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Nathan Goodyear

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views

www.pnas.org/...8749

cancer vitamin C

shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Nathan Goodyear on 06 Oct 18
     
    In vivo study of vitamin C IV found to produce H2O2 which is key to the prooxidant effect of vitamin C against cancer.
Nathan Goodyear

Intravenous vitamin C in the supportive care of cancer patients: a review and rational ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5927785

cancer vitamin C IV vitamin C

shared by Nathan Goodyear on 14 May 19 - No Cached
  • Nathan Goodyear on 14 May 19
     
    Recent publication on vitamin C in cancer.
Nathan Goodyear

Vitamin C and cancer revisited - 0 views

www.ncbi.nlm.nih.gov/...PMC2516245

IV vitamin C cancer vitamin C H2O2 hydrogen peroxide Fe

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions (5) because it does not readily autoxidize, i.e., react with oxygen (O2) to produce reactive oxygen species, such as superoxide radicals (O2•−) or H2O2
  • However, ascorbate readily donates an electron to redox-active transition metal ions, such as cupric (Cu2+) or ferric (Fe3+) ions, reducing them to cuprous (Cu+) and ferrous (Fe2+) ions, respectively
  • Reduced transition metal ions, in contrast to ascorbic acid, readily react with O2, reducing it to superoxide radicals (Reaction 2), which in turn dismutate to form H2O2 and O2
  • ...6 more annotations...
  • The H2O2 produced this way (Reactions 1–3) seems to be key to ascorbate's antitumor effect because H2O2 causes cancer cells to undergo apoptosis, pyknosis, and necrosis
  • In contrast, normal cells are considerably less vulnerable to H2O2
  • The reason for the increased sensitivity of tumor cells to H2O2 is not clear but may be due to lower antioxidant defenses
  • In fact, a lower capacity to destroy H2O2—e.g., by catalase, peroxiredoxins, and GSH peroxidases—may cause tumor cells to grow and proliferate more rapidly than normal cells in response to low concentrations of H2O2
  • These observations, combined with the inhibitory effect on xenograft growth, provide the proof of concept that millimolar concentrations of extracellular ascorbate, achievable by i.p. injection or i.v. infusion in experimental animals and humans, respectively, exert pro-oxidant, antitumor effects in vivo.
  • They also show that the concentration of the ascorbyl radical correlates with the concentration of H2O2 in interstitial fluid, whereas no H2O2 can be detected in blood or plasma
  • Nathan Goodyear on 05 Mar 18
     
    review of the mechanism of how extracellular AA, only obtainable from parenteral dosing, can produce H2O2 extracellularly to then be cytotoxic to cancer cells.
Nathan Goodyear

Vitamin C biosynthesis | Learn Science at Scitable - 0 views

www.nature.com/...-mystery-of-vitamin-c-14167861

vitamin c

shared by Nathan Goodyear on 04 Feb 18 - No Cached
  • Nathan Goodyear on 04 Feb 18
     
    great review on the metabolism of vitamin C.
Nathan Goodyear

Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasm... - 0 views

watermark.silverchair.com/dkf104.pdf

artesunate vitamin C fenton reaction doxycycline

shared by Nathan Goodyear on 07 Jul 19 - No Cached
  • Nathan Goodyear on 07 Jul 19
     
    Study finds that vitamin C inhibits pro-oxidant effects of artesunate at doses of 400 microM/L; Same with doxycycline. The problem here is that that translates to 5 mg/dL of vitamin C. Studies have shown that vitamin C's effect in cancer is attributable in part to its dose and the presence of metals.
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3608474

"Vitamin C" cancer Fe Iron

shared by Nathan Goodyear on 02 Dec 18 - No Cached
  • Nathan Goodyear on 02 Dec 18
     
    Nice review of the effects of vitamin C as a reducer of metals in cancer. This plays a role in the effects of vitamin C in cancer.
Nathan Goodyear

Antioxidant and pro-oxidant activity of Vitamin C in oral environment Chakraborthy A, R... - 0 views

www.ijdr.in/article.asp

vitamin c pro-oxidant antioxidant cancer IV vitamin c

shared by Nathan Goodyear on 11 Jul 19 - No Cached
  • Nathan Goodyear on 11 Jul 19
     
    Vitamin C has both antioxidant and pro-oxidant effects
Nathan Goodyear

The Association of Vitamins C and K3 Kills Cancer Cells Mainly by Autoschizis, a Novel ... - 0 views

IV vitamin C cancer autoschizis vitamin C vitamin K3

shared by Nathan Goodyear on 23 Jul 19 - No Cached
  • Nathan Goodyear on 23 Jul 19
     
    Awesome review of the combination approach to vitamin C and K3 to induce oxidative cytotoxicity and autoschizis of cancer cells.
Nathan Goodyear

