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Nathan Goodyear

Branched-chain amino acids for people with hepatic encephalopathy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25715177

BCAA branched chain amino acids hepatic encephalopathy liver cirrhosis

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    BCAA beneficial in hepatic encephalopathy, but no benefit in mortality, QOL measures, or nutritional parameters due to studies included.
Nathan Goodyear

Branched-Chain Amino Acid Enriched Supplements as Therapy for Liver Disease - 0 views

jn.nutrition.org/...295S.long

BCAA branched chain amino acids liver cirrhosis disease amino acids

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • The most compelling basis for a more widespread prescription of BCAA supplements to patients with cirrhosis is the potential to avert general hepatic decompensation and subsequent death and liver transplantation
  • Nathan Goodyear on 05 Oct 15
     
    Good review of the evidence of BCAA therapy and liver disease.
Nathan Goodyear

A randomized pilot trial of oral branched-chain amino acids in early cirrhosis: Validat... - 0 views

onlinelibrary.wiley.com/...full

BCAA branched chain amino acids liver cirrhosis disease

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  • Nathan Goodyear on 05 Oct 15
     
    BCAA slows cirrhosis progression.  This may prolong the waiting time period for those awaiting transplant.
Nathan Goodyear

American Journal of Gastroenterology - Abstract of article: Effects of Branched-Chain A... - 0 views

www.nature.com/...ajg20119a.html

BCAA branched chain amino acids Muscle mass hepatic encephalopathy liver cirrhosis disease

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    BCAA supplementation does not inhibit recurrences of hepatic encephalopathy, but it does improve muscle mass.
Nathan Goodyear

Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a do... - 0 views

www.sciencedirect.com/...S0016508503003238

BCAA branched chain amino acids liver cirrhosis disease

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    BCAA useful in advanced liver cirrhosis.
Nathan Goodyear

Potential role of branched-chain amino acids in glucose metabolism through the accelera... - 0 views

www.ncbi.nlm.nih.gov/...20506195

BCAA branched chain amino acids liver cirrhosis disease GLUT2 glucose metabolism

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    BCAA improve glucose metabolism via, in part, up regulation of GLUT2 receptors in the liver
Nathan Goodyear

Branched-chain amino acids in liver diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC3837260

BCAA branched chain amino acids liver cirrhosis disease

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Serum concentrations of BCAAs are decreased, while the concentrations of the aromatic amino acids (AAAs) phenylalanine and tyrosine are increased, in patients with advanced liver diseases, resulting in a low ratio of BCAAs to AAAs, a ratio called the Fischer ratio
  • BCAAs were reported to stimulate the production of hepatocyte growth factor
  • a simplified Fischer ratio, the BCAA to tyrosine ratio (BTR), has been reported useful for predicting serum albumin concentration one year later
  • ...10 more annotations...
  • BCAA supplementation was shown to delay the progression of CCl4-induced chronic liver injury in a rat model by reducing hepatic apoptosis
  • BCAAs promoted hepatocyte regeneration in a rat model of hepatectomy
  • BCAA supplementation for advanced cirrhotic patients improves nutritional status and quality of life
  • A low Fischer ratio has been associated with hepatic encephalopathy
  • BCAAs were shown to improve homeostasis model assessment scores for insulin resistance (HOMA-IR) and beta cell function (HOMA-%B) in patients with chronic liver disease, indicating that BCAAs can ameliorate insulin resistance
  • Several clinical trials have suggested that BCAA supplementation improves the prognosis of cirrhotic patients
  • BCAAs activate mTOR and subsequently increase the production of eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase, which upregulate the synthesis of albumin
  • Treatment with BCAAs may therefore have a beneficial effect on patients with hepatic encephalopathy mainly by compensating decreased ratio of BCAAs to AAAs, but not by reducing serum ammonia levels
  • Two randomized studies also showed that BCAAs did not clearly prevent HE in patients with advanced cirrhosis, although BCAAs prevented the progression of hepatic failure
  • a systematic review with meta-analyses on the effect of oral BCAAs for the treatment of HE was published[66]. The review has revealed that supplementation of oral BCAAs in cirrhotic patients inhibits the manifestation of HE, especially in patients with overt HE rather than those with minimal HE, but showed no effect on the survival of those patients[66]. Thus, oral administration of BCAAs is the treatment of choice in cirrhotic patients with HE
  • Nathan Goodyear on 05 Oct 15
     
    good review of BCAA and liver disease: both mechanisms and therapy.
Nathan Goodyear

Hyperammonemia-induced depletion of glutamate and branched-chain am... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8938556

ammonia NH3 BCCA branched chain amino acids glutamine

shared by Nathan Goodyear on 18 Nov 14 - No Cached
  • Nathan Goodyear on 18 Nov 14
     
    Elevated ammonia depletes glutamate and BCCA in muscle and plasma.  A decrease in BCCA is through an up regulation of glutamine in an attempt to eliminate ammonia.
Nathan Goodyear

Acute hyperammonemia activates branched-chain amino acid catabolism... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20614225

ammonia BCCA branched chain amino acids

shared by Nathan Goodyear on 18 Nov 14 - No Cached
  • Nathan Goodyear on 18 Nov 14
     
    elevated ammonia levels reduce BCCA levels and increase glutamine levels in an attempt to eliminate ammonia.
Nathan Goodyear

