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Nathan Goodyear

Salivary cortisol patterns in vital exhaustion. [J Psychosom Res. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11164057

saliva salivary cortisol fatigue vital exhaustion HPA hormone hormones

shared by Nathan Goodyear on 02 May 12 - No Cached
  • Nathan Goodyear on 02 May 12
     
    "vital exhaustion" associated with suppressed HPA activity and low cortisol.
Nathan Goodyear

scientific evidence of ALCAT Test - 0 views

dl-web.dropbox.com/...Complete%20Copy%2012-14-11.pdf

ALCAT food sensitivity test weight loss obesity

shared by Nathan Goodyear on 02 Jan 12 - No Cached
  • Nathan Goodyear on 02 Jan 12
     
    This is an exhaustive review and discussion of the evidence supporting the ALCAT test.
Nathan Goodyear

http://www.curcumin.co.nz/pdf/Curcumin_Getting_Back_To_The_Roots.pdf - 0 views

www.curcumin.co.nz/..._Getting_Back_To_The_Roots.pdf

curcumin turmeric disease natural therapy treatment

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Great, exhaustive review of turmeric and disease.
Nathan Goodyear

Polysaccharides from Cordyceps sinensis mycelium ... [Pharm Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24047103

Cordyceps Cordyceps sinensis exercise performance oxidative stress

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Mouse model finds that Cordyceps increased the interval to exhaustive exercise induced oxidative stress.  SOD, Cat, and GPx were increased in the low, intermediate, and high dose Cordyceps groups.  Oxidative stress markers MDA and 8-OHdG were lower in all groups
Sonny Cher

Activate Party Pills: The Natural Energy Booster - 1 views

Being a full time mom, wife and career woman is never an easy feat. But after juggling heaps of tasks, at the end of the day I always feel tired and exhausted. I do not have time anymore for myself...

legal highs

started by Sonny Cher on 23 May 11 no follow-up yet
Nathan Goodyear

The mineral selenium proves itself as powerful anti-cancer medicine - 0 views

www.naturalnews.com/016446.html

selenium cancer

shared by Nathan Goodyear on 12 May 11 - Cached
  • In a December 1996 article in the Journal of the American Medical Association, Dr. Larry Clark presented evidence that supplemental selenium could reduce cancer death rates by as much as 50%
  • patients receiving selenium had a 67% decrease in cancer of the prostate, a 58 percent decrease in colon or rectal cancer and a 45% decrease in lung cancer
  • An article in the Journal of the American Medical Association (JAMA) by Clark et al. (1996) showed that 200 mcg of supplemental selenium a day reduced overall cancer mortality by 50% in humans compared to a placebo group not receiving supplemental selenium
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  • In a recent five-year study of nearly 30,000 rural Chinese people, researchers from the NCI found that daily doses of these three nutrients reduced cancer deaths by 13%.
  • In a study in Cancer Letters (Evangelou et al. 1997), animals with malignant tumors given high doses of vitamins C and E and selenium manifested a significant prolongation of the mean survival time. Complete remission of tumors developed in 16.8% of the animals
  • cities and states with high selenium content in the soil also had significantly lower rates of cancer, especially of the digestive and urinary systems.
  • In one study of hundreds of men, a daily intake of 200 micrograms of selenium cut the incidence of prostate cancer by 60 percent.
  • The statistics for breast cancer are particularly striking. "The higher the selenium, the lower the breast cancer
  • In Yugoslavia, scientists studied 33 patients with breast cancer. These women had selenium levels in their bloodstream only half those of healthy volunteers.
  • The overall reduction in cancer incidence was 37% in the selenium-supplemented group; a 50% reduction in cancer mortality was observed over a 10-year period
  • The following are the site-specific reductions in cancer incidence observed in the study: colon-rectal cancers (58%), lung cancer (46%), and prostate cancer (63%)
  • A selenium deficiency appears to increase the risk of prostate cancer fourfold to fivefold
  • It was determined that, as the male population ages, selenium levels decrease, paralleling an increase in prostate cancer
  • Nathan Goodyear on 12 May 11
     
    exhaustive discussion selenium deficiency and increased cancer risk
Nathan Goodyear

