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Nathan Goodyear

Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C - 0 views

www.ncbi.nlm.nih.gov/...PMC7803449

vitamin C IV vitamin C sepsis

shared by Nathan Goodyear on 02 Feb 21 - No Cached
  • Nathan Goodyear on 02 Feb 21
     
    IV vitamin C effective in bacterial sepsis.
Nathan Goodyear

Vitamin C - A new player in regulation of the cancer epigenome. - PubMed - 0 views

www.ncbi.nlm.nih.gov/...29102482

epigenetics IV vitamin C cancer vitamin C

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Only abstract available here. I will post the full article when I find it. Vitamin C, in addition to its anti-cancer properties, found to change epigenetic expression.
Nathan Goodyear

Aging | Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for... - 0 views

www.aging-us.com/...text

cancer stem cells cancer azithromycin IV vitamin C vitamin C doxycycline CSC

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Triple attack on cancer stem cells. Doxy and Azithromycin with vitamin C found to significantly inhibit CSC mitochondrial activity.
Nathan Goodyear

Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM ... - 0 views

www.ncbi.nlm.nih.gov/...30926564

IV vitamin C vitamin C cancer

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Vitamin C increased the efficacy of bleomycin.
Nathan Goodyear

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress sy... - 1 views

www.ncbi.nlm.nih.gov/...PMC7172861

IV vitamin C cytokine storm acute respiratory distress syndrome ARDS coronavirus COVID19 vitamin C

shared by Nathan Goodyear on 02 Jun 20 - No Cached
  • Nathan Goodyear on 02 Jun 20
     
    IV vitamin C effective against ARDS in COVID19
Nathan Goodyear

THE DIURETIC ACTION OF VITAMIN C - 0 views

IV vitamin C vitamin C diuretic

shared by Nathan Goodyear on 13 May 20 - No Cached
  • Nathan Goodyear on 13 May 20
     
    Vitamin C acts as a diuretic
Nathan Goodyear

Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Qual... - 0 views

www.ncbi.nlm.nih.gov/...PMC6070822

acute myeloid leukemia IV vitamin C vitamin C AML

shared by Nathan Goodyear on 29 May 20 - No Cached
  • Nathan Goodyear on 29 May 20
     
    Case study of IV vitamin C twice weekly for treatment of relapse AML.
Nathan Goodyear

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients:... - 0 views

jintensivecare.biomedcentral.com/...s40560-020-0432-y

ventilation IV vitamin C vitamin C

shared by Nathan Goodyear on 11 Aug 20 - No Cached
  • Nathan Goodyear on 11 Aug 20
     
    Meta-analysis finds that vitamin C shortened ventilation time by 25% in critical ill.
Nathan Goodyear

Vitamin C inhibit the proliferation, migration and epithelial-mesenchymal-tra... - 0 views

www.ncbi.nlm.nih.gov/...PMC4658888

IV vitamin C epithelial to mesenchymal transition EMT vitamin C HIF-1alpha

shared by Nathan Goodyear on 31 Aug 20 - No Cached
  • Nathan Goodyear on 31 Aug 20
     