The effect of long-term supplementation with branched-chain amino acid granules in pati... - 0 views

www.ncbi.nlm.nih.gov/...23090049

BCAA amino acids HCV hepatitis hepatitis C liver disease cancer hepatocellular

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    BCAA improve overall survival in HCV related liver cancer.
Nathan Goodyear

Clinical significance of therapy using branched-chain amino acid granules in patients w... - 0 views

onlinelibrary.wiley.com/...full

hepatitis C hepatitis BCAA amino acids liver disease cancer hepatocellular

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    BCAA reduces incidence of hepatocellular cancer in patients with HCV.
Nathan Goodyear

Oral supplementation with branched-chain amino acid granules prevents hepatocarcinogene... - 0 views

www.ncbi.nlm.nih.gov/...23607436

BCAA amino acids liver disease cancer HCV hepatitis C hepatocellular cirrhosis hepatitis

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    Study finds 12 g/day BCAA reduced the incidence of hepatocellular carcinoma in those patients with HCV.
Nathan Goodyear

Nutritional Modulation of Insulin Resistance - 0 views

www.hindawi.com/...424780

macronutrient macronutrients nutrition insulin resistance glucose protein carbohydrates metabolism fats

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Five branched chain and aromatic amino acids (isoleucine, leucine, valine, tyrosine, and phenylalanine) showed significant associations with future diabetes
  • there is increasing evidence that longer term high-protein intake may have detrimental effects on insulin resistance [68, 117–123], diabetes risk [69], and the risk of developing cardiovascular disease
  • high-protein and the high GI diets significantly increased markers of low-grade inflammation
  • ...5 more annotations...
  • significant and clinically relevant worsening of insulin sensitivity with an isoenergetic plant-based high-protein diet
  • healthy humans that are exposed to amino acid infusions rapidly develop insulin resistance
  • longer term high-protein intake has been shown to result in whole-body insulin resistance [68, 118], associated with upregulation of factors involved in the mammalian target of rapamycin (mTOR)/S6K1 signalling pathway [68], increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover [118] and stimulation of gluconeogenesis [68, 118].
  • it was recently shown in a large prospective cohort with 10 years followup that consuming 5% of energy from both animal and total protein at the expense of carbohydrates or fat increases diabetes risk by as much as 30% [69]. This reinforces the theory that high-protein diets can have adverse effects on glucose metabolism.
  • Another recent study showed that low-carbohydrate high-protein diets, used on a regular basis and without consideration of the nature of carbohydrates or the source of proteins, are also associated with increased risk of cardiovascular disease [70], thereby indicating a potential link between high-protein Western diets, T2DM, and cardiovascular risk.
  • Nathan Goodyear on 21 Oct 13
     
    macronutrient intake and effect on glucose regulation and thus metabolism.
Nathan Goodyear

[Protein catabolism and malnutrition in liver cirrhosis - impact of oral nutritional th... - 0 views

www.ncbi.nlm.nih.gov/...20607635

BCAA branched chain amino acids liver cirrhosis amino acids

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    Patients with liver cirrhosis will have low BCAA and thus supplementation proves to improve survival and QOL measures.
Nathan Goodyear

Probiotics for patients with hepatic encephalopathy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22071855

cochrane BCAA branched chain amino acids hepatic encephalopathy liver cirrhosis ammonia

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • Nathan Goodyear on 05 Oct 15
     
    cochrane review finds equivical evidence for probiotics in hepatic encephalopathy despite improved ammonia metabolism.
Nathan Goodyear

Leucine-enriched essential amino acid supplementation during moderate steady state exer... - 0 views

www.ajcn.org/...809.abstract

Leucine BCAA branch chain amino acids muscle athlete athletics post exercise protein synthesis

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    leucine shown to increase muscle protein synthesis post exercise
Nathan Goodyear

Frontiers | Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein ... - 1 views

journal.frontiersin.org/...full

BCAA amino acids resistance training exercise recovery exercise muscle

shared by Nathan Goodyear on 18 Jul 17 - No Cached
  • BCAAs exhibit the capacity to stimulate myofibrillar-MPS, however a full complement of EAA could be necessary to stimulate a maximal response of myofibrillar-MPS following resistance exercise
  • This information potentially has important nutritional implications for selecting amino acid supplements to facilitate skeletal muscle hypertrophy in response to resistance exercise training and the maintenance of muscle mass during aging, unloading, or disease
  • results from the present study suggest that ingesting BCAAs alone, without the other EAA, provides limited substrate for protein synthesis in exercised muscles
  • ...3 more annotations...
  • the overall response of MPS is not maximized. Instead, the limited availability of EAA likely explains the qualitative difference in magnitude of the MPS response to ingestion of BCAAs alone and ingestion of similar amounts of BCAAs as part of intact whey protein
  • decreased EAA concentrations following leucine ingestion
  • these data support the notion that EAA availability is the rate-limiting factor for stimulating a maximal MPS response to resistance exercise with BCAA ingestion
  • Nathan Goodyear on 18 Jul 17
     
    Complete amino acid supplementation exceeds muscle building capacity (myofibrillar-MPS) over BCAA alone.
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