Skip to main content

Home/ Dr. Goodyear/ Group items tagged awakening

Rss Feed Group items tagged

Nathan Goodyear

Daily life stress and the cortisol awakening respon... [PLoS One. 2012] - PubMed - NCBI - 0 views

  •  
    Interesting: cortisol levels upon awakening associated with successful stress coping during the day. 
wheelchairindia9

Wrist and Forearm Splints Causes and Recovery Period | Health | Article Point - 0 views

  •  
    Wrist and forearm splints may be suggested for people with weak wrists or for those that have been previously injured, for tendonitis wrist support and even as a preventative for those who awaken in the morning with pain or numbness after sleeping on their hands at night. The best orthopedic wrist braces for carpal tunnel syndrome, occupational stabilization and relief from the pain of wrist strains and sprains. This Right hand wrist and forearm splint from tynor is meant to be used among patients suffering from any injury or sprain in these regions. The splint is meant to provide controlled compression in various orthopaedic conditions. The splint immobilizes the area that helps in a speedier recovery. It has anatomical thumb opening that allows free movement of the thumb. It provides a lot of comfort and is easily breathable. Forearm splint is the term used to describe the forearm pain similarly the pain of lower leg over the shin is known as shin splints. Forearm splint describes the painful disease of elbow or wrist joint. Continuous pain in forearm is often caused by tendonitis, joint injury or hairline fracture of forearm bones (proximal radius or ulna near elbow joint). Overstretching of the elbow joint often causes forearm injury. Symptoms consist of a dull pain in the forearm. Pain is minor initially but increases as activity continues. Often pin-pointed to the dorsal or back of the hand side of the forearm, mid-way between the wrist and elbow. The patient may experience weakness in the wrist extensor muscles and tenderness deep in the forearm. Pain may be reproduced by attempting to bend the wrist backwards against resistance. They provided wrist splints are used in different medical institutions and hospitals for management of hand fractures. Our offered wrist splints are manufactured by skilled professionals using optimum quality basic material and advanced technology as per the set norms of market. As well, these wrist splints can be availed in v
wheelchairindia9

Tynor Wrist and Forearm Splint Right-Left - 0 views

  •  
    Tynor Wrist and Forearm Splint Right-Left Wrist and Forearm Splint is designed to immobilize and provide firm and comfortable support to hand and wrist in various orthopedic conditions. It maintains the wrist in the functional position. Aesthetically appealing. Customizable splint. Perfect immobilization. Controlled compression. Anatomical thumb opening. Tynor Wrist and Forearm Splint Right-Left Features Made out of PUF fused Matty fabric Breathable Excellent aesthetics Improved comfort Enhanced life. Removable, Aluminum Splints Customized fitting Required degree of dorsi-flexion can be achieved Very good grip and immobilization Design features Long length of the brace, ensures enhanced immobilization Brace abuts the Palmer crease , allows free finger movement. Elegant tabs , allow easy application and removal Elegant tabs, also enhance the aesthetics of the product. Black Color, enhances the aethetics Hook loop closures Easy to apply and remove Ensures optimal compression , Built in opening for thumb abduction Better pain relief and healing. Thumb remains relaxed, no fatigue Improves comfort Tynor Wrist and Forearm Splint Right-Left Measurements Measure the Circumference at a distance 6" from the wrist along the arm
Nathan Goodyear

Salivary cortisol response to awakening in chronic fatigue syndrome - 0 views

  •  
    This study found suppressed am salivary cortisol in those with CFS.
Nathan Goodyear

Decreased cortisol awakening respon... [Psychoneuroendocrinology. 2005] - PubMed - NCBI - 0 views

  •  
    early life stressors shown to reduce morning cortisol on salivary testing.  This indicates an altered HPA axis.
Nathan Goodyear

Salivary cortisol response to awakening in chronic fatigue syndrome - 0 views

  •  
    Low morning cortisol found in those with chronic fatigue syndrome.
Nathan Goodyear

A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus - 0 views

  •  
    Individuals with type II DM, found to have blunted morning cortisol and decreased hippocampal volume.  The hippocampus is the focus of memory.  This is similar to what is found in PTSD.
Nathan Goodyear

Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations ... - 0 views

  •  
    Elevated morning cortisol associated with depression in men. This study looked at saliva for assessment of free cortisol.
Nathan Goodyear

ScienceDirect - Biological Psychology : Day-to-day variation in saliva cortisol-Relatio... - 0 views

  • High evening levels of cortisol were associated with symptoms of stress and poor self-rated health
  • low cortisol levels in the morning were associated with sleepiness at awakening and anxiety, exhaustion, and poor health the day before
  •  
    lack of sleep increases cortisol in the afternoon/evening of the following day
Nathan Goodyear

Cortisol awakening response and nighttime salivary... [Yonsei Med J. 2011] - PubMed result - 0 views

  •  
    salivary cortisol useful in evaluating hypothalamus-pituitary-adrenal axis system
Nathan Goodyear

