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Nathan Goodyear

PLOS ONE: Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practiti... - 0 views

www.plosone.org/...journal.pone.0011414

IV vitamin C vitamin C intravenous alternative medicine complementary alternative

shared by Nathan Goodyear on 29 Sep 13 - No Cached
  • Nathan Goodyear on 29 Sep 13
     
    Rare side effects of high dose vitamin C.  Proven to be very safe compared to even labeled use of FDA approved drugs.
Nathan Goodyear

Treatment of chronic hepatitis C virus ... [J Clin Gastroenterol. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16082287

IV vitamin C hepatitis IV intravenous vitamin C antioxidant therapy antioxidants

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    Treatment of chronic Hepatitis with antioxidants, particularly IV vitamin C with glutathione, B complex and glycyrrhizin results in normalization of liver enzymes in 44% of patients with elevated enzymes with HCV.
Nathan Goodyear

Phase I clinical trial of i.v. ascorbic acid in ad... [Ann Oncol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/pubmed

IV vitamin C vitamin C intravenous IV vitamin C cancer

shared by Nathan Goodyear on 02 Oct 13 - No Cached
  • Nathan Goodyear on 02 Oct 13
     
    High dose IV vitamin C not proven to be effective in patients with advanced cancer, but proven to be very safe.
Nathan Goodyear

The in vitro antitumor activity of vi... [Anticancer Res. 2003 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12926064

IV vitamin C IV vitamin K3 vitamin C vitamin K3 IV vitamin C K K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C and K3 show synergistic activity against ovarian cancer.  
Nathan Goodyear

Autoschizis: another cell death for canc... [Ital J Anat Embryol. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11730000

autoschizis cancer vitamin C vitamin C K K3 vitamin K3 IV vitamin C IV vitamin K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    The autoschizis from IV vitamin C and K3 proposed to be secondary to oxidative stress.
Nathan Goodyear

In vivo reactivation of DNases in impla... [J Histochem Cytochem. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11118483

IV vitamin C IV vitamin K3 vitamin C K K3 DNase vitamin C vitamin K3 prostate cancer

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C/K3 combination therapy reactivates DNase activity in mouse model of prostate cancer.
Nathan Goodyear

Effects of sodium ascorbate (vitamin ... [Anticancer Res. 1993 Jan-Feb] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8476199

IV vitamin C IV vitamin K vitamin K3 C IV vitamin K3 cancer vitamin C vitamin K

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin K3 shown to provide synergy with IV vitamin C in vitro study of cancer cells.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases -- Padayatty et al.... - 0 views

www.cmaj.ca/...937

intravenously vitamin C cancer

shared by Nathan Goodyear on 09 Feb 11 - Cached
  • high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer
  • Nathan Goodyear on 09 Feb 11
     
    High-dose IV vitamin C benefits cancer patients:review of 3 case studies
Nathan Goodyear

Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later - 0 views

ict.sagepub.com/...32.abstract

vitamin C cancer treatment therapy

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    IV vitamin C shown to be highly effective in cancer therapy.  This article is a great review of the literature for IV vitamin C
Nathan Goodyear

Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discov... - 0 views

advances.nutrition.org/...78.full

vitamin C

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • when vitamin C is ingested by mouth, plasma and tissue concentrations are tightly controlled by at least 3 mechanisms in healthy humans: absorption, tissue accumulation, and renal reabsorption
  • 4th mechanism, rate of utilization, may be important in disease
  • Ascorbate administered intravenously has already been tested in a phase I clinical trial, is in wide use by complementary and alternative medicine (integrative medicine) practitioners, and appears to have minimal side effects in patients who are properly screened.
  • Nathan Goodyear on 28 Apr 11
     