A Bibliography of Scientific Literature on Fluoride - 0 views

www.slweb.org/bibliography.html

flouride

shared by Nathan Goodyear on 09 Aug 11 - Cached
  • Nathan Goodyear on 09 Aug 11
     
    exhaustive literature collection on the dangers of flouride
Nathan Goodyear

Wiley Online Library: Book Abstract - 0 views

onlinelibrary.wiley.com/...247C94291EA55A4FED221D1.d03t02

flu vaccine vaccination

shared by Nathan Goodyear on 10 Sep 11 - No Cached
  • In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation, 4% of unvaccinated people versus 1% of vaccinated people developed influenza symptoms (risk difference (RD) 3%
  • The corresponding figures for poor vaccine matching were 2% and 1% (RD 1, 95% CI 0% to 3%).
  • Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates
  • ...1 more annotation...
  • Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost. There is no evidence that they affect complications, such as pneumonia, or transmission.
  • Nathan Goodyear on 10 Sep 11
     
    exhaustive review of the flu vaccine data reveals VERY poor matching of vaccine, poor prevention of flu symptoms, and only modest effect on reduction in hospital admission or complication rates.   Final conclusion: "There is no evidence that they affect complications, such as pneumonia, or TRANSMISSION.
Nathan Goodyear

Chemotherapy induces tumor immune evasion by upregulation of programmed cell ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5527486

chemotherapy PD-L1 immune system cancer

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • upregulation of glycolysis in cancer cells, with subsequent exhaustion of glucose in the microenvironment, leading to the death of T cells from starvation
  • PD‐L1 expression promotes the production of interleukin 10, a cytokine involved in the death of activated T cells
  • PD‐L1 expression in tumor tissue might lead to T‐cell exhaustion and unresponsiveness
  • ...1 more annotation...
  • PD‐L1 on cancer cells could induce T‐cell apoptosis through
  • Nathan Goodyear on 16 Feb 21
     
    Chemotherapy found to increase PD-L1 expression in vitro and in vivo studies.
Nathan Goodyear

Do Masks Work? A Review Of The Evidence | ZeroHedge - 0 views

www.zerohedge.com/...do-masks-work-review-evidence

masks

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Not a research article itself, but one of the more descriptive and exhaustive review of the literature on masks I have found to date.
Nathan Goodyear

CD40 may be key to activating immune response in pancreatic cancer - 0 views

www.healio.com/...-response-in-pancreatic-cancer

immunology immunotherapy cancer immune immuneCD40 immune system check point inhibitors

shared by Nathan Goodyear on 30 Jul 23 - No Cached
  • Nathan Goodyear on 30 Jul 23
     
    "…it seems most patients who respond do so by reactivation of a previously existing immune response that was perhaps exhausted or subverted by the cancer. If you block these brakes that slow an immune response, you can resume immune activity and achieve a remarkable regression in many cases." "…data shows that CD40 is an important switch for converting a tumor from cold to hot."
Nathan Goodyear

ScienceDirect - Biological Psychology : Day-to-day variation in saliva cortisol-Relatio... - 0 views

www.sciencedirect.com/...S0301051109001331

cortisol sleep stress saliva

shared by Nathan Goodyear on 07 Jun 11 - No Cached
  • High evening levels of cortisol were associated with symptoms of stress and poor self-rated health
  • low cortisol levels in the morning were associated with sleepiness at awakening and anxiety, exhaustion, and poor health the day before
  • Nathan Goodyear on 07 Jun 11
     
    lack of sleep increases cortisol in the afternoon/evening of the following day
Sonny Cher

Party All You Want After Work - 1 views

My current job ends at 10 in the evening. However, it is my friend's homecoming party and he invited me to come by after work. I knew I would definitely feel exhausted after work and I am afraid I ...

stimulants

started by Sonny Cher on 17 May 11 no follow-up yet
Meredith Blige

Aid For Snoring Problem - 2 views

My wife would always complain about my snoring a lot. Before, I thought it was just because I was exhausted from work, but as time goes by, I am already afraid my snoring is getting worse, that eve...

how can I stop snoring

started by Meredith Blige on 19 Jul 11 no follow-up yet
Sonny Cher

Party All You Want After Work - 1 views

My current job ends at 10 in the evening. However, it is my friend's homecoming party and he invited me to come by after work. I knew I would definitely feel exhausted after work and I am afraid I ...

