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Nathan Goodyear

Nutrition Journal | Full text | Diverse effects of a low dose supplement of lipidated c... - 0 views

www.nutritionj.com/...79

curcumin tumeric

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    liposomal curcumin reduces Triglycerides and serum beta-amyloid protein.
Nathan Goodyear

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged p... - 0 views

www.ncbi.nlm.nih.gov/...PMC3518252

curcumin tumeric

shared by Nathan Goodyear on 03 Dec 13 - No Cached
  • Nathan Goodyear on 03 Dec 13
     
    Curcumin found to provide benefit even in the healthy. This study, though small and very short, found improvement in Triglycerides, salivary amylase, reduced oxidative stress, reduced beta-amyloid protein, increased NO, and reduced liver enzymes.
Nathan Goodyear

NeuroSignals 2005, Vol. 14, No. 1-2 - Neuroprotective Effects of Huperzine A - FullText... - 0 views

www.karger.com/...85387

Huperzine-A Huperzine brain cognition oxidative stress Alzheimer's cognitive decline NMDA

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Huperzine A is a great neuroprotector.  Huperzine A is a acetycholinesterase inhibitor. But, Huperzine A also reduces oxidative stress, reduces beta-Amyloid, protects mitochondria, antagonizes NMDA receptors and thus reduces excitotoxicity, and regulates apoptosis.
Nathan Goodyear

JAD - Volume 17, Number 3 - 0 views

www.j-alz.com/...vol17-3.html

Alzheimer's disease chelation cinnamon coffee caffeine

shared by Nathan Goodyear on 23 Feb 11 - Cached
  • Challenges Associated with Metal Chelation Therapy in Alzheimer’s Disease
  • Cinnamon Extract Inhibits Tau Aggregation Associated with Alzheimer’s Disease In Vitro
  • Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice
  • ...1 more annotation...
  • Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer’s Disease Transgenic Mice
  • Nathan Goodyear on 23 Feb 11
     
    4 abstracts highlighting coffee, cinnamon, and chelation in Alzheimer's prevention and treatment
Nathan Goodyear

SpringerLink - Neurotoxicity Research, Volume 15, Number 1 - 0 views

www.springerlink.com/...c8v25k2418440257

neurotoxicity Parkinson's disease Grape seed extract curcumin

shared by Nathan Goodyear on 13 May 11 - No Cached
  • myloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively
  • Curcumin also significantly reduced brain Aβ burden and microglia activation
  • polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD.
  • Nathan Goodyear on 13 May 11
     
    Grape seed extract and curcumin shown to reduce amyloid plaques and reduce inflammation in the brain: promising treatment in Alzheimers disease
Nathan Goodyear

Resolution of inflammation is altered in Alzheimer's disease - 0 views

www.alzheimersanddementia.com/...abstract

inflammation alzheimer disease omega 3 omega-3 n-3

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Inflammation plays an important role in Alzheimers disease.  Likewise, the ability to resolve inflammation is altered, as this study shows.  This points to natural therapies i.e. omega-3, curcumin, vitamin D...
Nathan Goodyear

Taurine prevents the neurotoxicity of beta-amyloid... [FASEB J. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15003996

Taurine melatonin Parkinson's disease excitotoxicity neurodegenerative

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    Taurine, an amino acid, and melatonin, a hormone, both aid in decreasing excitotoxicity in Parkinson's disease
Nathan Goodyear

Mitoenergetic failure in Alzheimer disease - 0 views

ajpcell.physiology.org/...C8.abstract

neuro-toxicity Alzheimer's disease mitochondria

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid toxicity in the exacerbation of AD.
  • Nathan Goodyear on 03 Mar 11
     
    discussion on mitochondria, neuro-excitotoxicity, and Alzheimer's Disease
Nathan Goodyear

Coenzyme Q10 Decreases Amyloid Pathology an... [J Alzheimers Dis. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21799249

CoQ10 excitotoxicity neurodegenerative disease Parkinson's MS Alzheimer's mitochondria

shared by Nathan Goodyear on 29 Sep 11 - No Cached
  • Nathan Goodyear on 29 Sep 11
     
    CoQ10 shown to benefit excitotoxic diseases such as Alzheimer's disease, Parkinson's, MS...
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

www.mdpi.com/...htm

vitamin C health cognition

shared by Nathan Goodyear on 28 Feb 18 - No Cached
  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
  • ...17 more annotations...
  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • adequate plasma levels (i.e., >50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
  • hypovitaminosis C (i.e., <23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
  • Nathan Goodyear on 28 Feb 18
     
    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
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