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond - PMC - 0 views

  • Pneumonia is a typical symptom of COVID-19 infection, while acute respiratory distress syndrome (ARDS) and multiple organ failure are common in severe COVID-19 patients
  • NETs are important for preventing pathogen invasion, their excessive formation can result in a slew of negative consequences, such as autoimmune inflammation and tissue damage
  • SARS-CoV-2 infection has also been linked to increased neutrophil-to-lymphocyte ratios, which is associated with disease severity and clinical prognosis
  • ...40 more annotations...
  • NETosis is a special form of programmed cell death in neutrophils, which is characterized by the extrusion of DNA, histones, and antimicrobial proteins in a web-like structure known as neutrophil extracellular traps (NETs)
    • Nathan Goodyear
       
      Definition
  • increased generation of reactive oxygen species (ROS) is a crucial intracellular process that causes NETosis
  • Another indirect route of SARS-CoV-2-induced NET production is platelet activation
  • When NETs are activated in the circulation, they can also induce hypercoagulability and thrombosis
  • In COVID-19, major NET protein cargos of NETs (i.e., NE, MPO, and histones) are significantly elevated.
  • SARS-CoV-2 can also infect host cells through noncanonical receptors such as C-type lectin receptors
  • Immunopathological manifestations, including cytokine storms and impaired adaptive immunity, are the primary drivers behind COVID-19, with neutrophil infiltration being suggested as a significant cause
  • NETosis and NETs are increasingly recognized as causes of vascular injury
  • SARS-CoV-2 and its components (e.g., spike proteins and viral RNA) attach to platelets and increase their activation and aggregation in COVID-19, resulting in vascular injury and thrombosis, both of which are linked to NET formation
    • Nathan Goodyear
       
      Connects SARS-CoV-2 to TLR on Platelets to NETosis to metastasis.
  • NET formation may be caused by activated platelets rather than SARS-CoV-2 itself
  • NETosis, leading to aberrant immunity such as cytokine storms, autoimmune disorders, and immunosuppression.
  • early bacterial coinfections were more prevalent in COVID-19 patients than those infected with other viruses
  • NETosis and NETs may also have a role in the development of post COVID-19 syndromes, including lung fibrosis, neurological disorders, tumor growth, and worsening of concomitant disease
    • Nathan Goodyear
       
      NETosis-> tumor growth
  • NETs and other by-products of NETosis have been shown to act as direct inflammation amplifiers. Hyperinflammation
  • “cytokine storm”
  • SARS-CoV-2 drives NETosis and NET formation to allow for the release of free DNA and by-products (e.g., elastases and histones). This may trigger surrounding macrophages and endothelial cells to secrete excessive proinflammatory cytokines and chemokines, which, in turn, enhance NET formation and form a positive feedback of cytokine storms in COVID-19
    • Nathan Goodyear
       
      Cycle of hyperinflammation
  • NET release enables self-antigen exposure and autoantibody production, thereby increasing the autoinflammatory response
  • patients with COVID-19 who have higher anti-NET antibodies are more likely to be detected with positive autoantibodies [e.g., antinuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA)]
  • COVID-19 NETs may act as potential inducers for autoimmune responses
  • have weakened adaptive immunity as well as a high level of inflammation
    • Nathan Goodyear
       
      Immunomodulation
  • tumor-associated NETosis and NETs promote an immunosuppressive environment in which anti-tumor immunity is compromised
  • NETs have also been shown to enhance macrophage pyroptosis in sepsis
  • facilitating an immunosuppressive microenvironment
  • persistent immunosuppression may result in bacterial co-infection or secondary infection
  • can enhance this process by interacting with neutrophils through toll-like receptor 4 (TLR4), platelet factor 4 (PF4), and extracellular vesicle-dependent processes
  • NET-induced immunosuppression in COVID-19 in the context of co-existing bacterial infection
  • Following initial onset of COVID-19, an estimated 50% or more of COVID-19 survivors may develop multi-organ problems (e.g., pulmonary dysfunction and neurologic impairment) or have worsening concomitant chronic illness
  • NETs in the bronchoalveolar lavage fluid of severe COVID-19 patients cause EMT in lung epithelial cells
  • decreased E-cadherin (an epithelial marker) expression
    • Nathan Goodyear
       
      Leads to emt
  • COVID-19 also has a long-term influence on tumor progression
  • Patients with tumors have been shown to be more vulnerable to SARS-CoV-2 infection and subsequent development of severe COVID-19
  • patients who have recovered from COVID-19 may have an increased risk of developing cancer or of cancer progression and metastasis
  • awaken cancer cells
  • NETs have been shown to change the tumor microenvironment
  • enhance tumor progression and metastasis
  • vitamin C has been tested in phase 2 clinical trials aimed at reducing COVID-19-associated mortality by reducing excessive activation of the inflammatory response
  • vitamin C is an antioxidant that significantly attenuates PMA-induced NETosis in healthy neutrophils by scavenging ROS
  • vitamin C may also inhibit NETosis and NET production in COVID-19
  • Metformin
  • Vitamin C
  •  
    NETosis intimately involved in progressive COVID, long COVID, autoimmunity, and cancer
1 - 14 of 14
Showing 20 items per page