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Nathan Goodyear

Chemotherapy induces tumor immune evasion by upregulation of programmed cell ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5527486

chemotherapy PD-L1 immune system cancer

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • upregulation of glycolysis in cancer cells, with subsequent exhaustion of glucose in the microenvironment, leading to the death of T cells from starvation
  • PD‐L1 expression promotes the production of interleukin 10, a cytokine involved in the death of activated T cells
  • PD‐L1 expression in tumor tissue might lead to T‐cell exhaustion and unresponsiveness
  • ...1 more annotation...
  • PD‐L1 on cancer cells could induce T‐cell apoptosis through
  • Nathan Goodyear on 16 Feb 21
     
    Chemotherapy found to increase PD-L1 expression in vitro and in vivo studies.
Nathan Goodyear

Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer - ScienceDirect - 0 views

www.sciencedirect.com/...S1550413122005046

TME ammonia T cells tumor microenvironment

shared by Nathan Goodyear on 27 Dec 22 - No Cached
  • Nathan Goodyear on 27 Dec 22
     
    Interesting: mouse model finds ammonia in TME inhibits T cell function.
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