    Fantastic review on IV Vitamin C therapy
Nathan Goodyear

Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric ... - 0 views

circres.ahajournals.org/...88

Vitamin C tetrahydrobiopterin

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • beneficial effect of vitamin C on vascular endothelial function appears to be mediated in part by protection of tetrahydrobiopterin and restoration of eNOS enzymatic activity
  • Nathan Goodyear on 29 Apr 11
     
    Vitamin C helps to preserve tetrahydrobiopterin levels
Nathan Goodyear

Urinary glucose and vitamin C. [Am J Clin Pathol. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...920657

Vitamin C DM diabetes

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • vitamin C added, false-positive tests for glucose were found
  • Nathan Goodyear on 13 Jul 11
     
    high dose vitamin C causes false positive glucose elevations
Nathan Goodyear

Alt/Trad Medical Review - 0 views

www.mountainmistbotanicals.com/..._Interactions_Interference.htm

Vitamin C glucose DM diabetes

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • Vitamin C interferes with several glucose tests, including tests diabetics use at home. U
  • rinary glucose test strips will test false positive with as little as 2,000mg of vitamin C daily
  • Nathan Goodyear on 13 Jul 11
     
    Vitamin C will induce false positives on glucose test strips
Nathan Goodyear

http://maxwellsci.com/print/bjpt/v4-232-240.pdf - 0 views

maxwellsci.com/...v4-232-240.pdf

vitamin c liver enzymes Pb lead

shared by Nathan Goodyear on 09 Mar 15 - No Cached
  • Nathan Goodyear on 09 Mar 15
     
    Study finds vitamin C, vitamin E, Magnesium, selenium... associated with decreased negative effects elicited by Lead.  Lead has been shown to induce an elevation in liver enzymes and vitamin C has been shown to reduce this effect through its antioxidant activity.
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

www.ncbi.nlm.nih.gov/...PMC3205506

concussions concussion natural therapies brain curcumin omega 3 resveratrol green tea EGCG EPA DHA vitamin E vitamin c vitamin D

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
  • ...45 more annotations...
  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[150] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[217] relative risk for ischemic stroke,[2] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[128,194,236] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[63,97] Alzheimer's disease,[109] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[97] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[37]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
  • Nathan Goodyear on 20 Feb 16
     
    great review of natural therapies in the treatment of concussions
Nathan Goodyear

Intravenous vitamin C in the supportive care of cancer patients: a review and rational ... - 0 views

www.current-oncology.com/...2712

Cancer vitamin C IV vitamin C

shared by Nathan Goodyear on 16 Nov 18 - No Cached
  • Nathan Goodyear on 16 Nov 18
     
    Review of vitamin C in cancer treatment
Nathan Goodyear

Oncotarget | Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer warburg effect colon cancer

shared by Nathan Goodyear on 02 Jul 18 - No Cached
  • Nathan Goodyear on 02 Jul 18
     
    To be read article on Vitamin C
Nathan Goodyear

The Effects of High Concentrations of Vitamin C on Cancer Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC3798917

cancer leukemia vitamin C IV vitamin C

shared by Nathan Goodyear on 23 Oct 17 - No Cached
  • Nathan Goodyear on 23 Oct 17
     
    Great review of the pharmacological/pharmacodynamic effects of vitamin C in cancer, particularly leukemias.
Nathan Goodyear

Non-toxic potentiation of cancer chemotherapy b... [Int J Cancer. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3666992

IV vitamin C IV vitamin K3 vitamin C K K3 chemotherapy vitamin C vitamin K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C and K3 induces cancer cell death through production of H2O2 in catalase deficient cancer cells.  Pretreament shown to potentiate traditional chemotherapy.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a p... - 0 views

www.pnas.org/...13604

vitamin C cancer

shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Ascorbate is transported into cells as such by sodium-dependent transporters, whereas dehydroascorbic acid is transported into cells by glucose transporters and then immediately reduced internally to ascorbate
  • Nathan Goodyear on 06 Oct 18
     
    vitamin C inhibits tumor growth via prooxidant effect of vitamin C.
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