stimulants

started by Sonny Cher on 20 Apr 11 no follow-up yet
Nathan Goodyear

Intravenous Fluid Use in Athletes - 0 views

www.ncbi.nlm.nih.gov/...PMC3435915

IV intravenous fluid nutrition athletes athlete sports medicine sports exercise

shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • Treatment of exercise-associated hyponatremia with hypertonic IV infusion to correct plasma sodium levels is also a standard and accepted use of IV fluid infusions
  • athletes who present for medical care with hypernatremia who cannot tolerate oral fluids can benefit from IV fluids
  • Vaporization of sweat accounts for 80% of heat loss in hot, dry atmospheric conditions. This mechanism of water loss is the major contributor for exercise-associated dehydration
  • ...30 more annotations...
  • The rate of water loss can be quantified through measurement of sweat rate
  • Pre- and postexercise body weight measurements are the most common means to estimate overall water loss but are condition specific
  • It appears that 1% to 2% body weight loss is well tolerated by the exercising athlete
  • Dehydration, defined as greater than 2% loss of body weight, can negatively affect performance
  • In highly trained endurance athletes, plasma volume and sodium serum concentration were preserved despite a 5% body weight loss
  • In Ironman triathletes, dehydration to 5% body weight loss did not correlate with occurrence of medical complications
  • hydration should begin hours prior to exercise, especially if known deficits are present, and fluids should be consumed at a slow, steady rate, with 5 to 7 mL/kg taken 4 hours prior to exercise
  • Sodium concentration did not produce significant changes in the rate of absorption but was primarily dependent on carbohydrate concentration
  • Replacing 150% of body weight loss over 60 minutes has been tolerated without complications
  • IV treatment of severe dehydration (>7% body weight loss), exertional heat illness, nausea, emesis, or diarrhea, and in those who cannot ingest oral fluids for other reasons, is clinically indicated
  • A recent survey of the National Football League teams revealed that 75% (24 of 32) of the teams utilized IV infusion of fluids for prehydration in at least some otherwise healthy individuals
  • In the National Football League, an average of 1.5 L of normal saline was administered approximately 2.5 hours prior to competition
  • after 2 hours of exercise, the rectal temperature was 0.6° higher in the group not receiving IV infusion. Also, stroke volume and cardiac output were 11% to 16% lower in the control group versus the IV infusion group.
  • Recent evidence suggests the etiology of EAMC is related to muscle fatigue and neuronal excitability
  • no correlation between hydration status or electrolyte concentrations with EAMC
  • there may be a subset of muscle cramping that is associated with a loss of both body fluid and sodium
  • Glycerol is the primary agent for oral hyperhydration
  • elevation of plasma volume by 200 to 300 mL via dextran infusion resulted in 15% increase in stroke volume, 4% increase in VO2 max, and an increase in the exercise time to fatigue
  • Neither the tonicity nor mode of hydration resulted in improved speed of rehydration, greater fluid retention, or improved performance
  • There are beneficial anecdotal reports of EAMC treatment in elite and professional-level athletes with IV hydration during the course of an event
  • Plasma volume was better restored during rehydration with IV fluids at preexercise and 5 minutes of exercise. At 15 minutes, there was no difference between IV and oral rehydration
  • More rapid restoration of plasma volume was accomplished in the IV treatment group with no advantages over oral rehydration in physiological strain, heat tolerance, ratings of perceived effort, or thermal sensations
  • No difference was found in exercise time to exhaustion. IV and oral rehydration methods were equally effective. Heart rates were statistically higher in the oral rehydration group through 75 minutes of exercise, and there were higher increases in norepinephrine plasma concentrations
  • No significant differences between the groups were found for time to recovery, number of days with pain, number of days with stiffness, sleep disturbance, fatigue, rectal temperature, and loss of appetite
  • The current data suggest that IV rehydration is faster than oral
  • There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
  • Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
  • The use of IV fluid may be beneficial for a subset of fluid sensitive athletes
  • this should be reserved for high-level athletes with strong histories of symptoms in well-monitored settings.
  • Volume expanders may also be beneficial for some athletes
  • Nathan Goodyear on 13 Jan 15
     
    to be read
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