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Nathan Goodyear

Pesticides in Mississippi air and rain:... [Environ Toxicol Chem. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24549493

pesticides farming glyphosate AMPA xenoestrogens environmental toxins

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    Scary stat--75% of samples from air and rainfall taken in delta contaminated with glyphosate and its metabolite AMPA.  These levels were not measured in 1995 so % increase is unable to be determined.  We do know that roundup use has increased dramatically over that time frame.  
Nathan Goodyear

Aluminum and copper in drinking water enhance... [J Neuroimmunol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16697052

aluminum copper Al Cu brain inflammation oxidative water

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    Aluminum and Copper individually increase brain inflammation, but this study found synergistic effect on inflammation.  This test was in a mouse model using a 3 month introduction of contaminated water.
Nathan Goodyear

PLOS ONE: Metal and Silicate Particles Including Nanoparticles Are Present in Electroni... - 0 views

www.plosone.org/...journal.pone.0057987

electronic cigarette cigarette metals

shared by Nathan Goodyear on 23 Nov 13 - No Cached
  • Nathan Goodyear on 23 Nov 13
     
    study finds equal parts of metal contaminants and silica in electronic cigarettes as in regular cigarettes.  One example is aluminum.  Aluminum is incredibly neurotoxic.
Rahul Sharma

Cellulose Nitrate - CN Gridded Membrane Filters - 0 views

www.axivafilters.com/...gridded-membrane-c-n-filters

CN Gridded Membrane Filters

shared by Rahul Sharma on 18 Oct 19 - No Cached
  • Rahul Sharma on 18 Oct 19
     
    Buy best quality CN Gridded Membrane Filters at Axiva. This membrane filters are ideal for analytical method requiring qualitative, enrichment method microorganism counts for the detection of microbial contamination in food beverages, pharmaceuticals and cosmetics.
Nathan Goodyear

Common environmental contaminant, cadmium, linked to rapid breast cancer cell growth - 0 views

www.sciencedaily.com/...120423184203.htm

cadmium breast cancer endocrine disruptor xenoestrogen estrogen environmental

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    cadmium increases growth potential of breast cancer.  No surprise, cadmium is a classic endocrine disruptor that mimics estrogen.
Nathan Goodyear

BMC Medicine | Abstract | DNA barcoding detects contamination and substitution in North... - 0 views

www.biomedcentral.com/...abstract

herbs herbal products

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    This study found that herbal supplements are not what they claim to be.  The problem here is they didn't publish the companies that were found to be dishonest and then presenting this as a broad represetntation of the industry.  That is intellectual malpractice.  Herbs have observation of thousands of years of their efficacy.  Some companies choose to skimp and falsify components for profit.  This might be the cause of the difference between a $5 bottle of herbs from WalMart and a $50 dollar from a reputable supplier.  This by no means invalidates herbs.
Nathan Goodyear

The multitude and diversity of environmental carci... [Environ Res. 2007] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...17692309

environmental carcinogens

shared by Nathan Goodyear on 28 Mar 11 - No Cached
  • Of major concerns are: outdoor air pollution by carbon particles associated with polycyclic aromatic hydrocarbons; indoor air pollution by environmental tobacco smoke, formaldehyde and volatile organic compounds such as benzene and 1,3 butadiene, which may particularly affect children, and food pollution by food additives and by carcinogenic contaminants such as nitrates, pesticides, dioxins and other organochlorines. In addition, carcinogenic metals and metalloids, pharmaceutical medicines and cosmetics may be involved
  • Nathan Goodyear on 28 Mar 11
     
    diversity of environmental carcinogens
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3608474

Fenton reaction ferritin vitamin C Fe cancer

shared by Nathan Goodyear on 07 Jul 19 - No Cached
  • iron and ascorbate has long been used as an oxidizing system; the combination of these two reagents is referred to as the Udenfriend system
  • ascorbate serves as a reducing cofactor for many enzymes
  • uptake of ascorbate from the intestinal tract is very tightly controlled
  • ...11 more annotations...
  • pharmacokinetic data indicate that intravenous administration of ascorbate can bypass this tight control resulting in highly elevated plasma levels
  • ascorbate readily oxidizes to produce H2O2, pharmacological ascorbate has been proposed as a prodrug for the delivery of H2O2 to tumors
  • Ascorbate is an excellent reducing agent and readily undergoes two consecutive, one-electron oxidations to form ascorbate radical (Asc•−) and dehydroascorbic acid (DHA)
  • Ascorbate oxidizes readily. The rate of oxidation is dependent on pH and is accelerated by catalytic metals
  • In near-neutral buffers with contaminating metals, the oxidation and subsequent loss of ascorbate can be very rapid
  • Ascorbate is required for maintaining iron in the ferrous state
  • In the presence of catalytic metal ions, ascorbate can also exert pro-oxidant effects
  • Ascorbate is an excellent one-electron reducing agent that can reduce ferric (Fe3+) to ferrous (Fe2+) iron, while being oxidized to ascorbate radical
  • In a classic Fenton reaction, Fe2+ reacts with H2O2 to generate Fe3+ and the very oxidizing hydroxyl radical
  • e presence of ascorbate can allow the recycling of Fe3+ back to Fe2+, which in turn will catalyze the formation of highly reactive oxidants from H2O2
  • Depending on concentrations, the effects of ascorbate on models of lipid peroxidation can be pro- or antioxidant
  • Nathan Goodyear on 07 Jul 19
     
    ferritin released enhanced pharmacologic ascorbate induced-cytotoxicity, indicating that ferritin with high iron-saturation could be a source of catalytic iron. Consistent with this, ascorbate has also been shown to be capable of releasing iron from cellular ferritin
Nathan Goodyear

Fish Intake, Contaminants, and Human Health | Nutrition | JAMA | The JAMA Network - 0 views

jamanetwork.com/...203640

omega 3 omega-3 fish EPA DHA diet nutrition

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Study finds that higher omega 3 intake over time associated with a reduction in blood clots, heart arrhythmias, lower triglycerides, lower heart rates and lower blood pressure.
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