    Vitamin C inhibits EMT through destabilization of HIF-1alpha.
Nathan Goodyear

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8924116

cancer NETosis SARS-CoV-2 COVID COVID-19 COVID19 platelets

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Pneumonia is a typical symptom of COVID-19 infection, while acute respiratory distress syndrome (ARDS) and multiple organ failure are common in severe COVID-19 patients
  • NETs are important for preventing pathogen invasion, their excessive formation can result in a slew of negative consequences, such as autoimmune inflammation and tissue damage
  • SARS-CoV-2 infection has also been linked to increased neutrophil-to-lymphocyte ratios, which is associated with disease severity and clinical prognosis
  • ...40 more annotations...
  • NETosis is a special form of programmed cell death in neutrophils, which is characterized by the extrusion of DNA, histones, and antimicrobial proteins in a web-like structure known as neutrophil extracellular traps (NETs)
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Definition
  • increased generation of reactive oxygen species (ROS) is a crucial intracellular process that causes NETosis
  • Another indirect route of SARS-CoV-2-induced NET production is platelet activation
  • When NETs are activated in the circulation, they can also induce hypercoagulability and thrombosis
  • In COVID-19, major NET protein cargos of NETs (i.e., NE, MPO, and histones) are significantly elevated.
  • SARS-CoV-2 can also infect host cells through noncanonical receptors such as C-type lectin receptors
  • Immunopathological manifestations, including cytokine storms and impaired adaptive immunity, are the primary drivers behind COVID-19, with neutrophil infiltration being suggested as a significant cause
  • NETosis and NETs are increasingly recognized as causes of vascular injury
  • SARS-CoV-2 and its components (e.g., spike proteins and viral RNA) attach to platelets and increase their activation and aggregation in COVID-19, resulting in vascular injury and thrombosis, both of which are linked to NET formation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Connects SARS-CoV-2 to TLR on Platelets to NETosis to metastasis.
  • NET formation may be caused by activated platelets rather than SARS-CoV-2 itself
  • NETosis, leading to aberrant immunity such as cytokine storms, autoimmune disorders, and immunosuppression.
  • early bacterial coinfections were more prevalent in COVID-19 patients than those infected with other viruses
  • NETosis and NETs may also have a role in the development of post COVID-19 syndromes, including lung fibrosis, neurological disorders, tumor growth, and worsening of concomitant disease
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      NETosis-> tumor growth
  • NETs and other by-products of NETosis have been shown to act as direct inflammation amplifiers. Hyperinflammation
  • “cytokine storm”
  • SARS-CoV-2 drives NETosis and NET formation to allow for the release of free DNA and by-products (e.g., elastases and histones). This may trigger surrounding macrophages and endothelial cells to secrete excessive proinflammatory cytokines and chemokines, which, in turn, enhance NET formation and form a positive feedback of cytokine storms in COVID-19
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Cycle of hyperinflammation
  • NET release enables self-antigen exposure and autoantibody production, thereby increasing the autoinflammatory response
  • patients with COVID-19 who have higher anti-NET antibodies are more likely to be detected with positive autoantibodies [e.g., antinuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA)]
  • COVID-19 NETs may act as potential inducers for autoimmune responses
  • have weakened adaptive immunity as well as a high level of inflammation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Immunomodulation
  • tumor-associated NETosis and NETs promote an immunosuppressive environment in which anti-tumor immunity is compromised
  • NETs have also been shown to enhance macrophage pyroptosis in sepsis
  • facilitating an immunosuppressive microenvironment
  • persistent immunosuppression may result in bacterial co-infection or secondary infection
  • can enhance this process by interacting with neutrophils through toll-like receptor 4 (TLR4), platelet factor 4 (PF4), and extracellular vesicle-dependent processes
  • NET-induced immunosuppression in COVID-19 in the context of co-existing bacterial infection
  • Following initial onset of COVID-19, an estimated 50% or more of COVID-19 survivors may develop multi-organ problems (e.g., pulmonary dysfunction and neurologic impairment) or have worsening concomitant chronic illness
  • NETs in the bronchoalveolar lavage fluid of severe COVID-19 patients cause EMT in lung epithelial cells
  • decreased E-cadherin (an epithelial marker) expression
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Leads to emt
  • COVID-19 also has a long-term influence on tumor progression
  • Patients with tumors have been shown to be more vulnerable to SARS-CoV-2 infection and subsequent development of severe COVID-19
  • patients who have recovered from COVID-19 may have an increased risk of developing cancer or of cancer progression and metastasis
  • awaken cancer cells
  • NETs have been shown to change the tumor microenvironment
  • enhance tumor progression and metastasis
  • vitamin C has been tested in phase 2 clinical trials aimed at reducing COVID-19-associated mortality by reducing excessive activation of the inflammatory response
  • vitamin C is an antioxidant that significantly attenuates PMA-induced NETosis in healthy neutrophils by scavenging ROS
  • vitamin C may also inhibit NETosis and NET production in COVID-19
  • Metformin
  • Vitamin C
  • Nathan Goodyear on 18 Apr 23
     
    NETosis intimately involved in progressive COVID, long COVID, autoimmunity, and cancer
Nathan Goodyear

The effects of surgery on plasma/serum vitamin C concentrations: a systematic review an... - 1 views

www.cambridge.org/...4D74181B088CC6993ED27BA88CDC14

vitamin C surgery

shared by Nathan Goodyear on 29 Jun 22 - No Cached
frankbkelly liked it
  • Nathan Goodyear on 29 Jun 22
     
    Wide-variety of surgeries associated with vitamin C deficiency 1 week post-op that extends to 2-3 months post-op.
Nathan Goodyear

Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonar | DDDT - 0 views

www.dovepress.com/reviewed-fulltext-article-DDDT

vitamin C surgery ascorbic acid

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Vitamin C reduces post-operative pulmonary complications.
Nathan Goodyear

Vitamin C Aids Recovery From Cardiac Surgery | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...-aids-recovery-cardiac-surgery

vitamin C surgery

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Vitamin C improves recovery time in cardiac surgery; also reduces Afib post-cardiac surgery
Nathan Goodyear

Vitamin C deficiency in a university teaching hospital - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/18838532

ascorbic acid hospitalized patients hypovitaminosis hospital vitamin C deficiency hospitals vitamin C

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    60% of hospitalized patients had a subnormal vitamin C concentration and 19% were deficient
Nathan Goodyear

Hypovitaminosis C in hospitalized patients - ScienceDirect - 0 views

www.sciencedirect.com/...S0953620503001808

vitamin C deficiency hypovitaminosis hospital ascorbic acid vitamin C hospitalized patients

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Hospitalized patients are depleted of vitamin C
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