects combined, the post/pre prescription rate ratio for MI (RR)was 1.36
  • In men aged 65 years and older the RR was 2.19 (1.27, 3.77), while in men under age 65 years the RR was 1.17
  • increasing RR with increasing age.
  • ...20 more annotations...
  • The RRs were 0.95 (0.54, 1.67) under 55 years
  • 1.35 (0.77, 2.38) at 55–59
  • 1.29 (0.71, 2.35) at 60–64,
  • 1.35 (0.44, 4.18) at 65–69, 1.62
  • 3.43 (1.54, 7.66) at 75 years and older
  • The adjusted post/pre RR for PDE5I across all ages was 1.08
  • For TT prescription, in men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease and 0.90 (0.61, 1.34) for those without
  • In men aged 65 year and older, the RR was 2.16 (0.92, 5.10) for those with a history of heart disease and 2.21 (1.09, 4.45) for those without.
  • Among men aged 65 years and older, we observed a two-fold increase in the risk of MI in the 90 days after filling an initial TT prescription
  • Among younger men with a history of heart disease, we observed a two to three-fold increased risk of MI in the 90 days following an initial TT prescription and no excess risk in younger men without such a history
  • Among older men, the two-fold increased risk was associated with TT prescription regardless of cardiovascular disease history
  • our own findings appear consistent with a higher frequency of thrombotic events following TT prescription among men with more extensive coronary vascular disease.
  • Our findings are consistent with a recent meta-analysis of placebo-controlled randomized trials of testosterone therapy lasting 12 or more weeks among mainly older men, which reported that testosterone therapy increased the risk of adverse cardiovascular-related events (OR = 1.54, 95%CI:1.09, 2.18), as well as serious adverse cardiovascular-related events (OR = 1.61, 95%CI:1.01, 2.56) which included myocardial infarction along with other conditions
  • This association appeared unrelated to average baseline testosterone level (p = 0.70) but varied by source of funding (p = 0.03), with a stronger summary effect in a meta-analysis of studies not funded by the pharmaceutical industry (OR = 2.06, 95%CI:1.34, 3.17) compared with studies funded by the pharmaceutical industry
    • Nathan Goodyear
      Nathan Goodyear on 30 Jan 14
       
      This supports prior analysis that studies done by pharmaceutical corps will be more favorable to their product(s) than those independently funded.  This is called bias.
  • the evidence supports an association between testosterone therapy and risk of serious, adverse cardiovascular-related events–including non-fatal myocardial infarction–in men
  • there is some evidence that low endogenous testosterone levels may also be positively associated with cardiovascular events
  • effects of endogenous and exogenous testosterone may differ. Exogenous testosterone (TT) is associated with physiologic changes that predispose to clotting and thrombotic disorders including increased blood pressure [18], polycythemia [19], reductions in HDL cholesterol [18], [20], and hyperviscosity of the blood and platelet aggregation. [20]–[23]; TT also increases circulating estrogens [24], [25] which may play a role in the observed excess of adverse cardiovascular-related events, given that estrogen therapy has been associated with this excess in both men and women
  • did not include information on the serologic or diagnostic indications for treatment.
  • no association between PDE5I prescriptions and the risk of MI
  • Recently TT has been increasing extraordinarily rapidly, including among younger men and among those without hormone measurement
  • Nathan Goodyear on 30 Jan 14
     
    New cohort study finds increased risk of Testosterone in men > 65 and those : these are based in marketing-based medicine not evidence based medicine.
Nathan Goodyear

Reduced breast cancer incidence in women treated with subcutaneous testosterone, or tes... - 0 views

www.maturitas.org/...abstract

Testosterone aromatase breast cancer anastrazole women female hormone hormones

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    Study finds that Testosterone with or with the aromatase inhibitor anastrazole as a pellet reduced breast cancer risk.  This conclusion should be taken with caution.  It is well know that abnormal breast tissue, breast cancer, highly expresses aromatase activity which would increase Testosterone to estradiol production.  This would feed any growing tumor.  But, this study finds protection.  The failure of this study is the measurement of hormone levels.
Nathan Goodyear

Mitochondrial oxidative stress and the metabolic syndrome - 0 views

www.cell.com/...S1043-2760(12)00114-2

Mitochondria metabolic syndrome metabolic syndrome

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    Growing body of evidence points to mitochondria as an integral component in Metabolic Syndrome.
Nathan Goodyear

Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and l... - 0 views

joe.endocrinology-journals.org/...483

prostate BPH estradiol Testosterone men male hormone hormones aromatase

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    Much has been debated about the effects of androgens on prostate growth.  However, growing evidence is emerging that prostatic aromatase activity is responsible.  This study finds that high aromatase activity and thus Testosterone to Estradiol conversion in the prostate stroma is responsible for the pathogenesis of BPH.
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