Opposing effects of low versus high concentrations of water soluble vitamins/dietary in... - 0 views

www.ncbi.nlm.nih.gov/...28755485

vitamin C cancer colorectal cancer niacin

shared by Nathan Goodyear on 18 Aug 19 - No Cached
  • Nathan Goodyear on 18 Aug 19
     
    High dose vitamin C + high dose niacin kill CSCs, but low dose stimulates CSCs.
Nathan Goodyear

Role of Vitamin C in Skin Diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC6040229

melanoma vitamin C IV vitamin C

shared by Nathan Goodyear on 20 Aug 19 - No Cached
  • Nathan Goodyear on 20 Aug 19
     
    High dose IV vitamin C effective against melanoma review finds. Low dose appears to promote melanoma.
Nathan Goodyear

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel ... - 0 views

vitamin cancer vitamin C autoschizis IV vitamin C vitamin K3

shared by Nathan Goodyear on 24 Jul 19 - No Cached
  • Nathan Goodyear on 24 Jul 19
     
    Nice review of the adjuvant effects of vitamin C and vitamin K3 in the process of autoschizis of cancer cells.
Nathan Goodyear

Frontiers | Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge - 0 views

www.frontiersin.org/...full

vitamin C transporters cancer vitamin C

shared by Nathan Goodyear on 11 Aug 19 - No Cached
  • Nathan Goodyear on 11 Aug 19
     
    Good review on the SVCT and GLUT transporters of vitamin C.
Nathan Goodyear

Plasma Vitamin C Is Lower in Postherpetic Neuralgia Patients... : The Clinical Journal ... - 0 views

journals.lww.com/...s_Lower_in_Postherpetic.2.aspx

vitamin c IV vitamin C shingles

shared by Nathan Goodyear on 17 May 17 - No Cached
  • Nathan Goodyear on 17 May 17
     
    IV vitamin C found to reduce pain in small study of people with shingles.
Nathan Goodyear

Vitamin C revisited | Critical Care | Full Text - 0 views

ccforum.biomedcentral.com/...s13054-014-0460-x

IV vitamin C vitamin C sepsis stroke oxidative stress LPS

shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    Great read on IV vitamin C in the critically ill.
Nathan Goodyear

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in P... - 0 views

www.ncbi.nlm.nih.gov/...PMC7830882

VEGF IV vitamin C vitamin C colon cancer hypoxia HIF-1alpha cancer HIF-1 GLUT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Very interesting study. They gave IV vitamin C up to 75 grams to increase tumor delivery and found there was correlation between plasma and tumor levels post resection. This correlation was to a point-saturation curve. Also, there was a reduction in VEGF and hypoxia scores.
Nathan Goodyear

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence - 0 views

www.ncbi.nlm.nih.gov/...PMC6037948

vitamin C epigenetics GLUT HIF-1alpha cancer IV vitamin C SVCT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Great review of the many different potential mechanisms of action of vitamin C in the the treatment of cancer.
Nathan Goodyear

High-Dose Vitamin C in Advanced-Stage Cancer Patients - 0 views

www.ncbi.nlm.nih.gov/...PMC7996511

HIF-1 cancer HIF-1alpha IV vitamin C chemotherapy SVCT GLUT vitamin C

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    When is enough literature enough? Vitamin C is a powerful adjunct in cancer treatment, i.e. chemotherapy
Nathan Goodyear

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of a... - 0 views

www.sciencedirect.com/...S0891584916304087

hypoxia VEGF HIF-1alpha vitamin C HIF-1 cancer GLUT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Very nice mouse study. They reduced hypoxia signialing, HIF-1alpha, via daily vitamin C administration. Also a very interesting point, that the vitamin C had a much longer half life within the tumor than normal tissue-up to 48 hours compared to 30 minutes in normal. So, that begs the question, what does higher dose do? In this study they also saw a reduction in angiogenesis and tumor growth.
Nathan Goodyear

Low-Dose Naltrexone in Combination with High-Dose Vitamin C in Cancer Patients: Our Exp... - 0 views

LDN metastasis IV vitamin C vitamin C cancer High dose IV vitamin C dose high dose vitamin C low naltrexone)

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    Review of one clinics experience with HDIVC and LDN.
Nathan Goodyear

Combined treatment with vitamin C and methotrexate inhibits triple-negative breast canc... - 0 views

www.spandidos-publications.com/...or.2017.5439

IV vitamin C breast cancer EGFR triple negative breast cancer vitamin C TNBC Caspase-3 methotrexate

shared by Nathan Goodyear on 15 Mar 21 - No Cached
  • Nathan Goodyear on 15 Mar 21
     
    Low dose methotrexate + low dose vitamin C inhibit TNBC via EGFR mechanism
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