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Nathan Goodyear

Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acry... - 0 views

www.researchgate.net/...-induced_neurotoxicity_in_rats

RG3 panax ginseng neurotoxin brain acrylamide hormones

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    RG3, an extract from panax ginseng, found to protect against the neurotoxin acrylamide.   Also of interest, is that serotonin, corticosterone, T3, T4, estradiol, progesterone and epinephrine were all decreased in this acrylamide rat model.
Nathan Goodyear

11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18230901

11-betaHSD1 fat adipose tissue adipoxytes liver metabolic syndrome insulin resistance dyslipidemia hypertension fatty

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but not systemic corticosterone levels, abdominal obesity, hyperglycaemia, insulin resistance, dyslipidaemia and hypertension
  • transgenic overexpression of 11beta -HSD1 in liver yielded an attenuated metabolic syndrome with mild insulin resistance, dyslipidaemia, hypertension and fatty liver, but not obesity or glucose intolerance
  • Nathan Goodyear on 14 Mar 12
     
    11-betaHSD1 expression and effect is site specific.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.full

DHT 3 beta androstanediol androgens Hypothalamus HPA hormones stress

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  • Nathan Goodyear on 15 Jul 15
     
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbi... - 0 views

www.sciencedirect.com/...S0092867413004625

gut microbiota microflora flora intestinal epithelial cells metabolism TLRs MAMPs

shared by Nathan Goodyear on 20 Oct 14 - No Cached
  • a lack of microbiota results in a permanent ileal overproduction of corticosterone due to decreased expression of the D-box-binding E4BP4 repressor. This hypercorticosterolism generates systemic metabolic defects (hyperglycemia, insulin resistance, increased TG and FA)
  • Nathan Goodyear on 20 Oct 14
     
    to be read article on the communication between gut microbiota and intestinal epithelial cells and the resultant metabolic impact.
Nathan Goodyear

The latest weapon against cancer is ... a keto diet? | Cold Spring Harbor Laboratory - 0 views

www.cshl.edu/-against-cancer-is-a-keto-diet

dexamethasone DEXA ketogenic ferroptosis ketogenic diet cachexia cancer corticosterone

shared by Nathan Goodyear on 31 Dec 23 - No Cached
  • Nathan Goodyear on 31 Dec 23
     
    PR piece for the publication.
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