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Nathan Goodyear

(PDF) Insulin-induced enhancement of antitumoral response to methotrexate in breast can... - 0 views

www.researchgate.net/...xate_in_breast_cancer_patients

cancer IPT breast cancer

shared by Nathan Goodyear on 04 Jul 18 - No Cached
  • Nathan Goodyear on 04 Jul 18
     
    IPT with methotrexate beneficial beyond methotrexate alone.
Nathan Goodyear

Combined treatment with vitamin C and methotrexate inhibits triple-negative breast canc... - 0 views

www.spandidos-publications.com/...or.2017.5439

IV vitamin C breast cancer EGFR triple negative breast cancer vitamin C TNBC Caspase-3 methotrexate

shared by Nathan Goodyear on 15 Mar 21 - No Cached
  • Nathan Goodyear on 15 Mar 21
     
    Low dose methotrexate + low dose vitamin C inhibit TNBC via EGFR mechanism
Nathan Goodyear

Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of activ... - 0 views

ard.bmj.com/...annrheumdis-2013-204807

thunder god vine Tripterygium wilfordii rheumatoid arthritis joint pain

shared by Nathan Goodyear on 21 Apr 14 - No Cached
  • Nathan Goodyear on 21 Apr 14
     
    Thunder god vine found to equal the effects of methotrexate in the treatment of rheumatoid arthritis joint pain.
Nathan Goodyear

Inhibition of in vitro vascular endothelial cell proliferation and in vivo ne... - 0 views

onlinelibrary.wiley.com/...anr.1780320903

low-dose chemotherapy RA rheumatoid arthritis angiogenesis

shared by Nathan Goodyear on 24 Aug 20 - No Cached
  • Nathan Goodyear on 24 Aug 20
     
    Low-dose methotrexate is anti-angiogenic.
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
Nathan Goodyear

Medical ozone increases methotrexate clinical response and improves cellular redox bala... - 0 views

www.sciencedirect.com/...S001429991630471X

ozone

shared by Nathan Goodyear on 31 Jul 18 - No Cached
  • Nathan Goodyear on 31 Jul 18
     
    ozone
Nathan Goodyear

Medical ozone increases methotrexate clinical response and improves cellular redox bala... - 0 views

www.researchgate.net/...ents_with_rheumatoid_arthritis

Ozone

shared by Nathan Goodyear on 31 Jul 18 - No Cached
  • Nathan Goodyear on 31 Jul 18
     
    Ozone
Nathan Goodyear

A phase II study of high-dose celecoxib and metronomic 'low-dose' cyclophosphamide and ... - 0 views

pubmed.ncbi.nlm.nih.gov/20231809

angiogenesis metronomic chemotherapy celebrex

shared by Nathan Goodyear on 09 Sep 21 - No Cached
  • Nathan Goodyear on 09 Sep 21
     
    Oral metronomic chemotherapy with celebrex shown to provide appx 50% stable NHL disease in refractory NHL.
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